#include <Winslow99.h>
Inheritance diagram for Nektar::Winslow99:
Public Member Functions | |
| Winslow99 (const LibUtilities::SessionReaderSharedPtr &pSession, const MultiRegions::ExpListSharedPtr &pField) | |
| Constructor. More... | |
| ~Winslow99 () override | |
| Destructor. More... | |
 Public Member Functions inherited from Nektar::CellModel | |
| CellModel (const LibUtilities::SessionReaderSharedPtr &pSession, const MultiRegions::ExpListSharedPtr &pField) | |
| virtual | ~CellModel () |
| void | Initialise () |
| Initialise the cell model storage and set initial conditions. More... | |
| void | TimeIntegrate (const Array< OneD, const Array< OneD, NekDouble > > &inarray, Array< OneD, Array< OneD, NekDouble > > &outarray, const NekDouble time) |
| Time integrate the cell model by one PDE timestep. More... | |
| void | Update (const Array< OneD, const Array< OneD, NekDouble > > &inarray, Array< OneD, Array< OneD, NekDouble > > &outarray, const NekDouble time) |
| Compute the derivatives of cell model variables. More... | |
| void | GenerateSummary (SummaryList &s) |
| Print a summary of the cell model. More... | |
| size_t | GetNumCellVariables () |
| std::string | GetCellVarName (size_t idx) |
| Array< OneD, NekDouble > | GetCellSolutionCoeffs (size_t idx) |
| Array< OneD, NekDouble > | GetCellSolution (size_t idx) |
Static Public Member Functions | |
| static CellModelSharedPtr | create (const LibUtilities::SessionReaderSharedPtr &pSession, const MultiRegions::ExpListSharedPtr &pField) |
| Creates an instance of this class. More... | |
Static Public Attributes | |
| static std::string | className |
| Name of class. More... | |
Protected Member Functions | |
| void | v_Update (const Array< OneD, const Array< OneD, NekDouble > > &inarray, Array< OneD, Array< OneD, NekDouble > > &outarray, const NekDouble time) override |
| Computes the reaction terms $f(u,v)$ and $g(u,v)$. More... | |
| void | v_GenerateSummary (SummaryList &s) override |
| Prints a summary of the model parameters. More... | |
| void | v_SetInitialConditions () override |
| Set initial conditions for cell model. More... | |
| Protected Member Functions inherited from Nektar::CellModel | |
| virtual void | v_Update (const Array< OneD, const Array< OneD, NekDouble > > &inarray, Array< OneD, Array< OneD, NekDouble > > &outarray, const NekDouble time)=0 |
| virtual void | v_GenerateSummary (SummaryList &s)=0 |
| virtual std::string | v_GetCellVarName (size_t idx) |
| virtual void | v_SetInitialConditions ()=0 |
| void | LoadCellModel () |
Additional Inherited Members | |
| Protected Attributes inherited from Nektar::CellModel | |
| LibUtilities::SessionReaderSharedPtr | m_session |
| Session. More... | |
| MultiRegions::ExpListSharedPtr | m_field |
| Transmembrane potential field from PDE system. More... | |
| size_t | m_nq |
| Number of physical points. More... | |
| size_t | m_nvar |
| Number of variables in cell model (inc. transmembrane voltage) More... | |
| NekDouble | m_lastTime |
| Timestep for pde model. More... | |
| size_t | m_substeps |
| Number of substeps to take. More... | |
| Array< OneD, Array< OneD, NekDouble > > | m_cellSol |
| Cell model solution variables. More... | |
| Array< OneD, Array< OneD, NekDouble > > | m_wsp |
| Cell model integration workspace. More... | |
| bool | m_useNodal |
| Flag indicating whether nodal projection in use. More... | |
| StdRegions::StdNodalTriExpSharedPtr | m_nodalTri |
| StdNodalTri for cell model calculations. More... | |
| StdRegions::StdNodalTetExpSharedPtr | m_nodalTet |
| Array< OneD, Array< OneD, NekDouble > > | m_nodalTmp |
| Temporary array for nodal projection. More... | |
| std::vector< int > | m_concentrations |
| Indices of cell model variables which are concentrations. More... | |
| std::vector< int > | m_gates |
| Indices of cell model variables which are gates. More... | |
| Array< OneD, Array< OneD, NekDouble > > | m_gates_tau |
| Storage for gate tau values. More... | |
Detailed Description
Definition at line 42 of file Winslow99.h.
Constructor & Destructor Documentation
◆ Winslow99()
| Nektar::Winslow99::Winslow99 | ( | const LibUtilities::SessionReaderSharedPtr & | pSession, |
| const MultiRegions::ExpListSharedPtr & | pField | ||
| ) |
Constructor.
Definition at line 49 of file Winslow99.cpp.
51 : CellModel(pSession, pField)
52{
53 m_nvar = 33;
54 m_gates.push_back(1);
55 m_gates.push_back(2);
56 m_gates.push_back(3);
57 m_gates.push_back(4);
58 m_gates.push_back(5);
59 m_gates.push_back(6);
60 m_gates.push_back(7);
61 m_concentrations.push_back(8);
62 m_concentrations.push_back(9);
63 m_concentrations.push_back(10);
64 m_concentrations.push_back(11);
65 m_concentrations.push_back(12);
66 m_concentrations.push_back(13);
67 m_concentrations.push_back(14);
68 m_concentrations.push_back(15);
69 m_concentrations.push_back(16);
70 m_concentrations.push_back(17);
71 m_concentrations.push_back(18);
72 m_concentrations.push_back(19);
73 m_gates.push_back(20);
74 m_concentrations.push_back(21);
75 m_concentrations.push_back(22);
76 m_concentrations.push_back(23);
77 m_concentrations.push_back(24);
78 m_concentrations.push_back(25);
79 m_concentrations.push_back(26);
80 m_concentrations.push_back(27);
81 m_concentrations.push_back(28);
82 m_concentrations.push_back(29);
83 m_concentrations.push_back(30);
84 m_concentrations.push_back(31);
85 m_concentrations.push_back(32);
86}
std::vector< int > m_concentrations
Indices of cell model variables which are concentrations.
Definition: CellModel.h:139
std::vector< int > m_gates
Indices of cell model variables which are gates.
Definition: CellModel.h:141
size_t m_nvar
Number of variables in cell model (inc. transmembrane voltage)
Definition: CellModel.h:119
CellModel(const LibUtilities::SessionReaderSharedPtr &pSession, const MultiRegions::ExpListSharedPtr &pField)
Definition: CellModel.cpp:66
References Nektar::CellModel::m_concentrations, Nektar::CellModel::m_gates, and Nektar::CellModel::m_nvar.
◆ ~Winslow99()
|
inlineoverride |
Member Function Documentation
◆ create()
|
inlinestatic |
Creates an instance of this class.
Definition at line 47 of file Winslow99.h.
50 {
52 }
static std::shared_ptr< DataType > AllocateSharedPtr(const Args &...args)
Allocate a shared pointer from the memory pool.
Definition: NekMemoryManager.hpp:166
References Nektar::MemoryManager< DataType >::AllocateSharedPtr().
◆ v_GenerateSummary()
|
overrideprotectedvirtual |
Prints a summary of the model parameters.
Implements Nektar::CellModel.
Definition at line 1669 of file Winslow99.cpp.
1670{
1672}
void AddSummaryItem(SummaryList &l, const std::string &name, const std::string &value)
Adds a summary item to the summary info list.
Definition: Misc.cpp:47
References Nektar::SolverUtils::AddSummaryItem().
◆ v_SetInitialConditions()
|
overrideprotectedvirtual |
Set initial conditions for cell model.
Implements Nektar::CellModel.
Definition at line 1677 of file Winslow99.cpp.
1678{
1712}
Array< OneD, Array< OneD, NekDouble > > m_cellSol
Cell model solution variables.
Definition: CellModel.h:126
void Fill(int n, const T alpha, T *x, const int incx)
Fill a vector with a constant value.
Definition: Vmath.hpp:54
References Vmath::Fill(), Nektar::CellModel::m_cellSol, and Nektar::CellModel::m_nq.
◆ v_Update()
|
overrideprotectedvirtual |
Computes the reaction terms $f(u,v)$ and $g(u,v)$.
Implements Nektar::CellModel.
Definition at line 88 of file Winslow99.cpp.
92{
94 {
95
96 // Inputs:
97 // Time units: millisecond
98 NekDouble var_chaste_interface__membrane__V = inarray[0][i];
99 // Units: millivolt; Initial value: -96.1638
100 NekDouble var_chaste_interface__fast_sodium_current_m_gate__m =
101 inarray[1][i];
102 // Units: dimensionless; Initial value: 0.0328302
103 NekDouble var_chaste_interface__fast_sodium_current_h_gate__h =
104 inarray[2][i];
105 // Units: dimensionless; Initial value: 0.988354
106 NekDouble var_chaste_interface__fast_sodium_current_j_gate__j =
107 inarray[3][i];
108 // Units: dimensionless; Initial value: 0.99254
109 NekDouble
110 var_chaste_interface__rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__X_kr =
111 inarray[4][i];
112 // Units: dimensionless; Initial value: 0.51
113 NekDouble
114 var_chaste_interface__slow_activating_delayed_rectifiyer_K_current_X_ks_gate__X_ks =
115 inarray[5][i];
116 // Units: dimensionless; Initial value: 0.264
117 NekDouble
118 var_chaste_interface__transient_outward_potassium_current_X_to1_gate__X_to1 =
119 inarray[6][i];
120 // Units: dimensionless; Initial value: 2.63
121 NekDouble
122 var_chaste_interface__transient_outward_potassium_current_Y_to1_gate__Y_to1 =
123 inarray[7][i];
124 // Units: dimensionless; Initial value: 0.99
125 NekDouble var_chaste_interface__L_type_Ca_current__O = inarray[8][i];
126 // Units: dimensionless; Initial value: 9.84546e-21
127 NekDouble var_chaste_interface__L_type_Ca_current__O_Ca = inarray[9][i];
128 // Units: dimensionless; Initial value: 0
129 NekDouble var_chaste_interface__L_type_Ca_current__C0 = inarray[10][i];
130 // Units: dimensionless; Initial value: 0.997208
131 NekDouble var_chaste_interface__L_type_Ca_current__C1 = inarray[11][i];
132 // Units: dimensionless; Initial value: 6.38897e-5
133 NekDouble var_chaste_interface__L_type_Ca_current__C2 = inarray[12][i];
134 // Units: dimensionless; Initial value: 1.535e-9
135 NekDouble var_chaste_interface__L_type_Ca_current__C3 = inarray[13][i];
136 // Units: dimensionless; Initial value: 1.63909e-14
137 NekDouble var_chaste_interface__L_type_Ca_current__C4 = inarray[14][i];
138 // Units: dimensionless; Initial value: 6.56337e-20
139 NekDouble var_chaste_interface__L_type_Ca_current__C_Ca0 =
140 inarray[15][i];
141 // Units: dimensionless; Initial value: 0.00272826
142 NekDouble var_chaste_interface__L_type_Ca_current__C_Ca1 =
143 inarray[16][i];
144 // Units: dimensionless; Initial value: 6.99215e-7
145 NekDouble var_chaste_interface__L_type_Ca_current__C_Ca2 =
146 inarray[17][i];
147 // Units: dimensionless; Initial value: 6.71989e-11
148 NekDouble var_chaste_interface__L_type_Ca_current__C_Ca3 =
149 inarray[18][i];
150 // Units: dimensionless; Initial value: 2.87031e-15
151 NekDouble var_chaste_interface__L_type_Ca_current__C_Ca4 =
152 inarray[19][i];
153 // Units: dimensionless; Initial value: 4.59752e-20
154 NekDouble var_chaste_interface__L_type_Ca_current_y_gate__y =
155 inarray[20][i];
156 // Units: dimensionless; Initial value: 0.798
157 NekDouble var_chaste_interface__RyR_channel__P_O1 = inarray[21][i];
158 // Units: dimensionless; Initial value: 0
159 NekDouble var_chaste_interface__RyR_channel__P_O2 = inarray[22][i];
160 // Units: dimensionless; Initial value: 0
161 NekDouble var_chaste_interface__RyR_channel__P_C1 = inarray[23][i];
162 // Units: dimensionless; Initial value: 0.47
163 NekDouble var_chaste_interface__RyR_channel__P_C2 = inarray[24][i];
164 // Units: dimensionless; Initial value: 0.53
165 NekDouble var_chaste_interface__intracellular_Ca_fluxes__HTRPNCa =
166 inarray[25][i];
167 // Units: millimolar; Initial value: 0.98
168 NekDouble var_chaste_interface__intracellular_Ca_fluxes__LTRPNCa =
169 inarray[26][i];
170 // Units: millimolar; Initial value: 0.078
171 NekDouble var_chaste_interface__intracellular_ion_concentrations__Nai =
172 inarray[27][i];
173 // Units: millimolar; Initial value: 10
174 NekDouble var_chaste_interface__intracellular_ion_concentrations__Cai =
175 inarray[28][i];
176 // Units: millimolar; Initial value: 0.00008
177 NekDouble var_chaste_interface__intracellular_ion_concentrations__Ki =
178 inarray[29][i];
179 // Units: millimolar; Initial value: 157.8
180 NekDouble
181 var_chaste_interface__intracellular_ion_concentrations__Ca_ss =
182 inarray[30][i];
183 // Units: millimolar; Initial value: 0.00011
184 NekDouble
185 var_chaste_interface__intracellular_ion_concentrations__Ca_JSR =
186 inarray[31][i];
187 // Units: millimolar; Initial value: 0.257
188 NekDouble
189 var_chaste_interface__intracellular_ion_concentrations__Ca_NSR =
190 inarray[32][i];
191 // Units: millimolar; Initial value: 0.257
192
193 // Mathematics
194 NekDouble d_dt_chaste_interface__membrane__V;
199 var_chaste_interface__fast_sodium_current_j_gate__j; // dimensionless
201 var_chaste_interface__fast_sodium_current_h_gate__h; // dimensionless
203 12.8; // milliS_per_microF
205 var_chaste_interface__fast_sodium_current_m_gate__m; // dimensionless
207 var_chaste_interface__membrane__V; // millivolt
209 var_membrane__R; // joule_per_mole_kelvin
211 var_membrane__F; // coulomb_per_millimole
213 138.0; // millimolar
215 var_standard_ionic_concentrations__Nao; // millimolar
217 var_chaste_interface__intracellular_ion_concentrations__Nai; // millimolar
220 ((var_fast_sodium_current__R * var_fast_sodium_current__T) /
221 var_fast_sodium_current__F) *
222 log(var_fast_sodium_current__Nao /
223 var_fast_sodium_current__Nai); // millivolt
225 var_fast_sodium_current__g_Na *
226 pow(var_fast_sodium_current__m, 3.0) * var_fast_sodium_current__h *
227 var_fast_sodium_current__j *
228 (var_fast_sodium_current__V -
229 var_fast_sodium_current__E_Na); // microA_per_microF
231 var_chaste_interface__L_type_Ca_current__O; // dimensionless
233 var_membrane__F; // coulomb_per_millimole
235 0.0003125; // cm_per_second
237 2.0; // millimolar
239 var_standard_ionic_concentrations__Cao; // millimolar
241 var_chaste_interface__membrane__V; // millivolt
244 var_membrane__R; // joule_per_mole_kelvin
246 ((((var_L_type_Ca_current__P_Ca / (1.0 * 1.0)) * 4.0 *
247 var_L_type_Ca_current__V * pow(var_L_type_Ca_current__F, 2.0) *
248 1000.0) /
249 (var_L_type_Ca_current__R * var_L_type_Ca_current__T)) *
250 ((0.001 *
251 exp((2.0 * var_L_type_Ca_current__V * var_L_type_Ca_current__F) /
252 (var_L_type_Ca_current__R * var_L_type_Ca_current__T))) -
253 (0.341 * var_L_type_Ca_current__Cao))) /
254 (exp((2.0 * var_L_type_Ca_current__V * var_L_type_Ca_current__F) /
255 (var_L_type_Ca_current__R * var_L_type_Ca_current__T)) -
256 1.0); // microA_per_microF
258 var_chaste_interface__L_type_Ca_current_y_gate__y; // dimensionless
260 var_chaste_interface__L_type_Ca_current__O_Ca; // dimensionless
262 var_L_type_Ca_current__i_Ca_max * var_L_type_Ca_current__y *
263 (var_L_type_Ca_current__O +
264 var_L_type_Ca_current__O_Ca); // microA_per_microF
267 -0.265; // microA_per_microF
269 var_L_type_Ca_current__P_K /
270 (1.0 + (var_L_type_Ca_current__i_Ca_max /
271 var_L_type_Ca_current__i_Ca_half)); // cm_per_second
273 4.0; // millimolar
275 var_standard_ionic_concentrations__Ko; // millimolar
277 var_chaste_interface__intracellular_ion_concentrations__Ki; // millimolar
279 ((((var_L_type_Ca_current__p_prime_k / (1.0 * 1.0)) *
280 var_L_type_Ca_current__y *
281 (var_L_type_Ca_current__O + var_L_type_Ca_current__O_Ca) *
282 var_L_type_Ca_current__V * pow(var_L_type_Ca_current__F, 2.0)) /
283 (var_L_type_Ca_current__R * var_L_type_Ca_current__T)) *
284 ((var_L_type_Ca_current__Ki *
285 exp((var_L_type_Ca_current__V * var_L_type_Ca_current__F) /
286 (var_L_type_Ca_current__R * var_L_type_Ca_current__T))) -
287 var_L_type_Ca_current__Ko)) /
288 (exp((var_L_type_Ca_current__V * var_L_type_Ca_current__F) /
289 (var_L_type_Ca_current__R * var_L_type_Ca_current__T)) -
290 1.0); // microA_per_microF
292 var_standard_ionic_concentrations__Ko; // millimolar
294 var_rapid_activating_delayed_rectifiyer_K_current__f_Ko =
295 sqrt(var_rapid_activating_delayed_rectifiyer_K_current__Ko /
296 4.0); // dimensionless
298 var_chaste_interface__intracellular_ion_concentrations__Ki; // millimolar
300 var_membrane__R; // joule_per_mole_kelvin
302 var_membrane__F; // coulomb_per_millimole
304 var_membrane__T; // kelvin
306 ((var_rapid_activating_delayed_rectifiyer_K_current__R *
307 var_rapid_activating_delayed_rectifiyer_K_current__T) /
308 var_rapid_activating_delayed_rectifiyer_K_current__F) *
309 log(var_rapid_activating_delayed_rectifiyer_K_current__Ko /
310 var_rapid_activating_delayed_rectifiyer_K_current__Ki); // millivolt
312 var_chaste_interface__membrane__V; // millivolt
314 1.0 /
315 (1.0 +
316 (1.4945 *
317 exp(0.0446 *
318 var_rapid_activating_delayed_rectifiyer_K_current__V))); // dimensionless
320 var_chaste_interface__rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__X_kr; // dimensionless
322 var_rapid_activating_delayed_rectifiyer_K_current__g_Kr =
323 0.0034; // milliS_per_microF
325 var_rapid_activating_delayed_rectifiyer_K_current__g_Kr *
326 var_rapid_activating_delayed_rectifiyer_K_current__f_Ko *
327 var_rapid_activating_delayed_rectifiyer_K_current__R_V *
328 var_rapid_activating_delayed_rectifiyer_K_current__X_kr *
329 (var_rapid_activating_delayed_rectifiyer_K_current__V -
330 var_rapid_activating_delayed_rectifiyer_K_current__E_K); // microA_per_microF
332 0.0027134; // milliS_per_microF
334 var_standard_ionic_concentrations__Ko; // millimolar
336 var_standard_ionic_concentrations__Nao; // millimolar
338 var_chaste_interface__intracellular_ion_concentrations__Ki; // millimolar
340 var_chaste_interface__intracellular_ion_concentrations__Nai; // millimolar
342 var_membrane__R; // joule_per_mole_kelvin
344 var_membrane__F; // coulomb_per_millimole
346 var_membrane__T; // kelvin
348 ((var_slow_activating_delayed_rectifiyer_K_current__R *
349 var_slow_activating_delayed_rectifiyer_K_current__T) /
350 var_slow_activating_delayed_rectifiyer_K_current__F) *
351 log((var_slow_activating_delayed_rectifiyer_K_current__Ko +
352 (0.01833 *
353 var_slow_activating_delayed_rectifiyer_K_current__Nao)) /
354 (var_slow_activating_delayed_rectifiyer_K_current__Ki +
355 (0.01833 *
356 var_slow_activating_delayed_rectifiyer_K_current__Nai))); // millivolt
358 var_chaste_interface__membrane__V; // millivolt
360 var_chaste_interface__slow_activating_delayed_rectifiyer_K_current_X_ks_gate__X_ks; // dimensionless
362 var_slow_activating_delayed_rectifiyer_K_current__g_Ks *
363 pow(var_slow_activating_delayed_rectifiyer_K_current__X_ks, 2.0) *
364 (var_slow_activating_delayed_rectifiyer_K_current__V -
365 var_slow_activating_delayed_rectifiyer_K_current__E_Ks); // microA_per_microF
367 var_chaste_interface__transient_outward_potassium_current_X_to1_gate__X_to1; // dimensionless
369 var_chaste_interface__transient_outward_potassium_current_Y_to1_gate__Y_to1; // dimensionless
371 0.23815; // milliS_per_microF
373 var_rapid_activating_delayed_rectifiyer_K_current__E_K; // millivolt
375 var_chaste_interface__membrane__V; // millivolt
377 var_transient_outward_potassium_current__g_to1 *
378 var_transient_outward_potassium_current__X_to1 *
379 var_transient_outward_potassium_current__Y_to1 *
380 (var_transient_outward_potassium_current__V -
381 var_transient_outward_potassium_current__E_K); // microA_per_microF
383 var_standard_ionic_concentrations__Ko; // millimolar
385 var_rapid_activating_delayed_rectifiyer_K_current__E_K; // millivolt
387 var_membrane__F; // coulomb_per_millimole
389 var_time_independent_potassium_current__F; // coulomb_per_millimole
391 var_chaste_interface__membrane__V; // millivolt
393 var_time_independent_potassium_current__V; // millivolt
395 var_membrane__T; // kelvin
397 var_time_independent_potassium_current__T; // kelvin
399 var_time_independent_potassium_current__E_K; // millivolt
401 var_membrane__R; // joule_per_mole_kelvin
403 var_time_independent_potassium_current__R; // joule_per_mole_kelvin
405 var_time_independent_potassium_current_K1_gate__K1_infinity_V =
406 1.0 /
407 (2.0 +
408 exp(((1.5 *
409 var_time_independent_potassium_current_K1_gate__F) /
410 (var_time_independent_potassium_current_K1_gate__R *
411 var_time_independent_potassium_current_K1_gate__T)) *
412 (var_time_independent_potassium_current_K1_gate__V -
413 var_time_independent_potassium_current_K1_gate__E_K))); // dimensionless
415 var_time_independent_potassium_current_K1_gate__K1_infinity_V; // dimensionless
417 2.8; // milliS_per_microF
419 13.0; // millimolar
421 ((var_time_independent_potassium_current__g_K1 *
422 var_time_independent_potassium_current__K1_infinity_V *
423 var_time_independent_potassium_current__Ko) /
424 (var_time_independent_potassium_current__Ko +
425 var_time_independent_potassium_current__K_mK1)) *
426 (var_time_independent_potassium_current__V -
427 var_time_independent_potassium_current__E_K); // microA_per_microF
429 0.002216; // milliS_per_microF
431 var_chaste_interface__membrane__V; // millivolt
433 var_plateau_potassium_current__V; // millivolt
435 1.0 /
436 (1.0 + exp((7.488 - var_plateau_potassium_current_Kp_gate__V) /
437 5.98)); // dimensionless
439 var_plateau_potassium_current_Kp_gate__Kp_V; // dimensionless
441 var_rapid_activating_delayed_rectifiyer_K_current__E_K; // millivolt
443 var_plateau_potassium_current__g_Kp *
444 var_plateau_potassium_current__Kp_V *
445 (var_plateau_potassium_current__V -
446 var_plateau_potassium_current__E_K); // microA_per_microF
448 var_standard_ionic_concentrations__Nao; // millimolar
452 var_chaste_interface__intracellular_ion_concentrations__Nai; // millimolar
455 var_chaste_interface__membrane__V; // millivolt
458 var_standard_ionic_concentrations__Cao; // millimolar
462 var_membrane__F; // coulomb_per_millimole
464 var_membrane__R; // joule_per_mole_kelvin
466 var_chaste_interface__intracellular_ion_concentrations__Cai; // millimolar
468 ((var_Na_Ca_exchanger__K_NaCa * 5000.0) /
469 ((pow(var_Na_Ca_exchanger__K_mNa, 3.0) +
470 pow(var_Na_Ca_exchanger__Nao, 3.0)) *
471 (var_Na_Ca_exchanger__K_mCa + var_Na_Ca_exchanger__Cao) *
472 (1.0 +
473 (var_Na_Ca_exchanger__K_sat *
474 exp(((var_Na_Ca_exchanger__eta - 1.0) * var_Na_Ca_exchanger__V *
475 var_Na_Ca_exchanger__F) /
476 (var_Na_Ca_exchanger__R * var_Na_Ca_exchanger__T)))))) *
477 ((exp((var_Na_Ca_exchanger__eta * var_Na_Ca_exchanger__V *
478 var_Na_Ca_exchanger__F) /
479 (var_Na_Ca_exchanger__R * var_Na_Ca_exchanger__T)) *
480 pow(var_Na_Ca_exchanger__Nai, 3.0) * var_Na_Ca_exchanger__Cao) -
481 (exp(((var_Na_Ca_exchanger__eta - 1.0) * var_Na_Ca_exchanger__V *
482 var_Na_Ca_exchanger__F) /
483 (var_Na_Ca_exchanger__R * var_Na_Ca_exchanger__T)) *
484 pow(var_Na_Ca_exchanger__Nao, 3.0) *
485 var_Na_Ca_exchanger__Cai)); // microA_per_microF
487 var_standard_ionic_concentrations__Ko; // millimolar
490 var_chaste_interface__intracellular_ion_concentrations__Nai; // millimolar
492 var_chaste_interface__membrane__V; // millivolt
494 var_membrane__F; // coulomb_per_millimole
496 var_membrane__T; // kelvin
498 var_standard_ionic_concentrations__Nao; // millimolar
500 (1.0 / 7.0) *
501 (exp(var_sodium_potassium_pump__Nao / 67.3) - 1.0); // dimensionless
503 var_membrane__R; // joule_per_mole_kelvin
505 1.0 / (1.0 +
506 (0.1245 * exp(((-0.1) * var_sodium_potassium_pump__V *
507 var_sodium_potassium_pump__F) /
508 (var_sodium_potassium_pump__R *
509 var_sodium_potassium_pump__T))) +
510 (0.0365 * var_sodium_potassium_pump__sigma *
511 exp(((-var_sodium_potassium_pump__V) *
512 var_sodium_potassium_pump__F) /
513 (var_sodium_potassium_pump__R *
514 var_sodium_potassium_pump__T)))); // dimensionless
516 0.693; // microA_per_microF
519 (((var_sodium_potassium_pump__I_NaK *
520 var_sodium_potassium_pump__f_NaK) /
521 (1.0 + pow(var_sodium_potassium_pump__K_mNai /
522 var_sodium_potassium_pump__Nai,
523 1.5))) *
524 var_sodium_potassium_pump__Ko) /
525 (var_sodium_potassium_pump__Ko +
526 var_sodium_potassium_pump__K_mKo); // microA_per_microF
528 0.05; // microA_per_microF
530 var_chaste_interface__intracellular_ion_concentrations__Cai; // millimolar
532 5e-05; // millimolar
534 (var_sarcolemmal_calcium_pump__I_pCa *
535 var_sarcolemmal_calcium_pump__Cai) /
536 (var_sarcolemmal_calcium_pump__K_mpCa +
537 var_sarcolemmal_calcium_pump__Cai); // microA_per_microF
539 var_membrane__R; // joule_per_mole_kelvin
541 var_chaste_interface__intracellular_ion_concentrations__Cai; // millimolar
543 var_membrane__F; // coulomb_per_millimole
545 var_membrane__T; // kelvin
547 var_standard_ionic_concentrations__Cao; // millimolar
549 ((var_calcium_background_current__R *
550 var_calcium_background_current__T) /
551 (2.0 * var_calcium_background_current__F)) *
552 log(var_calcium_background_current__Cao /
553 var_calcium_background_current__Cai); // millivolt
555 0.0003842; // milliS_per_microF
557 var_chaste_interface__membrane__V; // millivolt
559 var_calcium_background_current__g_Cab *
560 (var_calcium_background_current__V -
561 var_calcium_background_current__E_Ca); // microA_per_microF
563 0.0031; // milliS_per_microF
565 var_chaste_interface__membrane__V; // millivolt
567 var_fast_sodium_current__E_Na; // millivolt
569 var_sodium_background_current__g_Nab *
570 (var_sodium_background_current__V -
571 var_sodium_background_current__E_Na); // microA_per_microF
573 var_fast_sodium_current__V; // millivolt
575 80.0 *
576 exp((-var_fast_sodium_current_m_gate__V) / 11.0); // per_second
578 var_fast_sodium_current_m_gate__V + 47.13; // millivolt
580 (fabs(var_fast_sodium_current_m_gate__E0_m) < 1e-05)
581 ? (1000.0 /
582 (0.1 - (0.005 * var_fast_sodium_current_m_gate__E0_m)))
583 : ((320.0 * var_fast_sodium_current_m_gate__E0_m) /
584 (1.0 -
585 exp((-0.1) *
586 var_fast_sodium_current_m_gate__E0_m))); // per_second
588 var_fast_sodium_current__m; // dimensionless
590 var_fast_sodium_current_m_gate__d_m_d_environment__time =
591 (var_fast_sodium_current_m_gate__V >= (-90.0))
592 ? ((var_fast_sodium_current_m_gate__alpha_m *
593 (1.0 - var_fast_sodium_current_m_gate__m)) -
594 (var_fast_sodium_current_m_gate__beta_m *
595 var_fast_sodium_current_m_gate__m))
596 : 0.0; // per_second
598 var_fast_sodium_current__fast_sodium_current_m_gate__d_m_d_environment__time =
599 var_fast_sodium_current_m_gate__d_m_d_environment__time; // per_second
601 var_fast_sodium_current__V; // millivolt
603 (var_fast_sodium_current_h_gate__V < (-40.0))
604 ? ((3560.0 * exp(0.079 * var_fast_sodium_current_h_gate__V)) +
605 (310000.0 * exp(0.35 * var_fast_sodium_current_h_gate__V)))
606 : (1000.0 /
607 (0.13 *
608 (1.0 + exp((var_fast_sodium_current_h_gate__V + 10.66) /
609 (-11.1))))); // per_second
611 (var_fast_sodium_current_h_gate__V < (-40.0))
612 ? (135.0 *
613 exp((80.0 + var_fast_sodium_current_h_gate__V) / (-6.8)))
614 : 0.0; // per_second
616 var_fast_sodium_current__h; // dimensionless
618 var_fast_sodium_current_h_gate__d_h_d_environment__time =
619 (var_fast_sodium_current_h_gate__alpha_h *
620 (1.0 - var_fast_sodium_current_h_gate__h)) -
621 (var_fast_sodium_current_h_gate__beta_h *
622 var_fast_sodium_current_h_gate__h); // per_second
624 var_fast_sodium_current__fast_sodium_current_h_gate__d_h_d_environment__time =
625 var_fast_sodium_current_h_gate__d_h_d_environment__time; // per_second
627 var_fast_sodium_current__V; // millivolt
629 (var_fast_sodium_current_j_gate__V < (-40.0))
630 ? ((1000.0 *
631 (-((127140.0 *
632 exp(0.2444 * var_fast_sodium_current_j_gate__V)) +
633 (3.474e-05 *
634 exp((-0.04391) * var_fast_sodium_current_j_gate__V)))) *
635 (var_fast_sodium_current_j_gate__V + 37.78)) /
636 (1.0 +
637 exp(0.311 * (var_fast_sodium_current_j_gate__V + 79.23))))
638 : 0.0; // per_second
640 (var_fast_sodium_current_j_gate__V < (-40.0))
641 ? ((121.2 *
642 exp((-0.01052) * var_fast_sodium_current_j_gate__V)) /
643 (1.0 + exp((-0.1378) *
644 (var_fast_sodium_current_j_gate__V + 40.14))))
645 : ((300.0 *
646 exp((-2.535e-07) * var_fast_sodium_current_j_gate__V)) /
647 (1.0 + exp((-0.1) * (var_fast_sodium_current_j_gate__V +
648 32.0)))); // per_second
650 var_fast_sodium_current__j; // dimensionless
652 var_fast_sodium_current_j_gate__d_j_d_environment__time =
653 (var_fast_sodium_current_j_gate__alpha_j *
654 (1.0 - var_fast_sodium_current_j_gate__j)) -
655 (var_fast_sodium_current_j_gate__beta_j *
656 var_fast_sodium_current_j_gate__j); // per_second
658 var_fast_sodium_current__fast_sodium_current_j_gate__d_j_d_environment__time =
659 var_fast_sodium_current_j_gate__d_j_d_environment__time; // per_second
661 var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__tau_factor =
662 1.0; // dimensionless
664 var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__V =
665 var_rapid_activating_delayed_rectifiyer_K_current__V; // millivolt
667 var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__K21 = exp(
668 (-7.677) -
669 (0.0128 *
670 var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__V)); // dimensionless
672 var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__K12 = exp(
673 (-5.495) +
674 (0.1691 *
675 var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__V)); // dimensionless
677 (0.001 /
678 (var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__K12 +
679 var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__K21)) +
680 (var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__tau_factor *
681 0.027); // second
683 var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__X_kr =
684 var_rapid_activating_delayed_rectifiyer_K_current__X_kr; // dimensionless
686 var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__X_kr_inf =
687 var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__K12 /
688 (var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__K12 +
689 var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__K21); // dimensionless
690 const NekDouble var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__d_X_kr_d_environment__time =
691 (var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__X_kr_inf -
692 var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__X_kr) /
693 var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__tau_X_kr; // per_second
695 var_rapid_activating_delayed_rectifiyer_K_current__rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__d_X_kr_d_environment__time =
696 var_rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__d_X_kr_d_environment__time; // per_second
698 var_slow_activating_delayed_rectifiyer_K_current_X_ks_gate__V =
699 var_slow_activating_delayed_rectifiyer_K_current__V; // millivolt
701 0.001 /
702 (((7.19e-05 *
703 (var_slow_activating_delayed_rectifiyer_K_current_X_ks_gate__V -
704 10.0)) /
705 (1.0 -
706 exp((-0.148) *
707 (var_slow_activating_delayed_rectifiyer_K_current_X_ks_gate__V -
708 10.0)))) +
709 ((0.000131 *
710 (var_slow_activating_delayed_rectifiyer_K_current_X_ks_gate__V -
711 10.0)) /
712 (exp(0.0687 *
713 (var_slow_activating_delayed_rectifiyer_K_current_X_ks_gate__V -
714 10.0)) -
715 1.0))); // second
717 var_slow_activating_delayed_rectifiyer_K_current_X_ks_gate__X_ks_infinity =
718 1.0 /
719 (1.0 +
720 exp((-(var_slow_activating_delayed_rectifiyer_K_current_X_ks_gate__V -
721 24.7)) /
722 13.6)); // dimensionless
724 var_slow_activating_delayed_rectifiyer_K_current_X_ks_gate__X_ks =
725 var_slow_activating_delayed_rectifiyer_K_current__X_ks; // dimensionless
726 const NekDouble var_slow_activating_delayed_rectifiyer_K_current_X_ks_gate__d_X_ks_d_environment__time =
727 (var_slow_activating_delayed_rectifiyer_K_current_X_ks_gate__X_ks_infinity -
728 var_slow_activating_delayed_rectifiyer_K_current_X_ks_gate__X_ks) /
729 var_slow_activating_delayed_rectifiyer_K_current_X_ks_gate__tau_X_ks; // per_second
731 var_slow_activating_delayed_rectifiyer_K_current__slow_activating_delayed_rectifiyer_K_current_X_ks_gate__d_X_ks_d_environment__time =
732 var_slow_activating_delayed_rectifiyer_K_current_X_ks_gate__d_X_ks_d_environment__time; // per_second
734 var_transient_outward_potassium_current__V; // millivolt
736 var_transient_outward_potassium_current_X_to1_gate__alpha_X_to1 =
737 45.16 *
738 exp(0.03577 *
739 var_transient_outward_potassium_current_X_to1_gate__V); // per_second
741 var_transient_outward_potassium_current_X_to1_gate__X_to1 =
742 var_transient_outward_potassium_current__X_to1; // dimensionless
744 var_transient_outward_potassium_current_X_to1_gate__beta_X_to1 =
745 98.9 *
746 exp((-0.06237) *
747 var_transient_outward_potassium_current_X_to1_gate__V); // per_second
749 var_transient_outward_potassium_current_X_to1_gate__d_X_to1_d_environment__time =
750 (var_transient_outward_potassium_current_X_to1_gate__alpha_X_to1 *
751 (1.0 -
752 var_transient_outward_potassium_current_X_to1_gate__X_to1)) -
753 (var_transient_outward_potassium_current_X_to1_gate__beta_X_to1 *
754 var_transient_outward_potassium_current_X_to1_gate__X_to1); // per_second
756 var_transient_outward_potassium_current__transient_outward_potassium_current_X_to1_gate__d_X_to1_d_environment__time =
757 var_transient_outward_potassium_current_X_to1_gate__d_X_to1_d_environment__time; // per_second
759 var_transient_outward_potassium_current__V; // millivolt
761 var_transient_outward_potassium_current_Y_to1_gate__alpha_Y_to1 =
762 (5.415 *
763 exp((-(var_transient_outward_potassium_current_Y_to1_gate__V +
764 33.5)) /
765 5.0)) /
766 (1.0 +
767 (0.051335 *
768 exp((-(var_transient_outward_potassium_current_Y_to1_gate__V +
769 33.5)) /
770 5.0))); // per_second
772 var_transient_outward_potassium_current_Y_to1_gate__Y_to1 =
773 var_transient_outward_potassium_current__Y_to1; // dimensionless
775 var_transient_outward_potassium_current_Y_to1_gate__beta_Y_to1 =
776 (5.415 *
777 exp((var_transient_outward_potassium_current_Y_to1_gate__V +
778 33.5) /
779 5.0)) /
780 (1.0 +
781 (0.051335 *
782 exp((var_transient_outward_potassium_current_Y_to1_gate__V +
783 33.5) /
784 5.0))); // per_second
786 var_transient_outward_potassium_current_Y_to1_gate__d_Y_to1_d_environment__time =
787 (var_transient_outward_potassium_current_Y_to1_gate__alpha_Y_to1 *
788 (1.0 -
789 var_transient_outward_potassium_current_Y_to1_gate__Y_to1)) -
790 (var_transient_outward_potassium_current_Y_to1_gate__beta_Y_to1 *
791 var_transient_outward_potassium_current_Y_to1_gate__Y_to1); // per_second
793 var_transient_outward_potassium_current__transient_outward_potassium_current_Y_to1_gate__d_Y_to1_d_environment__time =
794 var_transient_outward_potassium_current_Y_to1_gate__d_Y_to1_d_environment__time; // per_second
796 400.0 * exp((var_L_type_Ca_current__V + 2.0) / 10.0); // per_second
798 50.0 *
799 exp((-(var_L_type_Ca_current__V + 2.0)) / 13.0); // per_second
801 var_chaste_interface__intracellular_ion_concentrations__Ca_ss; // millimolar
803 (103.75 * var_L_type_Ca_current__Ca_ss) / 1.0; // per_second
806 var_L_type_Ca_current__alpha *
807 var_L_type_Ca_current__a; // per_second
810 var_L_type_Ca_current__beta /
811 var_L_type_Ca_current__b; // per_second
818 var_chaste_interface__L_type_Ca_current__C0; // dimensionless
820 var_chaste_interface__L_type_Ca_current__C1; // dimensionless
822 var_chaste_interface__L_type_Ca_current__C2; // dimensionless
824 var_chaste_interface__L_type_Ca_current__C3; // dimensionless
826 var_chaste_interface__L_type_Ca_current__C4; // dimensionless
828 var_chaste_interface__L_type_Ca_current__C_Ca0; // dimensionless
830 var_chaste_interface__L_type_Ca_current__C_Ca1; // dimensionless
832 var_chaste_interface__L_type_Ca_current__C_Ca2; // dimensionless
834 var_chaste_interface__L_type_Ca_current__C_Ca3; // dimensionless
836 var_chaste_interface__L_type_Ca_current__C_Ca4; // dimensionless
838 (var_L_type_Ca_current__f * var_L_type_Ca_current__C4) -
839 (var_L_type_Ca_current__g * var_L_type_Ca_current__O); // per_second
841 (var_L_type_Ca_current__fprime * var_L_type_Ca_current__C_Ca4) -
842 (var_L_type_Ca_current__gprime *
843 var_L_type_Ca_current__O_Ca); // per_second
845 ((var_L_type_Ca_current__beta * var_L_type_Ca_current__C1) +
846 (var_L_type_Ca_current__omega * var_L_type_Ca_current__C_Ca0)) -
847 (((4.0 * var_L_type_Ca_current__alpha) +
848 var_L_type_Ca_current__gamma) *
849 var_L_type_Ca_current__C0); // per_second
851 ((4.0 * var_L_type_Ca_current__alpha * var_L_type_Ca_current__C0) +
852 (2.0 * var_L_type_Ca_current__beta * var_L_type_Ca_current__C2) +
853 ((var_L_type_Ca_current__omega / var_L_type_Ca_current__b) *
854 var_L_type_Ca_current__C_Ca1)) -
855 ((var_L_type_Ca_current__beta +
856 (3.0 * var_L_type_Ca_current__alpha) +
857 (var_L_type_Ca_current__gamma * var_L_type_Ca_current__a)) *
858 var_L_type_Ca_current__C1); // per_second
860 ((3.0 * var_L_type_Ca_current__alpha * var_L_type_Ca_current__C1) +
861 (3.0 * var_L_type_Ca_current__beta * var_L_type_Ca_current__C3) +
862 ((var_L_type_Ca_current__omega /
863 pow(var_L_type_Ca_current__b, 2.0)) *
864 var_L_type_Ca_current__C_Ca2)) -
865 (((var_L_type_Ca_current__beta * 2.0) +
866 (2.0 * var_L_type_Ca_current__alpha) +
867 (var_L_type_Ca_current__gamma *
868 pow(var_L_type_Ca_current__a, 2.0))) *
869 var_L_type_Ca_current__C2); // per_second
871 ((2.0 * var_L_type_Ca_current__alpha * var_L_type_Ca_current__C2) +
872 (4.0 * var_L_type_Ca_current__beta * var_L_type_Ca_current__C4) +
873 ((var_L_type_Ca_current__omega /
874 pow(var_L_type_Ca_current__b, 3.0)) *
875 var_L_type_Ca_current__C_Ca3)) -
876 (((var_L_type_Ca_current__beta * 3.0) +
877 var_L_type_Ca_current__alpha +
878 (var_L_type_Ca_current__gamma *
879 pow(var_L_type_Ca_current__a, 3.0))) *
880 var_L_type_Ca_current__C3); // per_second
882 ((var_L_type_Ca_current__alpha * var_L_type_Ca_current__C3) +
883 (var_L_type_Ca_current__g * var_L_type_Ca_current__O) +
884 ((var_L_type_Ca_current__omega /
885 pow(var_L_type_Ca_current__b, 4.0)) *
886 var_L_type_Ca_current__C_Ca4)) -
887 (((var_L_type_Ca_current__beta * 4.0) + var_L_type_Ca_current__f +
888 (var_L_type_Ca_current__gamma *
889 pow(var_L_type_Ca_current__a, 4.0))) *
890 var_L_type_Ca_current__C4); // per_second
892 ((var_L_type_Ca_current__beta_b * var_L_type_Ca_current__C_Ca1) +
893 (var_L_type_Ca_current__gamma * var_L_type_Ca_current__C0)) -
894 (((4.0 * var_L_type_Ca_current__alpha_a) +
895 var_L_type_Ca_current__omega) *
896 var_L_type_Ca_current__C_Ca0); // per_second
898 ((4.0 * var_L_type_Ca_current__alpha_a *
899 var_L_type_Ca_current__C_Ca0) +
900 (2.0 * var_L_type_Ca_current__beta_b *
901 var_L_type_Ca_current__C_Ca2) +
902 (var_L_type_Ca_current__gamma * var_L_type_Ca_current__a *
903 var_L_type_Ca_current__C1)) -
904 ((var_L_type_Ca_current__beta_b +
905 (3.0 * var_L_type_Ca_current__alpha_a) +
906 (var_L_type_Ca_current__omega / var_L_type_Ca_current__b)) *
907 var_L_type_Ca_current__C_Ca1); // per_second
909 ((3.0 * var_L_type_Ca_current__alpha_a *
910 var_L_type_Ca_current__C_Ca1) +
911 (3.0 * var_L_type_Ca_current__beta_b *
912 var_L_type_Ca_current__C_Ca3) +
913 (var_L_type_Ca_current__gamma *
914 pow(var_L_type_Ca_current__a, 2.0) * var_L_type_Ca_current__C2)) -
915 (((var_L_type_Ca_current__beta_b * 2.0) +
916 (2.0 * var_L_type_Ca_current__alpha_a) +
917 (var_L_type_Ca_current__omega /
918 pow(var_L_type_Ca_current__b, 2.0))) *
919 var_L_type_Ca_current__C_Ca2); // per_second
921 ((2.0 * var_L_type_Ca_current__alpha_a *
922 var_L_type_Ca_current__C_Ca2) +
923 (4.0 * var_L_type_Ca_current__beta_b *
924 var_L_type_Ca_current__C_Ca4) +
925 (var_L_type_Ca_current__gamma *
926 pow(var_L_type_Ca_current__a, 3.0) * var_L_type_Ca_current__C3)) -
927 (((var_L_type_Ca_current__beta_b * 3.0) +
928 var_L_type_Ca_current__alpha_a +
929 (var_L_type_Ca_current__omega /
930 pow(var_L_type_Ca_current__b, 3.0))) *
931 var_L_type_Ca_current__C_Ca3); // per_second
933 ((var_L_type_Ca_current__alpha_a * var_L_type_Ca_current__C_Ca3) +
934 (var_L_type_Ca_current__gprime * var_L_type_Ca_current__O_Ca) +
935 (var_L_type_Ca_current__gamma *
936 pow(var_L_type_Ca_current__a, 4.0) * var_L_type_Ca_current__C4)) -
937 (((var_L_type_Ca_current__beta_b * 4.0) +
938 var_L_type_Ca_current__fprime +
939 (var_L_type_Ca_current__omega /
940 pow(var_L_type_Ca_current__b, 4.0))) *
941 var_L_type_Ca_current__C_Ca4); // per_second
943 var_L_type_Ca_current__y; // dimensionless
945 var_L_type_Ca_current__V; // millivolt
947 (0.8 /
948 (1.0 + exp((var_L_type_Ca_current_y_gate__V + 12.5) / 5.0))) +
949 0.2; // dimensionless
951 (20.0 +
952 (600.0 /
953 (1.0 + exp((var_L_type_Ca_current_y_gate__V + 20.0) / 9.5)))) /
954 1000.0; // second
956 (var_L_type_Ca_current_y_gate__y_infinity -
957 var_L_type_Ca_current_y_gate__y) /
958 var_L_type_Ca_current_y_gate__tau_y; // per_second
960 var_L_type_Ca_current__L_type_Ca_current_y_gate__d_y_d_environment__time =
961 var_L_type_Ca_current_y_gate__d_y_d_environment__time; // per_second
963 var_chaste_interface__RyR_channel__P_O2; // dimensionless
965 var_chaste_interface__intracellular_ion_concentrations__Ca_ss; // millimolar
967 var_chaste_interface__RyR_channel__P_O1; // dimensionless
970 var_chaste_interface__intracellular_ion_concentrations__Ca_JSR; // millimolar
972 var_RyR_channel__v1 *
973 (var_RyR_channel__P_O1 + var_RyR_channel__P_O2) *
974 (var_RyR_channel__Ca_JSR -
975 var_RyR_channel__Ca_ss); // millimolar_per_second
977 1.215e+13; // millimolar4_per_second
980 4050000000.0; // millimolar3_per_second
985 var_chaste_interface__RyR_channel__P_C1; // dimensionless
987 var_chaste_interface__RyR_channel__P_C2; // dimensionless
991 ((var_RyR_channel__k_a_plus *
992 pow(var_RyR_channel__Ca_ss, var_RyR_channel__n) *
993 var_RyR_channel__P_C1) -
994 ((var_RyR_channel__k_a_minus * var_RyR_channel__P_O1) +
995 (var_RyR_channel__k_b_plus *
996 pow(var_RyR_channel__Ca_ss, var_RyR_channel__m) *
997 var_RyR_channel__P_O1) +
998 (var_RyR_channel__k_c_plus * var_RyR_channel__P_O1))) +
999 (var_RyR_channel__k_b_minus * var_RyR_channel__P_O2) +
1000 (var_RyR_channel__k_c_minus * var_RyR_channel__P_C2); // per_second
1002 (var_RyR_channel__k_b_plus *
1003 pow(var_RyR_channel__Ca_ss, var_RyR_channel__m) *
1004 var_RyR_channel__P_O1) -
1005 (var_RyR_channel__k_b_minus * var_RyR_channel__P_O2); // per_second
1007 ((-var_RyR_channel__k_a_plus) *
1008 pow(var_RyR_channel__Ca_ss, var_RyR_channel__n) *
1009 var_RyR_channel__P_C1) +
1010 (var_RyR_channel__k_a_minus * var_RyR_channel__P_O1); // per_second
1012 (var_RyR_channel__k_c_plus * var_RyR_channel__P_O1) -
1013 (var_RyR_channel__k_c_minus * var_RyR_channel__P_C2); // per_second
1015 var_chaste_interface__intracellular_ion_concentrations__Cai; // millimolar
1019 pow(var_SERCA2a_pump__Cai / var_SERCA2a_pump__K_fb,
1020 var_SERCA2a_pump__N_fb); // dimensionless
1022 0.0813; // millimolar_per_second
1025 var_chaste_interface__intracellular_ion_concentrations__Ca_NSR; // millimolar
1029 pow(var_SERCA2a_pump__Ca_NSR / var_SERCA2a_pump__K_rb,
1030 var_SERCA2a_pump__N_rb); // dimensionless
1032 0.318; // millimolar_per_second
1034 (var_SERCA2a_pump__K_SR *
1035 ((var_SERCA2a_pump__Vmaxf * var_SERCA2a_pump__fb) -
1036 (var_SERCA2a_pump__Vmaxr * var_SERCA2a_pump__rb))) /
1037 (1.0 + var_SERCA2a_pump__fb +
1038 var_SERCA2a_pump__rb); // millimolar_per_second
1040 var_chaste_interface__intracellular_ion_concentrations__Ca_NSR; // millimolar
1042 var_chaste_interface__intracellular_ion_concentrations__Ca_JSR; // millimolar
1044 0.0005747; // second
1046 (var_intracellular_Ca_fluxes__Ca_NSR -
1047 var_intracellular_Ca_fluxes__Ca_JSR) /
1048 var_intracellular_Ca_fluxes__tau_tr; // millimolar_per_second
1050 var_chaste_interface__intracellular_ion_concentrations__Cai; // millimolar
1052 0.0267; // second
1054 var_chaste_interface__intracellular_ion_concentrations__Ca_ss; // millimolar
1056 (var_intracellular_Ca_fluxes__Ca_ss -
1057 var_intracellular_Ca_fluxes__Cai) /
1058 var_intracellular_Ca_fluxes__tau_xfer; // millimolar_per_second
1060 0.066; // per_second
1062 20000.0; // per_millimolar_second
1064 var_chaste_interface__intracellular_Ca_fluxes__HTRPNCa; // millimolar
1066 var_intracellular_Ca_fluxes__d_HTRPNCa_d_environment__time =
1067 (var_intracellular_Ca_fluxes__k_htrpn_plus *
1068 var_intracellular_Ca_fluxes__Cai *
1069 (1.0 - var_intracellular_Ca_fluxes__HTRPNCa)) -
1070 (var_intracellular_Ca_fluxes__k_htrpn_minus *
1071 var_intracellular_Ca_fluxes__HTRPNCa); // 'millimole per litre
1072 // per second'
1074 var_intracellular_Ca_fluxes__d_HTRPNCa_d_environment__time; // millimolar_per_second
1076 0.07; // dimensionless
1078 var_chaste_interface__intracellular_Ca_fluxes__LTRPNCa; // millimolar
1080 40.0; // per_second
1082 40000.0; // per_millimolar_second
1084 var_intracellular_Ca_fluxes__d_LTRPNCa_d_environment__time =
1085 (var_intracellular_Ca_fluxes__k_ltrpn_plus *
1086 var_intracellular_Ca_fluxes__Cai *
1087 (1.0 - var_intracellular_Ca_fluxes__LTRPNCa)) -
1088 (var_intracellular_Ca_fluxes__k_ltrpn_minus *
1089 var_intracellular_Ca_fluxes__LTRPNCa); // 'millimole per litre
1090 // per second'
1092 var_intracellular_Ca_fluxes__d_LTRPNCa_d_environment__time; // millimolar_per_second
1094 0.14; // dimensionless
1096 (var_intracellular_Ca_fluxes__HTRPN_tot *
1097 var_intracellular_Ca_fluxes__J_HTRPNCa) +
1098 (var_intracellular_Ca_fluxes__LTRPN_tot *
1099 var_intracellular_Ca_fluxes__J_LTRPNCa); // millimolar_per_second
1101 var_chaste_interface__intracellular_ion_concentrations__Cai; // millimolar
1103 var_chaste_interface__intracellular_ion_concentrations__Ca_ss; // millimolar
1105 var_chaste_interface__intracellular_ion_concentrations__Ca_JSR; // millimolar
1107 0.0001534; // cm2
1109 2.584e-05; // micro_litre
1111 1.6e-07; // micro_litre
1113 2.1e-06; // micro_litre
1115 1.2e-09; // micro_litre
1117 0.00238; // millimolar
1119 0.00015; // millimolar
1121 0.8; // millimolar
1123 0.05; // millimolar
1125 0.0; // millimolar
1127 15.0; // millimolar
1129 1.0 / (1.0 +
1130 ((var_intracellular_ion_concentrations__CMDN_tot *
1131 var_intracellular_ion_concentrations__K_mCMDN) /
1132 pow(var_intracellular_ion_concentrations__K_mCMDN +
1133 var_intracellular_ion_concentrations__Cai,
1134 2.0)) +
1135 ((var_intracellular_ion_concentrations__EGTA_tot *
1136 var_intracellular_ion_concentrations__K_mEGTA) /
1137 pow(var_intracellular_ion_concentrations__K_mEGTA +
1138 var_intracellular_ion_concentrations__Cai,
1139 2.0))); // dimensionless
1141 1.0 / (1.0 +
1142 ((var_intracellular_ion_concentrations__CMDN_tot *
1143 var_intracellular_ion_concentrations__K_mCMDN) /
1144 pow(var_intracellular_ion_concentrations__K_mCMDN +
1145 var_intracellular_ion_concentrations__Ca_ss,
1146 2.0)) +
1147 ((var_intracellular_ion_concentrations__EGTA_tot *
1148 var_intracellular_ion_concentrations__K_mEGTA) /
1149 pow(var_intracellular_ion_concentrations__K_mEGTA +
1150 var_intracellular_ion_concentrations__Ca_ss,
1151 2.0))); // dimensionless
1153 1.0 / (1.0 + ((var_intracellular_ion_concentrations__CSQN_tot *
1154 var_intracellular_ion_concentrations__K_mCSQN) /
1155 pow(var_intracellular_ion_concentrations__K_mCSQN +
1156 var_intracellular_ion_concentrations__Ca_JSR,
1157 2.0))); // dimensionless
1159 var_membrane__F; // coulomb_per_millimole
1161 var_fast_sodium_current__i_Na; // microA_per_microF
1163 var_L_type_Ca_current__i_Ca; // microA_per_microF
1165 var_sodium_background_current__i_Na_b; // microA_per_microF
1167 var_Na_Ca_exchanger__i_NaCa; // microA_per_microF
1169 var_sodium_potassium_pump__i_NaK; // microA_per_microF
1171 var_L_type_Ca_current__i_Ca_K; // microA_per_microF
1173 var_rapid_activating_delayed_rectifiyer_K_current__i_Kr; // microA_per_microF
1175 var_slow_activating_delayed_rectifiyer_K_current__i_Ks; // microA_per_microF
1177 var_time_independent_potassium_current__i_K1; // microA_per_microF
1179 var_plateau_potassium_current__i_Kp; // microA_per_microF
1181 var_transient_outward_potassium_current__i_to1; // microA_per_microF
1183 var_sarcolemmal_calcium_pump__i_p_Ca; // microA_per_microF
1185 var_calcium_background_current__i_Ca_b; // microA_per_microF
1187 var_SERCA2a_pump__J_up; // millimolar_per_second
1189 var_RyR_channel__J_rel; // millimolar_per_second
1191 var_intracellular_Ca_fluxes__J_xfer; // millimolar_per_second
1193 var_intracellular_Ca_fluxes__J_trpn; // millimolar_per_second
1195 var_intracellular_Ca_fluxes__J_tr; // millimolar_per_second
1197 var_intracellular_ion_concentrations__d_Nai_d_environment__time =
1198 ((-0.0) *
1199 (var_intracellular_ion_concentrations__i_Na +
1200 var_intracellular_ion_concentrations__i_Na_b +
1201 (var_intracellular_ion_concentrations__i_NaCa * 3.0) +
1202 (var_intracellular_ion_concentrations__i_NaK * 3.0)) *
1203 var_intracellular_ion_concentrations__A_cap * 1.0) /
1204 (var_intracellular_ion_concentrations__V_myo *
1205 var_intracellular_ion_concentrations__F); // 'millimole per
1206 // litre per second'
1208 var_intracellular_ion_concentrations__d_Cai_d_environment__time =
1209 var_intracellular_ion_concentrations__beta_i *
1210 ((var_intracellular_ion_concentrations__J_xfer -
1211 (var_intracellular_ion_concentrations__J_up +
1212 var_intracellular_ion_concentrations__J_trpn)) +
1213 ((((2.0 * var_intracellular_ion_concentrations__i_NaCa) -
1214 (var_intracellular_ion_concentrations__i_p_Ca +
1215 var_intracellular_ion_concentrations__i_Ca_b)) *
1216 var_intracellular_ion_concentrations__A_cap * 1.0) /
1217 (2.0 * var_intracellular_ion_concentrations__V_myo *
1218 var_intracellular_ion_concentrations__F))); // 'millimole per
1219 // litre per
1220 // second'
1222 var_intracellular_ion_concentrations__d_Ki_d_environment__time =
1223 ((-0.0) *
1224 (var_intracellular_ion_concentrations__i_Ca_K +
1225 var_intracellular_ion_concentrations__i_Kr +
1226 var_intracellular_ion_concentrations__i_Ks +
1227 var_intracellular_ion_concentrations__i_K1 +
1228 var_intracellular_ion_concentrations__i_Kp +
1229 var_intracellular_ion_concentrations__i_to1 +
1230 (var_intracellular_ion_concentrations__i_NaK * (-2.0))) *
1231 var_intracellular_ion_concentrations__A_cap * 1.0) /
1232 (var_intracellular_ion_concentrations__V_myo *
1233 var_intracellular_ion_concentrations__F); // 'millimole per
1234 // litre per second'
1236 var_intracellular_ion_concentrations__d_Ca_ss_d_environment__time =
1237 var_intracellular_ion_concentrations__beta_SS *
1238 ((((var_intracellular_ion_concentrations__J_rel *
1239 var_intracellular_ion_concentrations__V_JSR) /
1240 var_intracellular_ion_concentrations__V_SS) -
1241 ((var_intracellular_ion_concentrations__J_xfer *
1242 var_intracellular_ion_concentrations__V_myo) /
1243 var_intracellular_ion_concentrations__V_SS)) -
1244 ((var_intracellular_ion_concentrations__i_Ca *
1245 var_intracellular_ion_concentrations__A_cap * 1.0) /
1246 (2.0 * var_intracellular_ion_concentrations__V_SS *
1247 var_intracellular_ion_concentrations__F))); // 'millimole per
1248 // litre per
1249 // second'
1251 var_intracellular_ion_concentrations__d_Ca_JSR_d_environment__time =
1252 var_intracellular_ion_concentrations__beta_JSR *
1253 (var_intracellular_ion_concentrations__J_tr -
1254 var_intracellular_ion_concentrations__J_rel); // 'millimole per
1255 // litre per
1256 // second'
1258 var_intracellular_ion_concentrations__d_Ca_NSR_d_environment__time =
1259 ((var_intracellular_ion_concentrations__J_up *
1260 var_intracellular_ion_concentrations__V_myo) /
1261 var_intracellular_ion_concentrations__V_NSR) -
1262 ((var_intracellular_ion_concentrations__J_tr *
1263 var_intracellular_ion_concentrations__V_JSR) /
1264 var_intracellular_ion_concentrations__V_NSR); // 'millimole per
1265 // litre per
1266 // second'
1268 var_chaste_interface__fast_sodium_current_m_gate__d_m_d_environment__time_converter =
1269 var_fast_sodium_current__fast_sodium_current_m_gate__d_m_d_environment__time; // per_second
1271 var_chaste_interface__fast_sodium_current_m_gate__d_m_d_environment__time =
1272 0.001 *
1273 var_chaste_interface__fast_sodium_current_m_gate__d_m_d_environment__time_converter; // 'per millisecond'
1275 var_chaste_interface__fast_sodium_current_h_gate__d_h_d_environment__time_converter =
1276 var_fast_sodium_current__fast_sodium_current_h_gate__d_h_d_environment__time; // per_second
1278 var_chaste_interface__fast_sodium_current_h_gate__d_h_d_environment__time =
1279 0.001 *
1280 var_chaste_interface__fast_sodium_current_h_gate__d_h_d_environment__time_converter; // 'per millisecond'
1282 var_chaste_interface__fast_sodium_current_j_gate__d_j_d_environment__time_converter =
1283 var_fast_sodium_current__fast_sodium_current_j_gate__d_j_d_environment__time; // per_second
1285 var_chaste_interface__fast_sodium_current_j_gate__d_j_d_environment__time =
1286 0.001 *
1287 var_chaste_interface__fast_sodium_current_j_gate__d_j_d_environment__time_converter; // 'per millisecond'
1289 var_chaste_interface__rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__d_X_kr_d_environment__time_converter =
1290 var_rapid_activating_delayed_rectifiyer_K_current__rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__d_X_kr_d_environment__time; // per_second
1292 var_chaste_interface__rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__d_X_kr_d_environment__time =
1293 0.001 *
1294 var_chaste_interface__rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__d_X_kr_d_environment__time_converter; // 'per millisecond'
1296 var_chaste_interface__slow_activating_delayed_rectifiyer_K_current_X_ks_gate__d_X_ks_d_environment__time_converter =
1297 var_slow_activating_delayed_rectifiyer_K_current__slow_activating_delayed_rectifiyer_K_current_X_ks_gate__d_X_ks_d_environment__time; // per_second
1299 var_chaste_interface__slow_activating_delayed_rectifiyer_K_current_X_ks_gate__d_X_ks_d_environment__time =
1300 0.001 *
1301 var_chaste_interface__slow_activating_delayed_rectifiyer_K_current_X_ks_gate__d_X_ks_d_environment__time_converter; // 'per millisecond'
1303 var_chaste_interface__transient_outward_potassium_current_X_to1_gate__d_X_to1_d_environment__time_converter =
1304 var_transient_outward_potassium_current__transient_outward_potassium_current_X_to1_gate__d_X_to1_d_environment__time; // per_second
1306 var_chaste_interface__transient_outward_potassium_current_X_to1_gate__d_X_to1_d_environment__time =
1307 0.001 *
1308 var_chaste_interface__transient_outward_potassium_current_X_to1_gate__d_X_to1_d_environment__time_converter; // 'per millisecond'
1310 var_chaste_interface__transient_outward_potassium_current_Y_to1_gate__d_Y_to1_d_environment__time_converter =
1311 var_transient_outward_potassium_current__transient_outward_potassium_current_Y_to1_gate__d_Y_to1_d_environment__time; // per_second
1313 var_chaste_interface__transient_outward_potassium_current_Y_to1_gate__d_Y_to1_d_environment__time =
1314 0.001 *
1315 var_chaste_interface__transient_outward_potassium_current_Y_to1_gate__d_Y_to1_d_environment__time_converter; // 'per millisecond'
1317 var_chaste_interface__L_type_Ca_current__d_O_d_environment__time_converter =
1318 var_L_type_Ca_current__d_O_d_environment__time; // per_second
1320 var_chaste_interface__L_type_Ca_current__d_O_d_environment__time =
1321 0.001 *
1322 var_chaste_interface__L_type_Ca_current__d_O_d_environment__time_converter; // 'per millisecond'
1324 var_chaste_interface__L_type_Ca_current__d_O_Ca_d_environment__time_converter =
1325 var_L_type_Ca_current__d_O_Ca_d_environment__time; // per_second
1327 var_chaste_interface__L_type_Ca_current__d_O_Ca_d_environment__time =
1328 0.001 *
1329 var_chaste_interface__L_type_Ca_current__d_O_Ca_d_environment__time_converter; // 'per millisecond'
1331 var_chaste_interface__L_type_Ca_current__d_C0_d_environment__time_converter =
1332 var_L_type_Ca_current__d_C0_d_environment__time; // per_second
1334 var_chaste_interface__L_type_Ca_current__d_C0_d_environment__time =
1335 0.001 *
1336 var_chaste_interface__L_type_Ca_current__d_C0_d_environment__time_converter; // 'per millisecond'
1338 var_chaste_interface__L_type_Ca_current__d_C1_d_environment__time_converter =
1339 var_L_type_Ca_current__d_C1_d_environment__time; // per_second
1341 var_chaste_interface__L_type_Ca_current__d_C1_d_environment__time =
1342 0.001 *
1343 var_chaste_interface__L_type_Ca_current__d_C1_d_environment__time_converter; // 'per millisecond'
1345 var_chaste_interface__L_type_Ca_current__d_C2_d_environment__time_converter =
1346 var_L_type_Ca_current__d_C2_d_environment__time; // per_second
1348 var_chaste_interface__L_type_Ca_current__d_C2_d_environment__time =
1349 0.001 *
1350 var_chaste_interface__L_type_Ca_current__d_C2_d_environment__time_converter; // 'per millisecond'
1352 var_chaste_interface__L_type_Ca_current__d_C3_d_environment__time_converter =
1353 var_L_type_Ca_current__d_C3_d_environment__time; // per_second
1355 var_chaste_interface__L_type_Ca_current__d_C3_d_environment__time =
1356 0.001 *
1357 var_chaste_interface__L_type_Ca_current__d_C3_d_environment__time_converter; // 'per millisecond'
1359 var_chaste_interface__L_type_Ca_current__d_C4_d_environment__time_converter =
1360 var_L_type_Ca_current__d_C4_d_environment__time; // per_second
1362 var_chaste_interface__L_type_Ca_current__d_C4_d_environment__time =
1363 0.001 *
1364 var_chaste_interface__L_type_Ca_current__d_C4_d_environment__time_converter; // 'per millisecond'
1366 var_chaste_interface__L_type_Ca_current__d_C_Ca0_d_environment__time_converter =
1367 var_L_type_Ca_current__d_C_Ca0_d_environment__time; // per_second
1369 var_chaste_interface__L_type_Ca_current__d_C_Ca0_d_environment__time =
1370 0.001 *
1371 var_chaste_interface__L_type_Ca_current__d_C_Ca0_d_environment__time_converter; // 'per millisecond'
1373 var_chaste_interface__L_type_Ca_current__d_C_Ca1_d_environment__time_converter =
1374 var_L_type_Ca_current__d_C_Ca1_d_environment__time; // per_second
1376 var_chaste_interface__L_type_Ca_current__d_C_Ca1_d_environment__time =
1377 0.001 *
1378 var_chaste_interface__L_type_Ca_current__d_C_Ca1_d_environment__time_converter; // 'per millisecond'
1380 var_chaste_interface__L_type_Ca_current__d_C_Ca2_d_environment__time_converter =
1381 var_L_type_Ca_current__d_C_Ca2_d_environment__time; // per_second
1383 var_chaste_interface__L_type_Ca_current__d_C_Ca2_d_environment__time =
1384 0.001 *
1385 var_chaste_interface__L_type_Ca_current__d_C_Ca2_d_environment__time_converter; // 'per millisecond'
1387 var_chaste_interface__L_type_Ca_current__d_C_Ca3_d_environment__time_converter =
1388 var_L_type_Ca_current__d_C_Ca3_d_environment__time; // per_second
1390 var_chaste_interface__L_type_Ca_current__d_C_Ca3_d_environment__time =
1391 0.001 *
1392 var_chaste_interface__L_type_Ca_current__d_C_Ca3_d_environment__time_converter; // 'per millisecond'
1394 var_chaste_interface__L_type_Ca_current__d_C_Ca4_d_environment__time_converter =
1395 var_L_type_Ca_current__d_C_Ca4_d_environment__time; // per_second
1397 var_chaste_interface__L_type_Ca_current__d_C_Ca4_d_environment__time =
1398 0.001 *
1399 var_chaste_interface__L_type_Ca_current__d_C_Ca4_d_environment__time_converter; // 'per millisecond'
1401 var_chaste_interface__L_type_Ca_current_y_gate__d_y_d_environment__time_converter =
1402 var_L_type_Ca_current__L_type_Ca_current_y_gate__d_y_d_environment__time; // per_second
1404 var_chaste_interface__L_type_Ca_current_y_gate__d_y_d_environment__time =
1405 0.001 *
1406 var_chaste_interface__L_type_Ca_current_y_gate__d_y_d_environment__time_converter; // 'per millisecond'
1408 var_chaste_interface__RyR_channel__d_P_O1_d_environment__time_converter =
1409 var_RyR_channel__d_P_O1_d_environment__time; // per_second
1411 0.001 *
1412 var_chaste_interface__RyR_channel__d_P_O1_d_environment__time_converter; // 'per millisecond'
1414 var_chaste_interface__RyR_channel__d_P_O2_d_environment__time_converter =
1415 var_RyR_channel__d_P_O2_d_environment__time; // per_second
1417 0.001 *
1418 var_chaste_interface__RyR_channel__d_P_O2_d_environment__time_converter; // 'per millisecond'
1420 var_chaste_interface__RyR_channel__d_P_C1_d_environment__time_converter =
1421 var_RyR_channel__d_P_C1_d_environment__time; // per_second
1423 0.001 *
1424 var_chaste_interface__RyR_channel__d_P_C1_d_environment__time_converter; // 'per millisecond'
1426 var_chaste_interface__RyR_channel__d_P_C2_d_environment__time_converter =
1427 var_RyR_channel__d_P_C2_d_environment__time; // per_second
1429 0.001 *
1430 var_chaste_interface__RyR_channel__d_P_C2_d_environment__time_converter; // 'per millisecond'
1432 var_chaste_interface__intracellular_Ca_fluxes__d_HTRPNCa_d_environment__time_converter =
1433 var_intracellular_Ca_fluxes__d_HTRPNCa_d_environment__time; // ___units_89
1435 var_chaste_interface__intracellular_Ca_fluxes__d_HTRPNCa_d_environment__time =
1436 0.001 *
1437 var_chaste_interface__intracellular_Ca_fluxes__d_HTRPNCa_d_environment__time_converter; // 'millimolar per millisecond'
1439 var_chaste_interface__intracellular_Ca_fluxes__d_LTRPNCa_d_environment__time_converter =
1440 var_intracellular_Ca_fluxes__d_LTRPNCa_d_environment__time; // millimole_per_litre_per_second
1442 var_chaste_interface__intracellular_Ca_fluxes__d_LTRPNCa_d_environment__time =
1443 0.001 *
1444 var_chaste_interface__intracellular_Ca_fluxes__d_LTRPNCa_d_environment__time_converter; // 'millimolar per millisecond'
1446 var_chaste_interface__intracellular_ion_concentrations__d_Nai_d_environment__time_converter =
1447 var_intracellular_ion_concentrations__d_Nai_d_environment__time; // millimole_per_litre_per_second
1449 var_chaste_interface__intracellular_ion_concentrations__d_Nai_d_environment__time =
1450 0.001 *
1451 var_chaste_interface__intracellular_ion_concentrations__d_Nai_d_environment__time_converter; // 'millimolar per millisecond'
1453 var_chaste_interface__intracellular_ion_concentrations__d_Cai_d_environment__time_converter =
1454 var_intracellular_ion_concentrations__d_Cai_d_environment__time; // millimole_per_litre_per_second
1456 var_chaste_interface__intracellular_ion_concentrations__d_Cai_d_environment__time =
1457 0.001 *
1458 var_chaste_interface__intracellular_ion_concentrations__d_Cai_d_environment__time_converter; // 'millimolar per millisecond'
1460 var_chaste_interface__intracellular_ion_concentrations__d_Ki_d_environment__time_converter =
1461 var_intracellular_ion_concentrations__d_Ki_d_environment__time; // millimole_per_litre_per_second
1463 var_chaste_interface__intracellular_ion_concentrations__d_Ki_d_environment__time =
1464 0.001 *
1465 var_chaste_interface__intracellular_ion_concentrations__d_Ki_d_environment__time_converter; // 'millimolar per millisecond'
1467 var_chaste_interface__intracellular_ion_concentrations__d_Ca_ss_d_environment__time_converter =
1468 var_intracellular_ion_concentrations__d_Ca_ss_d_environment__time; // millimole_per_litre_per_second
1470 var_chaste_interface__intracellular_ion_concentrations__d_Ca_ss_d_environment__time =
1471 0.001 *
1472 var_chaste_interface__intracellular_ion_concentrations__d_Ca_ss_d_environment__time_converter; // 'millimolar per millisecond'
1474 var_chaste_interface__intracellular_ion_concentrations__d_Ca_JSR_d_environment__time_converter =
1475 var_intracellular_ion_concentrations__d_Ca_JSR_d_environment__time; // millimole_per_litre_per_second
1477 var_chaste_interface__intracellular_ion_concentrations__d_Ca_JSR_d_environment__time =
1478 0.001 *
1479 var_chaste_interface__intracellular_ion_concentrations__d_Ca_JSR_d_environment__time_converter; // 'millimolar per millisecond'
1481 var_chaste_interface__intracellular_ion_concentrations__d_Ca_NSR_d_environment__time_converter =
1482 var_intracellular_ion_concentrations__d_Ca_NSR_d_environment__time; // millimole_per_litre_per_second
1484 var_chaste_interface__intracellular_ion_concentrations__d_Ca_NSR_d_environment__time =
1485 0.001 *
1486 var_chaste_interface__intracellular_ion_concentrations__d_Ca_NSR_d_environment__time_converter; // 'millimolar per millisecond'
1488 var_chaste_interface__fast_sodium_current_m_gate__d_m_d_environment__time; // 'per millisecond'
1490 var_chaste_interface__fast_sodium_current_h_gate__d_h_d_environment__time; // 'per millisecond'
1492 var_chaste_interface__fast_sodium_current_j_gate__d_j_d_environment__time; // 'per millisecond'
1494 d_dt_chaste_interface__rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__X_kr =
1495 var_chaste_interface__rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__d_X_kr_d_environment__time; // 'per millisecond'
1497 d_dt_chaste_interface__slow_activating_delayed_rectifiyer_K_current_X_ks_gate__X_ks =
1498 var_chaste_interface__slow_activating_delayed_rectifiyer_K_current_X_ks_gate__d_X_ks_d_environment__time; // 'per millisecond'
1500 d_dt_chaste_interface__transient_outward_potassium_current_X_to1_gate__X_to1 =
1501 var_chaste_interface__transient_outward_potassium_current_X_to1_gate__d_X_to1_d_environment__time; // 'per millisecond'
1503 d_dt_chaste_interface__transient_outward_potassium_current_Y_to1_gate__Y_to1 =
1504 var_chaste_interface__transient_outward_potassium_current_Y_to1_gate__d_Y_to1_d_environment__time; // 'per millisecond'
1506 var_chaste_interface__L_type_Ca_current__d_O_d_environment__time; // 'per millisecond'
1508 var_chaste_interface__L_type_Ca_current__d_O_Ca_d_environment__time; // 'per millisecond'
1510 var_chaste_interface__L_type_Ca_current__d_C0_d_environment__time; // 'per millisecond'
1512 var_chaste_interface__L_type_Ca_current__d_C1_d_environment__time; // 'per millisecond'
1514 var_chaste_interface__L_type_Ca_current__d_C2_d_environment__time; // 'per millisecond'
1516 var_chaste_interface__L_type_Ca_current__d_C3_d_environment__time; // 'per millisecond'
1518 var_chaste_interface__L_type_Ca_current__d_C4_d_environment__time; // 'per millisecond'
1520 var_chaste_interface__L_type_Ca_current__d_C_Ca0_d_environment__time; // 'per millisecond'
1522 var_chaste_interface__L_type_Ca_current__d_C_Ca1_d_environment__time; // 'per millisecond'
1524 var_chaste_interface__L_type_Ca_current__d_C_Ca2_d_environment__time; // 'per millisecond'
1526 var_chaste_interface__L_type_Ca_current__d_C_Ca3_d_environment__time; // 'per millisecond'
1528 var_chaste_interface__L_type_Ca_current__d_C_Ca4_d_environment__time; // 'per millisecond'
1530 var_chaste_interface__L_type_Ca_current_y_gate__d_y_d_environment__time; // 'per millisecond'
1532 var_chaste_interface__RyR_channel__d_P_O1_d_environment__time; // 'per
1533 // millisecond'
1535 var_chaste_interface__RyR_channel__d_P_O2_d_environment__time; // 'per
1536 // millisecond'
1538 var_chaste_interface__RyR_channel__d_P_C1_d_environment__time; // 'per
1539 // millisecond'
1541 var_chaste_interface__RyR_channel__d_P_C2_d_environment__time; // 'per
1542 // millisecond'
1544 var_chaste_interface__intracellular_Ca_fluxes__d_HTRPNCa_d_environment__time; // 'millimole per litre per millisecond'
1546 var_chaste_interface__intracellular_Ca_fluxes__d_LTRPNCa_d_environment__time; // 'millimole per litre per millisecond'
1548 var_chaste_interface__intracellular_ion_concentrations__d_Nai_d_environment__time; // 'millimole per litre per millisecond'
1550 var_chaste_interface__intracellular_ion_concentrations__d_Cai_d_environment__time; // 'millimole per litre per millisecond'
1552 var_chaste_interface__intracellular_ion_concentrations__d_Ki_d_environment__time; // 'millimole per litre per millisecond'
1554 d_dt_chaste_interface__intracellular_ion_concentrations__Ca_ss =
1555 var_chaste_interface__intracellular_ion_concentrations__d_Ca_ss_d_environment__time; // 'millimole per litre per millisecond'
1557 d_dt_chaste_interface__intracellular_ion_concentrations__Ca_JSR =
1558 var_chaste_interface__intracellular_ion_concentrations__d_Ca_JSR_d_environment__time; // 'millimole per litre per millisecond'
1560 d_dt_chaste_interface__intracellular_ion_concentrations__Ca_NSR =
1561 var_chaste_interface__intracellular_ion_concentrations__d_Ca_NSR_d_environment__time; // 'millimole per litre per millisecond'
1562
1565 var_fast_sodium_current__i_Na; // microA_per_microF
1567 var_L_type_Ca_current__i_Ca; // microA_per_microF
1569 var_L_type_Ca_current__i_Ca_K; // microA_per_microF
1571 var_rapid_activating_delayed_rectifiyer_K_current__i_Kr; // microA_per_microF
1573 var_slow_activating_delayed_rectifiyer_K_current__i_Ks; // microA_per_microF
1575 var_transient_outward_potassium_current__i_to1; // microA_per_microF
1577 var_time_independent_potassium_current__i_K1; // microA_per_microF
1579 var_plateau_potassium_current__i_Kp; // microA_per_microF
1581 var_Na_Ca_exchanger__i_NaCa; // microA_per_microF
1583 var_sodium_potassium_pump__i_NaK; // microA_per_microF
1585 var_sarcolemmal_calcium_pump__i_p_Ca; // microA_per_microF
1587 var_calcium_background_current__i_Ca_b; // microA_per_microF
1589 var_sodium_background_current__i_Na_b; // microA_per_microF
1592 var_chaste_interface__membrane__i_Stim; // uA_per_cm2
1594 var_membrane__chaste_interface__chaste_membrane_capacitance =
1595 1.0; // uF_per_cm2
1597 var_membrane__i_Stim_converter /
1598 var_membrane__chaste_interface__chaste_membrane_capacitance; // microA_per_microF
1600 ((-1.0) * 1.0 *
1601 (var_membrane__i_Na + var_membrane__i_Ca + var_membrane__i_Ca_K +
1602 var_membrane__i_Kr + var_membrane__i_Ks + var_membrane__i_to1 +
1603 var_membrane__i_K1 + var_membrane__i_Kp + var_membrane__i_NaCa +
1604 var_membrane__i_NaK + var_membrane__i_p_Ca +
1605 var_membrane__i_Na_b + var_membrane__i_Ca_b +
1606 var_membrane__i_Stim)) /
1607 var_membrane__C_sc; // 'millivolt per second'
1609 var_chaste_interface__membrane__d_V_d_environment__time_converter =
1610 var_membrane__d_V_d_environment__time; // ___units_1
1612 0.001 *
1613 var_chaste_interface__membrane__d_V_d_environment__time_converter; // 'millivolt per millisecond'
1614 d_dt_chaste_interface__membrane__V =
1615 var_chaste_interface__membrane__d_V_d_environment__time; // 'millivolt
1616 // per
1617 // millisecond'
1618 outarray[0][i] = d_dt_chaste_interface__membrane__V;
1619 outarray[1][i] = d_dt_chaste_interface__fast_sodium_current_m_gate__m;
1620 outarray[2][i] = d_dt_chaste_interface__fast_sodium_current_h_gate__h;
1621 outarray[3][i] = d_dt_chaste_interface__fast_sodium_current_j_gate__j;
1622 outarray[4][i] =
1623 d_dt_chaste_interface__rapid_activating_delayed_rectifiyer_K_current_X_kr_gate__X_kr;
1624 outarray[5][i] =
1625 d_dt_chaste_interface__slow_activating_delayed_rectifiyer_K_current_X_ks_gate__X_ks;
1626 outarray[6][i] =
1627 d_dt_chaste_interface__transient_outward_potassium_current_X_to1_gate__X_to1;
1628 outarray[7][i] =
1629 d_dt_chaste_interface__transient_outward_potassium_current_Y_to1_gate__Y_to1;
1630 outarray[8][i] = d_dt_chaste_interface__L_type_Ca_current__O;
1631 outarray[9][i] = d_dt_chaste_interface__L_type_Ca_current__O_Ca;
1632 outarray[10][i] = d_dt_chaste_interface__L_type_Ca_current__C0;
1633 outarray[11][i] = d_dt_chaste_interface__L_type_Ca_current__C1;
1634 outarray[12][i] = d_dt_chaste_interface__L_type_Ca_current__C2;
1635 outarray[13][i] = d_dt_chaste_interface__L_type_Ca_current__C3;
1636 outarray[14][i] = d_dt_chaste_interface__L_type_Ca_current__C4;
1637 outarray[15][i] = d_dt_chaste_interface__L_type_Ca_current__C_Ca0;
1638 outarray[16][i] = d_dt_chaste_interface__L_type_Ca_current__C_Ca1;
1639 outarray[17][i] = d_dt_chaste_interface__L_type_Ca_current__C_Ca2;
1640 outarray[18][i] = d_dt_chaste_interface__L_type_Ca_current__C_Ca3;
1641 outarray[19][i] = d_dt_chaste_interface__L_type_Ca_current__C_Ca4;
1642 outarray[20][i] = d_dt_chaste_interface__L_type_Ca_current_y_gate__y;
1643 outarray[21][i] = d_dt_chaste_interface__RyR_channel__P_O1;
1644 outarray[22][i] = d_dt_chaste_interface__RyR_channel__P_O2;
1645 outarray[23][i] = d_dt_chaste_interface__RyR_channel__P_C1;
1646 outarray[24][i] = d_dt_chaste_interface__RyR_channel__P_C2;
1647 outarray[25][i] =
1648 d_dt_chaste_interface__intracellular_Ca_fluxes__HTRPNCa;
1649 outarray[26][i] =
1650 d_dt_chaste_interface__intracellular_Ca_fluxes__LTRPNCa;
1651 outarray[27][i] =
1652 d_dt_chaste_interface__intracellular_ion_concentrations__Nai;
1653 outarray[28][i] =
1654 d_dt_chaste_interface__intracellular_ion_concentrations__Cai;
1655 outarray[29][i] =
1656 d_dt_chaste_interface__intracellular_ion_concentrations__Ki;
1657 outarray[30][i] =
1658 d_dt_chaste_interface__intracellular_ion_concentrations__Ca_ss;
1659 outarray[31][i] =
1660 d_dt_chaste_interface__intracellular_ion_concentrations__Ca_JSR;
1661 outarray[32][i] =
1662 d_dt_chaste_interface__intracellular_ion_concentrations__Ca_NSR;
1663 }
1664}
References tinysimd::log(), Nektar::CellModel::m_nq, and tinysimd::sqrt().
Member Data Documentation
◆ className
|
static |
Initial value:
=
tKey RegisterCreatorFunction(tKey idKey, CreatorFunction classCreator, std::string pDesc="")
Register a class with the factory.
Definition: NekFactory.hpp:197
static CellModelSharedPtr create(const LibUtilities::SessionReaderSharedPtr &pSession, const MultiRegions::ExpListSharedPtr &pField)
Creates an instance of this class.
Definition: Winslow99.h:47
Name of class.
Definition at line 55 of file Winslow99.h.
