PanditGilesDemir03.cpp

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///////////////////////////////////////////////////////////////////////////////
//
// File: PanditGilesDemir03.cpp
//
// For more information, please see: http://www.nektar.info
//
// The MIT License
//
// Copyright (c) 2006 Division of Applied Mathematics, Brown University (USA),
// Department of Aeronautics, Imperial College London (UK), and Scientific
// Computing and Imaging Institute, University of Utah (USA).
//
// Permission is hereby granted, free of charge, to any person obtaining a
// copy of this software and associated documentation files (the "Software"),
// to deal in the Software without restriction, including without limitation
// the rights to use, copy, modify, merge, publish, distribute, sublicense,
// and/or sell copies of the Software, and to permit persons to whom the
// Software is furnished to do so, subject to the following conditions:
//
// The above copyright notice and this permission notice shall be included
// in all copies or substantial portions of the Software.
//
// THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS
// OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
// FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL
// THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
// LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING
// FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER
// DEALINGS IN THE SOFTWARE.
//
// Description: Pandit-Giles-Demir 2003 cell model
//
///////////////////////////////////////////////////////////////////////////////
 
#include <CardiacEPSolver/CellModels/PanditGilesDemir03.h>
#include <LibUtilities/BasicUtils/Vmath.hpp>
#include <iostream>
#include <string>
 
namespace Nektar
{
std::string PanditGilesDemir03::className =
    GetCellModelFactory().RegisterCreatorFunction(
        "PanditGilesDemir03", PanditGilesDemir03::create,
        "Pandit-Giles-Demir 2003 cell model.");
 
/**
 *
 */
PanditGilesDemir03::PanditGilesDemir03(
    const LibUtilities::SessionReaderSharedPtr &pSession,
    const MultiRegions::ExpListSharedPtr &pField)
    : CellModel(pSession, pField)
{
}
 
void PanditGilesDemir03::v_Update(
    const Array<OneD, const Array<OneD, NekDouble>> &inarray,
    Array<OneD, Array<OneD, NekDouble>> &outarray,
    [[maybe_unused]] const NekDouble time)
{
    for (size_t i = 0; i < m_nq; ++i)
    {
        // Inputs:
        // Time units: millisecond
        NekDouble var_chaste_interface__membrane__V = inarray[0][i];
        // Units: millivolt; Initial value: -80.50146
        NekDouble var_chaste_interface__sodium_current_m_gate__m =
            inarray[2][i];
        // Units: dimensionless; Initial value: 0.004164108
        NekDouble var_chaste_interface__sodium_current_h_gate__h =
            inarray[3][i];
        // Units: dimensionless; Initial value: 0.6735613
        NekDouble var_chaste_interface__sodium_current_j_gate__j =
            inarray[4][i];
        // Units: dimensionless; Initial value: 0.6729362
        NekDouble var_chaste_interface__L_type_Ca_channel_d_gate__d =
            inarray[5][i];
        // Units: dimensionless; Initial value: 0.000002171081
        NekDouble var_chaste_interface__L_type_Ca_channel_f_11_gate__f_11 =
            inarray[6][i];
        // Units: dimensionless; Initial value: 0.9999529
        NekDouble var_chaste_interface__L_type_Ca_channel_f_12_gate__f_12 =
            inarray[7][i];
        // Units: dimensionless; Initial value: 0.9999529
        NekDouble
            var_chaste_interface__L_type_Ca_channel_Ca_inact_gate__Ca_inact =
                inarray[8][i];
        // Units: dimensionless; Initial value: 0.9913102
        NekDouble
            var_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__r =
                inarray[9][i];
        // Units: dimensionless; Initial value: 0.002191519
        NekDouble
            var_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__s =
                inarray[10][i];
        // Units: dimensionless; Initial value: 0.9842542
        NekDouble
            var_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__s_slow =
                inarray[11][i];
        // Units: dimensionless; Initial value: 0.6421196
        NekDouble
            var_chaste_interface__steady_state_outward_K_current_r_ss_gate__r_ss =
                inarray[12][i];
        // Units: dimensionless; Initial value: 0.002907171
        NekDouble
            var_chaste_interface__steady_state_outward_K_current_s_ss_gate__s_ss =
                inarray[13][i];
        // Units: dimensionless; Initial value: 0.3142767
        NekDouble
            var_chaste_interface__hyperpolarisation_activated_current_y_gate__y =
                inarray[14][i];
        // Units: dimensionless; Initial value: 0.003578708
        NekDouble var_chaste_interface__SR_Ca_release_channel__P_O1 =
            inarray[15][i];
        // Units: dimensionless; Initial value: 0.0004327548
        NekDouble var_chaste_interface__SR_Ca_release_channel__P_O2 =
            inarray[16][i];
        // Units: dimensionless; Initial value: 0.000000000606254
        NekDouble var_chaste_interface__SR_Ca_release_channel__P_C1 =
            inarray[17][i];
        // Units: dimensionless; Initial value: 0.6348229
        NekDouble var_chaste_interface__SR_Ca_release_channel__P_C2 =
            inarray[18][i];
        // Units: dimensionless; Initial value: 0.3647471
        NekDouble
            var_chaste_interface__intracellular_and_SR_Ca_fluxes__HTRPNCa =
                inarray[19][i];
        // Units: millimolar; Initial value: 1.394301e-1
        NekDouble
            var_chaste_interface__intracellular_and_SR_Ca_fluxes__LTRPNCa =
                inarray[20][i];
        // Units: millimolar; Initial value: 5.1619e-3
        NekDouble var_chaste_interface__intracellular_ion_concentrations__Na_i =
            inarray[21][i];
        // Units: millimolar; Initial value: 10.73519
        NekDouble var_chaste_interface__intracellular_ion_concentrations__Ca_i =
            inarray[22][i];
        // Units: millimolar; Initial value: 0.00007901351
        NekDouble var_chaste_interface__intracellular_ion_concentrations__K_i =
            inarray[23][i];
        // Units: millimolar; Initial value: 139.2751
        NekDouble
            var_chaste_interface__intracellular_ion_concentrations__Ca_ss =
                inarray[24][i];
        // Units: millimolar; Initial value: 0.00008737212
        NekDouble
            var_chaste_interface__intracellular_ion_concentrations__Ca_JSR =
                inarray[25][i];
        // Units: millimolar; Initial value: 0.06607948
        NekDouble
            var_chaste_interface__intracellular_ion_concentrations__Ca_NSR =
                inarray[26][i];
        // Units: millimolar; Initial value: 0.06600742
 
        // Mathematics
        NekDouble d_dt_chaste_interface__membrane__V;
        const NekDouble var_membrane__R = 8314.5;  // millijoule_per_mole_kelvin
        const NekDouble var_membrane__T = 295.0;   // kelvin
        const NekDouble var_membrane__F = 96487.0; // coulomb_per_mole
        const NekDouble var_sodium_current__F =
            var_membrane__F; // coulomb_per_mole
        const NekDouble var_standard_ionic_concentrations__Na_o =
            140.0; // millimolar
        const NekDouble var_sodium_current__Na_o =
            var_standard_ionic_concentrations__Na_o;             // millimolar
        const NekDouble var_sodium_current__T = var_membrane__T; // kelvin
        const NekDouble var_sodium_current__R =
            var_membrane__R; // millijoule_per_mole_kelvin
        const NekDouble var_sodium_current__Na_i =
            var_chaste_interface__intracellular_ion_concentrations__Na_i; // millimolar
        const NekDouble var_sodium_current__E_Na =
            ((var_sodium_current__R * var_sodium_current__T) /
             var_sodium_current__F) *
            log(var_sodium_current__Na_o /
                var_sodium_current__Na_i); // millivolt
        const NekDouble var_sodium_current__m =
            var_chaste_interface__sodium_current_m_gate__m; // dimensionless
        const NekDouble var_sodium_current__j =
            var_chaste_interface__sodium_current_j_gate__j; // dimensionless
        const NekDouble var_sodium_current__h =
            var_chaste_interface__sodium_current_h_gate__h; // dimensionless
        const NekDouble var_sodium_current__V =
            var_chaste_interface__membrane__V;            // millivolt
        const NekDouble var_sodium_current__g_Na = 1.064; // microS
        const NekDouble var_sodium_current__i_Na =
            var_sodium_current__g_Na * pow(var_sodium_current__m, 3.0) *
            var_sodium_current__h * var_sodium_current__j *
            (var_sodium_current__V - var_sodium_current__E_Na); // nanoA
        const NekDouble var_L_type_Ca_channel__d =
            var_chaste_interface__L_type_Ca_channel_d_gate__d; // dimensionless
        const NekDouble var_L_type_Ca_channel__E_Ca_L = 65.0;  // millivolt
        const NekDouble var_L_type_Ca_channel__g_Ca_L_normal = 0.0341; // microS
        const NekDouble var_membrane__Diabetes = 0.0; // dimensionless
        const NekDouble var_L_type_Ca_channel__Diabetes =
            var_membrane__Diabetes; // dimensionless
        const NekDouble var_L_type_Ca_channel__g_Ca_L =
            (var_L_type_Ca_channel__Diabetes == 0.0)
                ? var_L_type_Ca_channel__g_Ca_L_normal
                : (0.76 * var_L_type_Ca_channel__g_Ca_L_normal); // microS
        const NekDouble var_L_type_Ca_channel__f_12 =
            var_chaste_interface__L_type_Ca_channel_f_12_gate__f_12; // dimensionless
        const NekDouble var_L_type_Ca_channel__f_11 =
            var_chaste_interface__L_type_Ca_channel_f_11_gate__f_11; // dimensionless
        const NekDouble var_L_type_Ca_channel__V =
            var_chaste_interface__membrane__V; // millivolt
        const NekDouble var_L_type_Ca_channel__Ca_inact =
            var_chaste_interface__L_type_Ca_channel_Ca_inact_gate__Ca_inact; // dimensionless
        const NekDouble var_L_type_Ca_channel__i_Ca_L =
            var_L_type_Ca_channel__g_Ca_L * var_L_type_Ca_channel__d *
            (((0.9 + (var_L_type_Ca_channel__Ca_inact / 10.0)) *
              var_L_type_Ca_channel__f_11) +
             ((0.1 - (var_L_type_Ca_channel__Ca_inact / 10.0)) *
              var_L_type_Ca_channel__f_12)) *
            (var_L_type_Ca_channel__V - var_L_type_Ca_channel__E_Ca_L); // nanoA
        const NekDouble
            var_Ca_independent_transient_outward_K_current__Diabetes =
                var_membrane__Diabetes; // dimensionless
        const NekDouble var_Ca_independent_transient_outward_K_current__b =
            (var_Ca_independent_transient_outward_K_current__Diabetes == 0.0)
                ? 0.114
                : 0.31; // dimensionless
        const NekDouble var_Ca_independent_transient_outward_K_current__a =
            1.0 -
            var_Ca_independent_transient_outward_K_current__b; // dimensionless
        const NekDouble
            var_Ca_independent_transient_outward_K_current__g_t_normal =
                0.04375; // microS
        const NekDouble var_Ca_independent_transient_outward_K_current__g_t =
            (var_Ca_independent_transient_outward_K_current__Diabetes == 0.0)
                ? var_Ca_independent_transient_outward_K_current__g_t_normal
                : (0.68 *
                   var_Ca_independent_transient_outward_K_current__g_t_normal); // microS
        const NekDouble var_Ca_independent_transient_outward_K_current__V =
            var_chaste_interface__membrane__V; // millivolt
        const NekDouble var_Ca_independent_transient_outward_K_current__r =
            var_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__r; // dimensionless
        const NekDouble var_Ca_independent_transient_outward_K_current__s =
            var_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__s; // dimensionless
        const NekDouble var_Ca_independent_transient_outward_K_current__F =
            var_membrane__F; // coulomb_per_mole
        const NekDouble var_Ca_independent_transient_outward_K_current__T =
            var_membrane__T; // kelvin
        const NekDouble var_Ca_independent_transient_outward_K_current__K_i =
            var_chaste_interface__intracellular_ion_concentrations__K_i; // millimolar
        const NekDouble var_Ca_independent_transient_outward_K_current__R =
            var_membrane__R; // millijoule_per_mole_kelvin
        const NekDouble var_standard_ionic_concentrations__K_o =
            5.4; // millimolar
        const NekDouble var_Ca_independent_transient_outward_K_current__K_o =
            var_standard_ionic_concentrations__K_o; // millimolar
        const NekDouble var_Ca_independent_transient_outward_K_current__E_K =
            ((var_Ca_independent_transient_outward_K_current__R *
              var_Ca_independent_transient_outward_K_current__T) /
             var_Ca_independent_transient_outward_K_current__F) *
            log(var_Ca_independent_transient_outward_K_current__K_o /
                var_Ca_independent_transient_outward_K_current__K_i); // millivolt
        const NekDouble var_Ca_independent_transient_outward_K_current__s_slow =
            var_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__s_slow; // dimensionless
        const NekDouble var_Ca_independent_transient_outward_K_current__i_t =
            var_Ca_independent_transient_outward_K_current__g_t *
            var_Ca_independent_transient_outward_K_current__r *
            ((var_Ca_independent_transient_outward_K_current__a *
              var_Ca_independent_transient_outward_K_current__s) +
             (var_Ca_independent_transient_outward_K_current__b *
              var_Ca_independent_transient_outward_K_current__s_slow)) *
            (var_Ca_independent_transient_outward_K_current__V -
             var_Ca_independent_transient_outward_K_current__E_K); // nanoA
        const NekDouble var_steady_state_outward_K_current__V =
            var_chaste_interface__membrane__V; // millivolt
        const NekDouble var_steady_state_outward_K_current__s_ss =
            var_chaste_interface__steady_state_outward_K_current_s_ss_gate__s_ss; // dimensionless
        const NekDouble var_steady_state_outward_K_current__E_K =
            var_Ca_independent_transient_outward_K_current__E_K; // millivolt
        const NekDouble var_steady_state_outward_K_current__g_ss_normal =
            0.0077; // microS
        const NekDouble var_steady_state_outward_K_current__Diabetes =
            var_membrane__Diabetes; // dimensionless
        const NekDouble var_steady_state_outward_K_current__g_ss =
            (var_steady_state_outward_K_current__Diabetes == 0.0)
                ? var_steady_state_outward_K_current__g_ss_normal
                : (0.77 *
                   var_steady_state_outward_K_current__g_ss_normal); // microS
        const NekDouble var_steady_state_outward_K_current__r_ss =
            var_chaste_interface__steady_state_outward_K_current_r_ss_gate__r_ss; // dimensionless
        const NekDouble var_steady_state_outward_K_current__i_ss =
            var_steady_state_outward_K_current__g_ss *
            var_steady_state_outward_K_current__r_ss *
            var_steady_state_outward_K_current__s_ss *
            (var_steady_state_outward_K_current__V -
             var_steady_state_outward_K_current__E_K); // nanoA
        const NekDouble var_hyperpolarisation_activated_current__f_Na =
            0.2; // dimensionless
        const NekDouble var_hyperpolarisation_activated_current__E_Na =
            var_sodium_current__E_Na; // millivolt
        const NekDouble var_hyperpolarisation_activated_current__y =
            var_chaste_interface__hyperpolarisation_activated_current_y_gate__y; // dimensionless
        const NekDouble var_hyperpolarisation_activated_current__V =
            var_chaste_interface__membrane__V; // millivolt
        const NekDouble var_hyperpolarisation_activated_current__g_f =
            0.00145; // microS
        const NekDouble var_hyperpolarisation_activated_current__i_f_Na =
            var_hyperpolarisation_activated_current__g_f *
            var_hyperpolarisation_activated_current__y *
            var_hyperpolarisation_activated_current__f_Na *
            (var_hyperpolarisation_activated_current__V -
             var_hyperpolarisation_activated_current__E_Na); // nanoA
        const NekDouble var_hyperpolarisation_activated_current__f_K =
            1.0 -
            var_hyperpolarisation_activated_current__f_Na; // dimensionless
        const NekDouble var_hyperpolarisation_activated_current__E_K =
            var_Ca_independent_transient_outward_K_current__E_K; // millivolt
        const NekDouble var_hyperpolarisation_activated_current__i_f_K =
            var_hyperpolarisation_activated_current__g_f *
            var_hyperpolarisation_activated_current__y *
            var_hyperpolarisation_activated_current__f_K *
            (var_hyperpolarisation_activated_current__V -
             var_hyperpolarisation_activated_current__E_K);        // nanoA
        const NekDouble var_inward_rectifier__T = var_membrane__T; // kelvin
        const NekDouble var_inward_rectifier__V =
            var_chaste_interface__membrane__V;              // millivolt
        const NekDouble var_inward_rectifier__g_K1 = 0.024; // microS
        const NekDouble var_inward_rectifier__R =
            var_membrane__R; // millijoule_per_mole_kelvin
        const NekDouble var_inward_rectifier__K_o =
            var_standard_ionic_concentrations__K_o; // millimolar
        const NekDouble var_inward_rectifier__F =
            var_membrane__F; // coulomb_per_mole
        const NekDouble var_inward_rectifier__E_K =
            var_Ca_independent_transient_outward_K_current__E_K; // millivolt
        const NekDouble var_inward_rectifier__i_K1 =
            ((((48.0 / (exp((var_inward_rectifier__V + 37.0) / 25.0) +
                        exp((var_inward_rectifier__V + 37.0) / (-25.0)))) +
               10.0) *
              0.0001) /
             (1.0 + exp((var_inward_rectifier__V -
                         (var_inward_rectifier__E_K + 76.77)) /
                        (-17.0)))) +
            ((var_inward_rectifier__g_K1 *
              (var_inward_rectifier__V - (var_inward_rectifier__E_K + 1.73))) /
             ((1.0 + exp((1.613 * var_inward_rectifier__F *
                          (var_inward_rectifier__V -
                           (var_inward_rectifier__E_K + 1.73))) /
                         (var_inward_rectifier__R * var_inward_rectifier__T))) *
              (1.0 +
               exp((var_inward_rectifier__K_o - 0.9988) / (-0.124))))); // nanoA
        const NekDouble var_background_currents__R =
            var_membrane__R; // millijoule_per_mole_kelvin
        const NekDouble var_background_currents__Ca_i =
            var_chaste_interface__intracellular_ion_concentrations__Ca_i; // millimolar
        const NekDouble var_standard_ionic_concentrations__Ca_o =
            1.2; // millimolar
        const NekDouble var_background_currents__Ca_o =
            var_standard_ionic_concentrations__Ca_o; // millimolar
        const NekDouble var_background_currents__F =
            var_membrane__F; // coulomb_per_mole
        const NekDouble var_background_currents__T = var_membrane__T; // kelvin
        const NekDouble var_background_currents__E_Ca =
            ((0.5 * var_background_currents__R * var_background_currents__T) /
             var_background_currents__F) *
            log(var_background_currents__Ca_o /
                var_background_currents__Ca_i); // millivolt
        const NekDouble var_background_currents__V =
            var_chaste_interface__membrane__V; // millivolt
        const NekDouble var_background_currents__g_B_Ca_normal =
            3.24e-05; // microS
        const NekDouble var_background_currents__Diabetes =
            var_membrane__Diabetes; // dimensionless
        const NekDouble var_background_currents__g_B_Ca =
            (var_background_currents__Diabetes == 0.0)
                ? var_background_currents__g_B_Ca_normal
                : (0.5 * var_background_currents__g_B_Ca_normal); // microS
        const NekDouble var_background_currents__i_B_Ca =
            var_background_currents__g_B_Ca *
            (var_background_currents__V -
             var_background_currents__E_Ca);                       // nanoA
        const NekDouble var_background_currents__g_B_K = 0.000138; // microS
        const NekDouble var_background_currents__E_K =
            var_Ca_independent_transient_outward_K_current__E_K; // millivolt
        const NekDouble var_background_currents__i_B_K =
            var_background_currents__g_B_K *
            (var_background_currents__V -
             var_background_currents__E_K); // nanoA
        const NekDouble var_background_currents__E_Na =
            var_sodium_current__E_Na; // millivolt
        const NekDouble var_background_currents__g_B_Na_normal =
            8.015e-05; // microS
        const NekDouble var_background_currents__g_B_Na =
            (var_background_currents__Diabetes == 0.0)
                ? var_background_currents__g_B_Na_normal
                : (1.25 * var_background_currents__g_B_Na_normal); // microS
        const NekDouble var_background_currents__i_B_Na =
            var_background_currents__g_B_Na *
            (var_background_currents__V -
             var_background_currents__E_Na); // nanoA
        const NekDouble var_sodium_potassium_pump__Na_o =
            var_standard_ionic_concentrations__Na_o; // millimolar
        const NekDouble var_sodium_potassium_pump__sigma =
            (exp(var_sodium_potassium_pump__Na_o / 67.3) - 1.0) /
            7.0; // dimensionless
        const NekDouble var_sodium_potassium_pump__K_m_Na = 10.0; // millimolar
        const NekDouble var_sodium_potassium_pump__K_m_K  = 1.5;  // millimolar
        const NekDouble var_sodium_potassium_pump__V =
            var_chaste_interface__membrane__V; // millivolt
        const NekDouble var_sodium_potassium_pump__T =
            var_membrane__T; // kelvin
        const NekDouble var_sodium_potassium_pump__R =
            var_membrane__R; // millijoule_per_mole_kelvin
        const NekDouble var_sodium_potassium_pump__Na_i =
            var_chaste_interface__intracellular_ion_concentrations__Na_i; // millimolar
        const NekDouble var_sodium_potassium_pump__F =
            var_membrane__F; // coulomb_per_mole
        const NekDouble var_sodium_potassium_pump__i_NaK_max_normal =
            0.08; // nanoA
        const NekDouble var_sodium_potassium_pump__Diabetes =
            var_membrane__Diabetes; // dimensionless
        const NekDouble var_sodium_potassium_pump__i_NaK_max =
            (var_sodium_potassium_pump__Diabetes == 0.0)
                ? var_sodium_potassium_pump__i_NaK_max_normal
                : (0.63 * var_sodium_potassium_pump__i_NaK_max_normal); // nanoA
        const NekDouble var_sodium_potassium_pump__K_o =
            var_standard_ionic_concentrations__K_o; // millimolar
        const NekDouble var_sodium_potassium_pump__i_NaK =
            (((var_sodium_potassium_pump__i_NaK_max /
               (1.0 +
                (0.1245 * exp(((-0.1) * var_sodium_potassium_pump__V *
                               var_sodium_potassium_pump__F) /
                              (var_sodium_potassium_pump__R *
                               var_sodium_potassium_pump__T))) +
                (0.0365 * var_sodium_potassium_pump__sigma *
                 exp(((-var_sodium_potassium_pump__V) *
                      var_sodium_potassium_pump__F) /
                     (var_sodium_potassium_pump__R *
                      var_sodium_potassium_pump__T))))) *
              var_sodium_potassium_pump__K_o) /
             (var_sodium_potassium_pump__K_o +
              var_sodium_potassium_pump__K_m_K)) /
            (1.0 + pow(var_sodium_potassium_pump__K_m_Na /
                           var_sodium_potassium_pump__Na_i,
                       1.5)); // nanoA
        const NekDouble var_Na_Ca_ion_exchanger_current__Na_o =
            var_standard_ionic_concentrations__Na_o; // millimolar
        const NekDouble var_Na_Ca_ion_exchanger_current__Na_i =
            var_chaste_interface__intracellular_ion_concentrations__Na_i; // millimolar
        const NekDouble var_Na_Ca_ion_exchanger_current__gamma_NaCa =
            0.5; // dimensionless
        const NekDouble var_Na_Ca_ion_exchanger_current__Ca_i =
            var_chaste_interface__intracellular_ion_concentrations__Ca_i; // millimolar
        const NekDouble var_Na_Ca_ion_exchanger_current__Ca_o =
            var_standard_ionic_concentrations__Ca_o; // millimolar
        const NekDouble var_Na_Ca_ion_exchanger_current__K_NaCa =
            9.984e-06; // nanoA_millimolar_4
        const NekDouble var_Na_Ca_ion_exchanger_current__d_NaCa =
            0.0001; // millimolar_4
        const NekDouble var_Na_Ca_ion_exchanger_current__V =
            var_chaste_interface__membrane__V; // millivolt
        const NekDouble var_Na_Ca_ion_exchanger_current__i_NaCa =
            (var_Na_Ca_ion_exchanger_current__K_NaCa *
             ((pow(var_Na_Ca_ion_exchanger_current__Na_i, 3.0) *
               var_Na_Ca_ion_exchanger_current__Ca_o *
               exp(0.03743 * var_Na_Ca_ion_exchanger_current__V *
                   var_Na_Ca_ion_exchanger_current__gamma_NaCa)) -
              (pow(var_Na_Ca_ion_exchanger_current__Na_o, 3.0) *
               var_Na_Ca_ion_exchanger_current__Ca_i *
               exp(0.03743 * var_Na_Ca_ion_exchanger_current__V *
                   (var_Na_Ca_ion_exchanger_current__gamma_NaCa - 1.0))))) /
            (1.0 +
             (var_Na_Ca_ion_exchanger_current__d_NaCa *
              ((var_Na_Ca_ion_exchanger_current__Ca_i *
                pow(var_Na_Ca_ion_exchanger_current__Na_o, 3.0)) +
               (var_Na_Ca_ion_exchanger_current__Ca_o *
                pow(var_Na_Ca_ion_exchanger_current__Na_i, 3.0))))); // nanoA
        const NekDouble var_sarcolemmal_calcium_pump_current__Ca_i =
            var_chaste_interface__intracellular_ion_concentrations__Ca_i; // millimolar
        const NekDouble var_sarcolemmal_calcium_pump_current__i_Ca_P_max =
            0.004; // nanoA
        const NekDouble var_sarcolemmal_calcium_pump_current__i_Ca_P =
            (var_sarcolemmal_calcium_pump_current__i_Ca_P_max *
             var_sarcolemmal_calcium_pump_current__Ca_i) /
            (var_sarcolemmal_calcium_pump_current__Ca_i + 0.0004); // nanoA
        const NekDouble var_sodium_current_m_gate__V =
            var_sodium_current__V; // millivolt
        const NekDouble var_sodium_current_m_gate__m_infinity =
            1.0 / (1.0 + exp((var_sodium_current_m_gate__V + 45.0) /
                             (-6.5))); // dimensionless
        const NekDouble var_sodium_current_m_gate__tau_m =
            0.00136 /
            (((0.32 * (var_sodium_current_m_gate__V + 47.13)) /
              (1.0 - exp((-0.1) * (var_sodium_current_m_gate__V + 47.13)))) +
             (0.08 * exp((-var_sodium_current_m_gate__V) / 11.0))); // second
        const NekDouble var_sodium_current_m_gate__m =
            var_sodium_current__m; // dimensionless
        const NekDouble var_sodium_current_m_gate__d_m_d_environment__time =
            (var_sodium_current_m_gate__m_infinity -
             var_sodium_current_m_gate__m) /
            var_sodium_current_m_gate__tau_m; // per_second
        const NekDouble
            var_sodium_current__sodium_current_m_gate__d_m_d_environment__time =
                var_sodium_current_m_gate__d_m_d_environment__time; // per_second
        const NekDouble var_sodium_current_h_gate__V =
            var_sodium_current__V; // millivolt
        const NekDouble var_sodium_current_h_gate__h_infinity =
            1.0 / (1.0 + exp((var_sodium_current_h_gate__V + 76.1) /
                             6.07)); // dimensionless
        const NekDouble var_sodium_current_h_gate__h =
            var_sodium_current__h; // dimensionless
        const NekDouble var_sodium_current_h_gate__tau_h =
            (var_sodium_current_h_gate__V >= (-40.0))
                ? (0.0004537 *
                   (1.0 +
                    exp((-(var_sodium_current_h_gate__V + 10.66)) / 11.1)))
                : (0.00349 /
                   ((0.135 *
                     exp((-(var_sodium_current_h_gate__V + 80.0)) / 6.8)) +
                    (3.56 * exp(0.079 * var_sodium_current_h_gate__V)) +
                    (310000.0 *
                     exp(0.35 * var_sodium_current_h_gate__V)))); // second
        const NekDouble var_sodium_current_h_gate__d_h_d_environment__time =
            (var_sodium_current_h_gate__h_infinity -
             var_sodium_current_h_gate__h) /
            var_sodium_current_h_gate__tau_h; // per_second
        const NekDouble
            var_sodium_current__sodium_current_h_gate__d_h_d_environment__time =
                var_sodium_current_h_gate__d_h_d_environment__time; // per_second
        const NekDouble var_sodium_current_j_gate__V =
            var_sodium_current__V; // millivolt
        const NekDouble var_sodium_current_j_gate__j_infinity =
            1.0 / (1.0 + exp((var_sodium_current_j_gate__V + 76.1) /
                             6.07)); // dimensionless
        const NekDouble var_sodium_current_j_gate__j =
            var_sodium_current__j; // dimensionless
        const NekDouble var_sodium_current_j_gate__tau_j =
            (var_sodium_current_j_gate__V >= (-40.0))
                ? ((0.01163 *
                    (1.0 +
                     exp((-0.1) * (var_sodium_current_j_gate__V + 32.0)))) /
                   exp((-2.535e-07) * var_sodium_current_j_gate__V))
                : (0.00349 /
                   ((((var_sodium_current_j_gate__V + 37.78) /
                      (1.0 +
                       exp(0.311 * (var_sodium_current_j_gate__V + 79.23)))) *
                     (((-127140.0) *
                       exp(0.2444 * var_sodium_current_j_gate__V)) -
                      (3.474e-05 *
                       exp((-0.04391) * var_sodium_current_j_gate__V)))) +
                    ((0.1212 * exp((-0.01052) * var_sodium_current_j_gate__V)) /
                     (1.0 + exp((-0.1378) * (var_sodium_current_j_gate__V +
                                             40.14)))))); // second
        const NekDouble var_sodium_current_j_gate__d_j_d_environment__time =
            (var_sodium_current_j_gate__j_infinity -
             var_sodium_current_j_gate__j) /
            var_sodium_current_j_gate__tau_j; // per_second
        const NekDouble
            var_sodium_current__sodium_current_j_gate__d_j_d_environment__time =
                var_sodium_current_j_gate__d_j_d_environment__time; // per_second
        const NekDouble var_L_type_Ca_channel__Ca_ss =
            var_chaste_interface__intracellular_ion_concentrations__Ca_ss; // millimolar
        const NekDouble var_L_type_Ca_channel_d_gate__d =
            var_L_type_Ca_channel__d; // dimensionless
        const NekDouble var_L_type_Ca_channel_d_gate__V =
            var_L_type_Ca_channel__V; // millivolt
        const NekDouble var_L_type_Ca_channel_d_gate__d_infinity =
            1.0 / (1.0 + exp((var_L_type_Ca_channel_d_gate__V + 15.3) /
                             (-5.0))); // dimensionless
        const NekDouble var_L_type_Ca_channel_d_gate__tau_d =
            (0.00305 *
             exp((-0.0045) * pow(var_L_type_Ca_channel_d_gate__V + 7.0, 2.0))) +
            (0.00105 *
             exp((-0.002) * pow(var_L_type_Ca_channel_d_gate__V - 18.0, 2.0))) +
            0.00025; // second
        const NekDouble var_L_type_Ca_channel_d_gate__d_d_d_environment__time =
            (var_L_type_Ca_channel_d_gate__d_infinity -
             var_L_type_Ca_channel_d_gate__d) /
            var_L_type_Ca_channel_d_gate__tau_d; // per_second
        const NekDouble
            var_L_type_Ca_channel__L_type_Ca_channel_d_gate__d_d_d_environment__time =
                var_L_type_Ca_channel_d_gate__d_d_d_environment__time; // per_second
        const NekDouble var_L_type_Ca_channel_f_11_gate__f_11 =
            var_L_type_Ca_channel__f_11; // dimensionless
        const NekDouble var_L_type_Ca_channel_f_11_gate__Diabetes =
            var_L_type_Ca_channel__Diabetes; // dimensionless
        const NekDouble var_L_type_Ca_channel_f_11_gate__V =
            var_L_type_Ca_channel__V; // millivolt
        const NekDouble var_L_type_Ca_channel_f_11_gate__tau_f_11 =
            (var_L_type_Ca_channel_f_11_gate__Diabetes == 0.0)
                ? ((0.105 *
                    exp(-pow((var_L_type_Ca_channel_f_11_gate__V + 45.0) / 12.0,
                             2.0))) +
                   (0.04 /
                    (1.0 + exp(((-var_L_type_Ca_channel_f_11_gate__V) + 25.0) /
                               25.0))) +
                   (0.015 /
                    (1.0 +
                     exp((var_L_type_Ca_channel_f_11_gate__V + 75.0) / 25.0))) +
                   0.0017)
                : ((0.9 * 0.105 *
                    exp(-pow((var_L_type_Ca_channel_f_11_gate__V + 45.0) / 12.0,
                             2.0))) +
                   (0.04 /
                    (1.0 + exp(((-var_L_type_Ca_channel_f_11_gate__V) + 25.0) /
                               25.0))) +
                   (0.015 /
                    (1.0 +
                     exp((var_L_type_Ca_channel_f_11_gate__V + 75.0) / 25.0))) +
                   0.0017); // second
        const NekDouble var_L_type_Ca_channel_f_11_gate__f_11_infinity =
            1.0 / (1.0 + exp((var_L_type_Ca_channel_f_11_gate__V + 26.7) /
                             5.4)); // dimensionless
        const NekDouble
            var_L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time =
                (var_L_type_Ca_channel_f_11_gate__f_11_infinity -
                 var_L_type_Ca_channel_f_11_gate__f_11) /
                var_L_type_Ca_channel_f_11_gate__tau_f_11; // per_second
        const NekDouble
            var_L_type_Ca_channel__L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time =
                var_L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time; // per_second
        const NekDouble var_L_type_Ca_channel_f_12_gate__f_12 =
            var_L_type_Ca_channel__f_12; // dimensionless
        const NekDouble var_L_type_Ca_channel_f_12_gate__V =
            var_L_type_Ca_channel__V; // millivolt
        const NekDouble var_L_type_Ca_channel_f_12_gate__f_12_infinity =
            1.0 / (1.0 + exp((var_L_type_Ca_channel_f_12_gate__V + 26.7) /
                             5.4)); // dimensionless
        const NekDouble var_L_type_Ca_channel_f_12_gate__tau_f_12 =
            (0.041 *
             exp(-pow((var_L_type_Ca_channel_f_12_gate__V + 47.0) / 12.0,
                      2.0))) +
            (0.08 / (1.0 + exp((var_L_type_Ca_channel_f_12_gate__V + 55.0) /
                               (-5.0)))) +
            (0.015 /
             (1.0 + exp((var_L_type_Ca_channel_f_12_gate__V + 75.0) / 25.0))) +
            0.0017; // second
        const NekDouble
            var_L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time =
                (var_L_type_Ca_channel_f_12_gate__f_12_infinity -
                 var_L_type_Ca_channel_f_12_gate__f_12) /
                var_L_type_Ca_channel_f_12_gate__tau_f_12; // per_second
        const NekDouble
            var_L_type_Ca_channel__L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time =
                var_L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time; // per_second
        const NekDouble var_L_type_Ca_channel_Ca_inact_gate__Ca_ss =
            var_L_type_Ca_channel__Ca_ss; // millimolar
        const NekDouble var_L_type_Ca_channel_Ca_inact_gate__Ca_inact_infinity =
            1.0 / (1.0 + (var_L_type_Ca_channel_Ca_inact_gate__Ca_ss /
                          0.01)); // dimensionless
        const NekDouble var_L_type_Ca_channel_Ca_inact_gate__tau_Ca_inact =
            0.009; // second
        const NekDouble var_L_type_Ca_channel_Ca_inact_gate__Ca_inact =
            var_L_type_Ca_channel__Ca_inact; // dimensionless
        const NekDouble
            var_L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time =
                (var_L_type_Ca_channel_Ca_inact_gate__Ca_inact_infinity -
                 var_L_type_Ca_channel_Ca_inact_gate__Ca_inact) /
                var_L_type_Ca_channel_Ca_inact_gate__tau_Ca_inact; // per_second
        const NekDouble
            var_L_type_Ca_channel__L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time =
                var_L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time; // per_second
        const NekDouble
            var_Ca_independent_transient_outward_K_current_r_gate__V =
                var_Ca_independent_transient_outward_K_current__V; // millivolt
        const NekDouble
            var_Ca_independent_transient_outward_K_current_r_gate__r_infinity =
                1.0 /
                (1.0 +
                 exp((var_Ca_independent_transient_outward_K_current_r_gate__V +
                      10.6) /
                     (-11.42))); // dimensionless
        const NekDouble var_Ca_independent_transient_outward_K_current_r_gate__r =
            var_Ca_independent_transient_outward_K_current__r; // dimensionless
        const NekDouble
            var_Ca_independent_transient_outward_K_current_r_gate__tau_r =
                1.0 /
                ((45.16 *
                  exp(0.03577 *
                      (var_Ca_independent_transient_outward_K_current_r_gate__V +
                       50.0))) +
                 (98.9 *
                  exp((-0.1) *
                      (var_Ca_independent_transient_outward_K_current_r_gate__V +
                       38.0)))); // second
        const NekDouble
            var_Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time =
                (var_Ca_independent_transient_outward_K_current_r_gate__r_infinity -
                 var_Ca_independent_transient_outward_K_current_r_gate__r) /
                var_Ca_independent_transient_outward_K_current_r_gate__tau_r; // per_second
        const NekDouble
            var_Ca_independent_transient_outward_K_current__Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time =
                var_Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time; // per_second
        const NekDouble
            var_Ca_independent_transient_outward_K_current_s_gate__V =
                var_Ca_independent_transient_outward_K_current__V; // millivolt
        const NekDouble
            var_Ca_independent_transient_outward_K_current_s_gate__s_infinity =
                1.0 /
                (1.0 +
                 exp((var_Ca_independent_transient_outward_K_current_s_gate__V +
                      45.3) /
                     6.8841)); // dimensionless
        const NekDouble
            var_Ca_independent_transient_outward_K_current_s_gate__tau_s =
                (0.35 *
                 exp(-pow(
                     (var_Ca_independent_transient_outward_K_current_s_gate__V +
                      70.0) /
                         15.0,
                     2.0))) +
                0.035; // second
        const NekDouble var_Ca_independent_transient_outward_K_current_s_gate__s =
            var_Ca_independent_transient_outward_K_current__s; // dimensionless
        const NekDouble
            var_Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time =
                (var_Ca_independent_transient_outward_K_current_s_gate__s_infinity -
                 var_Ca_independent_transient_outward_K_current_s_gate__s) /
                var_Ca_independent_transient_outward_K_current_s_gate__tau_s; // per_second
        const NekDouble
            var_Ca_independent_transient_outward_K_current__Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time =
                var_Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time; // per_second
        const NekDouble
            var_Ca_independent_transient_outward_K_current_s_slow_gate__V =
                var_Ca_independent_transient_outward_K_current__V; // millivolt
        const NekDouble
            var_Ca_independent_transient_outward_K_current_s_slow_gate__s_slow_infinity =
                1.0 /
                (1.0 +
                 exp((var_Ca_independent_transient_outward_K_current_s_slow_gate__V +
                      45.3) /
                     6.8841)); // dimensionless
        const NekDouble
            var_Ca_independent_transient_outward_K_current_s_slow_gate__s_slow =
                var_Ca_independent_transient_outward_K_current__s_slow; // dimensionless
        const NekDouble
            var_Ca_independent_transient_outward_K_current_s_slow_gate__tau_s_slow =
                (3.7 *
                 exp(-pow(
                     (var_Ca_independent_transient_outward_K_current_s_slow_gate__V +
                      70.0) /
                         30.0,
                     2.0))) +
                0.035; // second
        const NekDouble var_Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time =
            (var_Ca_independent_transient_outward_K_current_s_slow_gate__s_slow_infinity -
             var_Ca_independent_transient_outward_K_current_s_slow_gate__s_slow) /
            var_Ca_independent_transient_outward_K_current_s_slow_gate__tau_s_slow; // per_second
        const NekDouble
            var_Ca_independent_transient_outward_K_current__Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time =
                var_Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time; // per_second
        const NekDouble var_steady_state_outward_K_current_r_ss_gate__V =
            var_steady_state_outward_K_current__V; // millivolt
        const NekDouble
            var_steady_state_outward_K_current_r_ss_gate__r_ss_infinity =
                1.0 /
                (1.0 +
                 exp((var_steady_state_outward_K_current_r_ss_gate__V + 11.5) /
                     (-11.82))); // dimensionless
        const NekDouble var_steady_state_outward_K_current_r_ss_gate__r_ss =
            var_steady_state_outward_K_current__r_ss; // dimensionless
        const NekDouble var_steady_state_outward_K_current_r_ss_gate__tau_r_ss =
            10.0 /
            ((45.16 *
              exp(0.03577 *
                  (var_steady_state_outward_K_current_r_ss_gate__V + 50.0))) +
             (98.9 *
              exp((-0.1) * (var_steady_state_outward_K_current_r_ss_gate__V +
                            38.0)))); // second
        const NekDouble
            var_steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time =
                (var_steady_state_outward_K_current_r_ss_gate__r_ss_infinity -
                 var_steady_state_outward_K_current_r_ss_gate__r_ss) /
                var_steady_state_outward_K_current_r_ss_gate__tau_r_ss; // per_second
        const NekDouble
            var_steady_state_outward_K_current__steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time =
                var_steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time; // per_second
        const NekDouble var_steady_state_outward_K_current_s_ss_gate__s_ss =
            var_steady_state_outward_K_current__s_ss; // dimensionless
        const NekDouble var_steady_state_outward_K_current_s_ss_gate__tau_s_ss =
            2.1; // second
        const NekDouble var_steady_state_outward_K_current_s_ss_gate__V =
            var_steady_state_outward_K_current__V; // millivolt
        const NekDouble
            var_steady_state_outward_K_current_s_ss_gate__s_ss_infinity =
                1.0 /
                (1.0 +
                 exp((var_steady_state_outward_K_current_s_ss_gate__V + 87.5) /
                     10.3)); // dimensionless
        const NekDouble
            var_steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time =
                (var_steady_state_outward_K_current_s_ss_gate__s_ss_infinity -
                 var_steady_state_outward_K_current_s_ss_gate__s_ss) /
                var_steady_state_outward_K_current_s_ss_gate__tau_s_ss; // per_second
        const NekDouble
            var_steady_state_outward_K_current__steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time =
                var_steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time; // per_second
        const NekDouble var_hyperpolarisation_activated_current_y_gate__V =
            var_hyperpolarisation_activated_current__V; // millivolt
        const NekDouble var_hyperpolarisation_activated_current_y_gate__tau_y =
            1.0 /
            ((0.11885 *
              exp((var_hyperpolarisation_activated_current_y_gate__V + 80.0) /
                  28.37)) +
             (0.5623 *
              exp((var_hyperpolarisation_activated_current_y_gate__V + 80.0) /
                  (-14.19)))); // second
        const NekDouble var_hyperpolarisation_activated_current_y_gate__y =
            var_hyperpolarisation_activated_current__y; // dimensionless
        const NekDouble
            var_hyperpolarisation_activated_current_y_gate__y_infinity =
                1.0 /
                (1.0 + exp((var_hyperpolarisation_activated_current_y_gate__V +
                            138.6) /
                           10.48)); // dimensionless
        const NekDouble
            var_hyperpolarisation_activated_current_y_gate__d_y_d_environment__time =
                (var_hyperpolarisation_activated_current_y_gate__y_infinity -
                 var_hyperpolarisation_activated_current_y_gate__y) /
                var_hyperpolarisation_activated_current_y_gate__tau_y; // per_second
        const NekDouble
            var_hyperpolarisation_activated_current__hyperpolarisation_activated_current_y_gate__d_y_d_environment__time =
                var_hyperpolarisation_activated_current_y_gate__d_y_d_environment__time; // per_second
        const NekDouble var_SR_Ca_release_channel__Ca_ss =
            var_chaste_interface__intracellular_ion_concentrations__Ca_ss; // millimolar
        const NekDouble var_SR_Ca_release_channel__v1 = 1800.0; // per_second
        const NekDouble var_SR_Ca_release_channel__P_O2 =
            var_chaste_interface__SR_Ca_release_channel__P_O2; // dimensionless
        const NekDouble var_SR_Ca_release_channel__P_O1 =
            var_chaste_interface__SR_Ca_release_channel__P_O1; // dimensionless
        const NekDouble var_SR_Ca_release_channel__Ca_JSR =
            var_chaste_interface__intracellular_ion_concentrations__Ca_JSR; // millimolar
        const NekDouble var_SR_Ca_release_channel__J_rel =
            var_SR_Ca_release_channel__v1 *
            (var_SR_Ca_release_channel__P_O1 +
             var_SR_Ca_release_channel__P_O2) *
            (var_SR_Ca_release_channel__Ca_JSR -
             var_SR_Ca_release_channel__Ca_ss); // millimolar_per_second
        const NekDouble var_SR_Ca_release_channel__k_a_plus =
            1.215e+13; // per_second
        const NekDouble var_SR_Ca_release_channel__k_a_minus =
            576.0; // per_second
        const NekDouble var_SR_Ca_release_channel__k_b_plus =
            4050000000.0; // per_second
        const NekDouble var_SR_Ca_release_channel__k_b_minus =
            1930.0; // per_second
        const NekDouble var_SR_Ca_release_channel__k_c_plus =
            100.0; // per_second
        const NekDouble var_SR_Ca_release_channel__k_c_minus =
            0.8; // per_second
        const NekDouble var_SR_Ca_release_channel__P_C1 =
            var_chaste_interface__SR_Ca_release_channel__P_C1; // dimensionless
        const NekDouble var_SR_Ca_release_channel__P_C2 =
            var_chaste_interface__SR_Ca_release_channel__P_C2; // dimensionless
        const NekDouble var_SR_Ca_release_channel__n = 4.0;    // dimensionless
        const NekDouble var_SR_Ca_release_channel__m = 3.0;    // dimensionless
        const NekDouble var_SR_Ca_release_channel__d_P_O1_d_environment__time =
            ((var_SR_Ca_release_channel__k_a_plus *
              pow(var_SR_Ca_release_channel__Ca_ss / 1.0,
                  var_SR_Ca_release_channel__n) *
              var_SR_Ca_release_channel__P_C1) -
             ((var_SR_Ca_release_channel__k_a_minus *
               var_SR_Ca_release_channel__P_O1) +
              (var_SR_Ca_release_channel__k_b_plus *
               pow(var_SR_Ca_release_channel__Ca_ss / 1.0,
                   var_SR_Ca_release_channel__m) *
               var_SR_Ca_release_channel__P_O1) +
              (var_SR_Ca_release_channel__k_c_plus *
               var_SR_Ca_release_channel__P_O1))) +
            (var_SR_Ca_release_channel__k_b_minus *
             var_SR_Ca_release_channel__P_O2) +
            (var_SR_Ca_release_channel__k_c_minus *
             var_SR_Ca_release_channel__P_C2); // per_second
        const NekDouble var_SR_Ca_release_channel__d_P_O2_d_environment__time =
            (var_SR_Ca_release_channel__k_b_plus *
             pow(var_SR_Ca_release_channel__Ca_ss / 1.0,
                 var_SR_Ca_release_channel__m) *
             var_SR_Ca_release_channel__P_O1) -
            (var_SR_Ca_release_channel__k_b_minus *
             var_SR_Ca_release_channel__P_O2); // per_second
        const NekDouble var_SR_Ca_release_channel__d_P_C1_d_environment__time =
            ((-var_SR_Ca_release_channel__k_a_plus) *
             pow(var_SR_Ca_release_channel__Ca_ss / 1.0,
                 var_SR_Ca_release_channel__n) *
             var_SR_Ca_release_channel__P_C1) +
            (var_SR_Ca_release_channel__k_a_minus *
             var_SR_Ca_release_channel__P_O1); // per_second
        const NekDouble var_SR_Ca_release_channel__d_P_C2_d_environment__time =
            (var_SR_Ca_release_channel__k_c_plus *
             var_SR_Ca_release_channel__P_O1) -
            (var_SR_Ca_release_channel__k_c_minus *
             var_SR_Ca_release_channel__P_C2);             // per_second
        const NekDouble var_SERCA2a_pump__N_fb = 1.2;      // dimensionless
        const NekDouble var_SERCA2a_pump__K_fb = 0.000168; // millimolar
        const NekDouble var_SERCA2a_pump__Ca_i =
            var_chaste_interface__intracellular_ion_concentrations__Ca_i; // millimolar
        const NekDouble var_SERCA2a_pump__fb =
            pow(var_SERCA2a_pump__Ca_i / var_SERCA2a_pump__K_fb,
                var_SERCA2a_pump__N_fb); // dimensionless
        const NekDouble var_SERCA2a_pump__Diabetes =
            var_membrane__Diabetes; // dimensionless
        const NekDouble var_SERCA2a_pump__Vmaxf_normal =
            0.04; // millimolar_per_second
        const NekDouble var_SERCA2a_pump__Vmaxf =
            (var_SERCA2a_pump__Diabetes == 0.0)
                ? var_SERCA2a_pump__Vmaxf_normal
                : (0.8 *
                   var_SERCA2a_pump__Vmaxf_normal); // millimolar_per_second
        const NekDouble var_SERCA2a_pump__K_SR_normal = 1.0; // dimensionless
        const NekDouble var_SERCA2a_pump__K_SR =
            (var_SERCA2a_pump__Diabetes == 0.0)
                ? var_SERCA2a_pump__K_SR_normal
                : (0.55 * var_SERCA2a_pump__K_SR_normal); // dimensionless
        const NekDouble var_SERCA2a_pump__Ca_NSR =
            var_chaste_interface__intracellular_ion_concentrations__Ca_NSR; // millimolar
        const NekDouble var_SERCA2a_pump__K_rb = 3.29; // millimolar
        const NekDouble var_SERCA2a_pump__N_rb = 1.0;  // dimensionless
        const NekDouble var_SERCA2a_pump__rb =
            pow(var_SERCA2a_pump__Ca_NSR / var_SERCA2a_pump__K_rb,
                var_SERCA2a_pump__N_rb);               // dimensionless
        const NekDouble var_SERCA2a_pump__Vmaxr = 0.9; // millimolar_per_second
        const NekDouble var_SERCA2a_pump__J_up =
            (var_SERCA2a_pump__K_SR *
             ((var_SERCA2a_pump__Vmaxf * var_SERCA2a_pump__fb) -
              (var_SERCA2a_pump__Vmaxr * var_SERCA2a_pump__rb))) /
            (1.0 + var_SERCA2a_pump__fb +
             var_SERCA2a_pump__rb); // millimolar_per_second
        const NekDouble var_intracellular_and_SR_Ca_fluxes__tau_tr =
            0.0005747; // second
        const NekDouble var_intracellular_and_SR_Ca_fluxes__Ca_JSR =
            var_chaste_interface__intracellular_ion_concentrations__Ca_JSR; // millimolar
        const NekDouble var_intracellular_and_SR_Ca_fluxes__Ca_NSR =
            var_chaste_interface__intracellular_ion_concentrations__Ca_NSR; // millimolar
        const NekDouble var_intracellular_and_SR_Ca_fluxes__J_tr =
            (var_intracellular_and_SR_Ca_fluxes__Ca_NSR -
             var_intracellular_and_SR_Ca_fluxes__Ca_JSR) /
            var_intracellular_and_SR_Ca_fluxes__tau_tr; // millimolar_per_second
        const NekDouble var_intracellular_and_SR_Ca_fluxes__Ca_ss =
            var_chaste_interface__intracellular_ion_concentrations__Ca_ss; // millimolar
        const NekDouble var_intracellular_and_SR_Ca_fluxes__Ca_i =
            var_chaste_interface__intracellular_ion_concentrations__Ca_i; // millimolar
        const NekDouble var_intracellular_and_SR_Ca_fluxes__tau_xfer =
            0.0267; // second
        const NekDouble var_intracellular_and_SR_Ca_fluxes__J_xfer =
            (var_intracellular_and_SR_Ca_fluxes__Ca_ss -
             var_intracellular_and_SR_Ca_fluxes__Ca_i) /
            var_intracellular_and_SR_Ca_fluxes__tau_xfer; // millimolar_per_second
        const NekDouble var_intracellular_and_SR_Ca_fluxes__k_htrpn_plus =
            200000.0; // per_millimolar_per_second
        const NekDouble var_intracellular_and_SR_Ca_fluxes__k_htrpn_minus =
            0.066; // per_second
        const NekDouble var_intracellular_and_SR_Ca_fluxes__HTRPNCa =
            var_chaste_interface__intracellular_and_SR_Ca_fluxes__HTRPNCa; // millimolar
        const NekDouble var_intracellular_and_SR_Ca_fluxes__HTRPN_tot =
            0.14; // millimolar
        const NekDouble var_intracellular_and_SR_Ca_fluxes__J_HTRPNCa =
            (var_intracellular_and_SR_Ca_fluxes__k_htrpn_plus *
             var_intracellular_and_SR_Ca_fluxes__Ca_i *
             (var_intracellular_and_SR_Ca_fluxes__HTRPN_tot -
              var_intracellular_and_SR_Ca_fluxes__HTRPNCa)) -
            (var_intracellular_and_SR_Ca_fluxes__k_htrpn_minus *
             var_intracellular_and_SR_Ca_fluxes__HTRPNCa); // millimolar_per_second
        const NekDouble var_intracellular_and_SR_Ca_fluxes__LTRPNCa =
            var_chaste_interface__intracellular_and_SR_Ca_fluxes__LTRPNCa; // millimolar
        const NekDouble var_intracellular_and_SR_Ca_fluxes__LTRPN_tot =
            0.07; // millimolar
        const NekDouble var_intracellular_and_SR_Ca_fluxes__k_ltrpn_plus =
            40000.0; // per_millimolar_per_second
        const NekDouble var_intracellular_and_SR_Ca_fluxes__k_ltrpn_minus =
            40.0; // per_second
        const NekDouble var_intracellular_and_SR_Ca_fluxes__J_LTRPNCa =
            (var_intracellular_and_SR_Ca_fluxes__k_ltrpn_plus *
             var_intracellular_and_SR_Ca_fluxes__Ca_i *
             (var_intracellular_and_SR_Ca_fluxes__LTRPN_tot -
              var_intracellular_and_SR_Ca_fluxes__LTRPNCa)) -
            (var_intracellular_and_SR_Ca_fluxes__k_ltrpn_minus *
             var_intracellular_and_SR_Ca_fluxes__LTRPNCa); // millimolar_per_second
        const NekDouble var_intracellular_and_SR_Ca_fluxes__J_trpn =
            var_intracellular_and_SR_Ca_fluxes__J_HTRPNCa +
            var_intracellular_and_SR_Ca_fluxes__J_LTRPNCa; // millimolar_per_second
        const NekDouble
            var_intracellular_and_SR_Ca_fluxes__d_HTRPNCa_d_environment__time =
                (var_intracellular_and_SR_Ca_fluxes__k_htrpn_plus *
                 var_intracellular_and_SR_Ca_fluxes__Ca_i *
                 (var_intracellular_and_SR_Ca_fluxes__HTRPN_tot -
                  var_intracellular_and_SR_Ca_fluxes__HTRPNCa)) -
                (var_intracellular_and_SR_Ca_fluxes__k_htrpn_minus *
                 var_intracellular_and_SR_Ca_fluxes__HTRPNCa); // 'millimole per
                                                               // litre per
                                                               // second'
        const NekDouble
            var_intracellular_and_SR_Ca_fluxes__d_LTRPNCa_d_environment__time =
                (var_intracellular_and_SR_Ca_fluxes__k_ltrpn_plus *
                 var_intracellular_and_SR_Ca_fluxes__Ca_i *
                 (var_intracellular_and_SR_Ca_fluxes__LTRPN_tot -
                  var_intracellular_and_SR_Ca_fluxes__LTRPNCa)) -
                (var_intracellular_and_SR_Ca_fluxes__k_ltrpn_minus *
                 var_intracellular_and_SR_Ca_fluxes__LTRPNCa); // 'millimole per
                                                               // litre per
                                                               // second'
        const NekDouble var_intracellular_ion_concentrations__Ca_i =
            var_chaste_interface__intracellular_ion_concentrations__Ca_i; // millimolar
        const NekDouble var_intracellular_ion_concentrations__Ca_ss =
            var_chaste_interface__intracellular_ion_concentrations__Ca_ss; // millimolar
        const NekDouble var_intracellular_ion_concentrations__Ca_JSR =
            var_chaste_interface__intracellular_ion_concentrations__Ca_JSR; // millimolar
        const NekDouble var_intracellular_ion_concentrations__V_myo =
            9.36e-06; // micro_litre
        const NekDouble var_intracellular_ion_concentrations__V_JSR =
            5.6e-07; // micro_litre
        const NekDouble var_intracellular_ion_concentrations__V_NSR =
            5.04e-06; // micro_litre
        const NekDouble var_intracellular_ion_concentrations__V_SS =
            1.2e-08; // micro_litre
        const NekDouble var_intracellular_ion_concentrations__K_mCMDN =
            0.00238; // millimolar
        const NekDouble var_intracellular_ion_concentrations__K_mCSQN =
            0.8; // millimolar
        const NekDouble var_intracellular_ion_concentrations__K_mEGTA =
            0.00015; // millimolar
        const NekDouble var_intracellular_ion_concentrations__CMDN_tot =
            0.05; // millimolar
        const NekDouble var_intracellular_ion_concentrations__CSQN_tot =
            15.0; // millimolar
        const NekDouble var_intracellular_ion_concentrations__EGTA_tot =
            10.0; // millimolar
        const NekDouble var_intracellular_ion_concentrations__beta_i =
            1.0 / (1.0 +
                   ((var_intracellular_ion_concentrations__CMDN_tot *
                     var_intracellular_ion_concentrations__K_mCMDN) /
                    pow(var_intracellular_ion_concentrations__K_mCMDN +
                            var_intracellular_ion_concentrations__Ca_i,
                        2.0)) +
                   ((var_intracellular_ion_concentrations__EGTA_tot *
                     var_intracellular_ion_concentrations__K_mEGTA) /
                    pow(var_intracellular_ion_concentrations__K_mEGTA +
                            var_intracellular_ion_concentrations__Ca_i,
                        2.0))); // dimensionless
        const NekDouble var_intracellular_ion_concentrations__beta_SS =
            1.0 / (1.0 + ((var_intracellular_ion_concentrations__CMDN_tot *
                           var_intracellular_ion_concentrations__K_mCMDN) /
                          pow(var_intracellular_ion_concentrations__K_mCMDN +
                                  var_intracellular_ion_concentrations__Ca_ss,
                              2.0))); // dimensionless
        const NekDouble var_intracellular_ion_concentrations__beta_JSR =
            1.0 / (1.0 + ((var_intracellular_ion_concentrations__CSQN_tot *
                           var_intracellular_ion_concentrations__K_mCSQN) /
                          pow(var_intracellular_ion_concentrations__K_mCSQN +
                                  var_intracellular_ion_concentrations__Ca_JSR,
                              2.0))); // dimensionless
        const NekDouble var_intracellular_ion_concentrations__F =
            var_membrane__F; // coulomb_per_mole
        const NekDouble var_intracellular_ion_concentrations__i_Na =
            var_sodium_current__i_Na; // nanoA
        const NekDouble var_intracellular_ion_concentrations__i_Ca_L =
            var_L_type_Ca_channel__i_Ca_L; // nanoA
        const NekDouble var_intracellular_ion_concentrations__i_B_Na =
            var_background_currents__i_B_Na; // nanoA
        const NekDouble var_intracellular_ion_concentrations__i_NaCa =
            var_Na_Ca_ion_exchanger_current__i_NaCa; // nanoA
        const NekDouble var_intracellular_ion_concentrations__i_NaK =
            var_sodium_potassium_pump__i_NaK; // nanoA
        const NekDouble var_intracellular_ion_concentrations__i_f_Na =
            var_hyperpolarisation_activated_current__i_f_Na; // nanoA
        const NekDouble var_intracellular_ion_concentrations__i_f_K =
            var_hyperpolarisation_activated_current__i_f_K; // nanoA
        const NekDouble var_intracellular_ion_concentrations__i_B_K =
            var_background_currents__i_B_K; // nanoA
        const NekDouble var_intracellular_ion_concentrations__i_K1 =
            var_inward_rectifier__i_K1; // nanoA
        const NekDouble var_intracellular_ion_concentrations__i_t =
            var_Ca_independent_transient_outward_K_current__i_t; // nanoA
        const NekDouble var_intracellular_ion_concentrations__i_ss =
            var_steady_state_outward_K_current__i_ss; // nanoA
        const NekDouble var_intracellular_ion_concentrations__i_Ca_P =
            var_sarcolemmal_calcium_pump_current__i_Ca_P; // nanoA
        const NekDouble var_intracellular_ion_concentrations__i_B_Ca =
            var_background_currents__i_B_Ca; // nanoA
        const NekDouble var_intracellular_ion_concentrations__J_up =
            var_SERCA2a_pump__J_up; // millimolar_per_second
        const NekDouble var_intracellular_ion_concentrations__J_rel =
            var_SR_Ca_release_channel__J_rel; // millimolar_per_second
        const NekDouble var_intracellular_ion_concentrations__J_xfer =
            var_intracellular_and_SR_Ca_fluxes__J_xfer; // millimolar_per_second
        const NekDouble var_intracellular_ion_concentrations__J_trpn =
            var_intracellular_and_SR_Ca_fluxes__J_trpn; // millimolar_per_second
        const NekDouble var_intracellular_ion_concentrations__J_tr =
            var_intracellular_and_SR_Ca_fluxes__J_tr; // millimolar_per_second
        const NekDouble
            var_intracellular_ion_concentrations__d_Na_i_d_environment__time =
                (-(var_intracellular_ion_concentrations__i_Na +
                   var_intracellular_ion_concentrations__i_B_Na +
                   (var_intracellular_ion_concentrations__i_NaCa * 3.0) +
                   (var_intracellular_ion_concentrations__i_NaK * 3.0) +
                   var_intracellular_ion_concentrations__i_f_Na)) /
                (var_intracellular_ion_concentrations__V_myo *
                 var_intracellular_ion_concentrations__F); // 'millimole per
                                                           // litre per second'
        const NekDouble
            var_intracellular_ion_concentrations__d_Ca_i_d_environment__time =
                var_intracellular_ion_concentrations__beta_i *
                (var_intracellular_ion_concentrations__J_xfer -
                 (var_intracellular_ion_concentrations__J_up +
                  var_intracellular_ion_concentrations__J_trpn +
                  (((var_intracellular_ion_concentrations__i_B_Ca -
                     (2.0 * var_intracellular_ion_concentrations__i_NaCa)) +
                    var_intracellular_ion_concentrations__i_Ca_P) /
                   (2.0 * var_intracellular_ion_concentrations__V_myo *
                    var_intracellular_ion_concentrations__F)))); // 'millimole
                                                                 // per litre
                                                                 // per second'
        const NekDouble
            var_intracellular_ion_concentrations__d_K_i_d_environment__time =
                (-(var_intracellular_ion_concentrations__i_ss +
                   var_intracellular_ion_concentrations__i_B_K +
                   var_intracellular_ion_concentrations__i_t +
                   var_intracellular_ion_concentrations__i_K1 +
                   var_intracellular_ion_concentrations__i_f_K +
                   (var_intracellular_ion_concentrations__i_NaK * (-2.0)))) /
                (var_intracellular_ion_concentrations__V_myo *
                 var_intracellular_ion_concentrations__F); // 'millimole per
                                                           // litre per second'
        const NekDouble
            var_intracellular_ion_concentrations__d_Ca_ss_d_environment__time =
                var_intracellular_ion_concentrations__beta_SS *
                ((((var_intracellular_ion_concentrations__J_rel *
                    var_intracellular_ion_concentrations__V_JSR) /
                   var_intracellular_ion_concentrations__V_SS) -
                  ((var_intracellular_ion_concentrations__J_xfer *
                    var_intracellular_ion_concentrations__V_myo) /
                   var_intracellular_ion_concentrations__V_SS)) -
                 (var_intracellular_ion_concentrations__i_Ca_L /
                  (2.0 * var_intracellular_ion_concentrations__V_SS *
                   var_intracellular_ion_concentrations__F))); // 'millimole per
                                                               // litre per
                                                               // second'
        const NekDouble
            var_intracellular_ion_concentrations__d_Ca_JSR_d_environment__time =
                var_intracellular_ion_concentrations__beta_JSR *
                (var_intracellular_ion_concentrations__J_tr -
                 var_intracellular_ion_concentrations__J_rel); // 'millimole per
                                                               // litre per
                                                               // second'
        const NekDouble
            var_intracellular_ion_concentrations__d_Ca_NSR_d_environment__time =
                ((var_intracellular_ion_concentrations__J_up *
                  var_intracellular_ion_concentrations__V_myo) /
                 var_intracellular_ion_concentrations__V_NSR) -
                ((var_intracellular_ion_concentrations__J_tr *
                  var_intracellular_ion_concentrations__V_JSR) /
                 var_intracellular_ion_concentrations__V_NSR); // 'millimole per
                                                               // litre per
                                                               // second'
        const NekDouble
            var_chaste_interface__sodium_current_m_gate__d_m_d_environment__time_converter =
                var_sodium_current__sodium_current_m_gate__d_m_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__sodium_current_m_gate__d_m_d_environment__time =
                0.001 *
                var_chaste_interface__sodium_current_m_gate__d_m_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__sodium_current_h_gate__d_h_d_environment__time_converter =
                var_sodium_current__sodium_current_h_gate__d_h_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__sodium_current_h_gate__d_h_d_environment__time =
                0.001 *
                var_chaste_interface__sodium_current_h_gate__d_h_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__sodium_current_j_gate__d_j_d_environment__time_converter =
                var_sodium_current__sodium_current_j_gate__d_j_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__sodium_current_j_gate__d_j_d_environment__time =
                0.001 *
                var_chaste_interface__sodium_current_j_gate__d_j_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__L_type_Ca_channel_d_gate__d_d_d_environment__time_converter =
                var_L_type_Ca_channel__L_type_Ca_channel_d_gate__d_d_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__L_type_Ca_channel_d_gate__d_d_d_environment__time =
                0.001 *
                var_chaste_interface__L_type_Ca_channel_d_gate__d_d_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time_converter =
                var_L_type_Ca_channel__L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time =
                0.001 *
                var_chaste_interface__L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time_converter =
                var_L_type_Ca_channel__L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time =
                0.001 *
                var_chaste_interface__L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time_converter =
                var_L_type_Ca_channel__L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time =
                0.001 *
                var_chaste_interface__L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time_converter =
                var_Ca_independent_transient_outward_K_current__Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time =
                0.001 *
                var_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time_converter =
                var_Ca_independent_transient_outward_K_current__Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time =
                0.001 *
                var_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time_converter =
                var_Ca_independent_transient_outward_K_current__Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time =
                0.001 *
                var_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time_converter =
                var_steady_state_outward_K_current__steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time =
                0.001 *
                var_chaste_interface__steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time_converter =
                var_steady_state_outward_K_current__steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time =
                0.001 *
                var_chaste_interface__steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__hyperpolarisation_activated_current_y_gate__d_y_d_environment__time_converter =
                var_hyperpolarisation_activated_current__hyperpolarisation_activated_current_y_gate__d_y_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__hyperpolarisation_activated_current_y_gate__d_y_d_environment__time =
                0.001 *
                var_chaste_interface__hyperpolarisation_activated_current_y_gate__d_y_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__SR_Ca_release_channel__d_P_O1_d_environment__time_converter =
                var_SR_Ca_release_channel__d_P_O1_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__SR_Ca_release_channel__d_P_O1_d_environment__time =
                0.001 *
                var_chaste_interface__SR_Ca_release_channel__d_P_O1_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__SR_Ca_release_channel__d_P_O2_d_environment__time_converter =
                var_SR_Ca_release_channel__d_P_O2_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__SR_Ca_release_channel__d_P_O2_d_environment__time =
                0.001 *
                var_chaste_interface__SR_Ca_release_channel__d_P_O2_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__SR_Ca_release_channel__d_P_C1_d_environment__time_converter =
                var_SR_Ca_release_channel__d_P_C1_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__SR_Ca_release_channel__d_P_C1_d_environment__time =
                0.001 *
                var_chaste_interface__SR_Ca_release_channel__d_P_C1_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__SR_Ca_release_channel__d_P_C2_d_environment__time_converter =
                var_SR_Ca_release_channel__d_P_C2_d_environment__time; // per_second
        const NekDouble
            var_chaste_interface__SR_Ca_release_channel__d_P_C2_d_environment__time =
                0.001 *
                var_chaste_interface__SR_Ca_release_channel__d_P_C2_d_environment__time_converter; // 'per millisecond'
        const NekDouble
            var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_HTRPNCa_d_environment__time_converter =
                var_intracellular_and_SR_Ca_fluxes__d_HTRPNCa_d_environment__time; // ___units_26
        const NekDouble
            var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_HTRPNCa_d_environment__time =
                0.001 *
                var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_HTRPNCa_d_environment__time_converter; // 'millimolar per millisecond'
        const NekDouble
            var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_LTRPNCa_d_environment__time_converter =
                var_intracellular_and_SR_Ca_fluxes__d_LTRPNCa_d_environment__time; // millimole_per_litre_per_second
        const NekDouble
            var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_LTRPNCa_d_environment__time =
                0.001 *
                var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_LTRPNCa_d_environment__time_converter; // 'millimolar per millisecond'
        const NekDouble
            var_chaste_interface__intracellular_ion_concentrations__d_Na_i_d_environment__time_converter =
                var_intracellular_ion_concentrations__d_Na_i_d_environment__time; // millimole_per_litre_per_second
        const NekDouble
            var_chaste_interface__intracellular_ion_concentrations__d_Na_i_d_environment__time =
                0.001 *
                var_chaste_interface__intracellular_ion_concentrations__d_Na_i_d_environment__time_converter; // 'millimolar per millisecond'
        const NekDouble
            var_chaste_interface__intracellular_ion_concentrations__d_Ca_i_d_environment__time_converter =
                var_intracellular_ion_concentrations__d_Ca_i_d_environment__time; // millimole_per_litre_per_second
        const NekDouble
            var_chaste_interface__intracellular_ion_concentrations__d_Ca_i_d_environment__time =
                0.001 *
                var_chaste_interface__intracellular_ion_concentrations__d_Ca_i_d_environment__time_converter; // 'millimolar per millisecond'
        const NekDouble
            var_chaste_interface__intracellular_ion_concentrations__d_K_i_d_environment__time_converter =
                var_intracellular_ion_concentrations__d_K_i_d_environment__time; // millimole_per_litre_per_second
        const NekDouble
            var_chaste_interface__intracellular_ion_concentrations__d_K_i_d_environment__time =
                0.001 *
                var_chaste_interface__intracellular_ion_concentrations__d_K_i_d_environment__time_converter; // 'millimolar per millisecond'
        const NekDouble
            var_chaste_interface__intracellular_ion_concentrations__d_Ca_ss_d_environment__time_converter =
                var_intracellular_ion_concentrations__d_Ca_ss_d_environment__time; // millimole_per_litre_per_second
        const NekDouble
            var_chaste_interface__intracellular_ion_concentrations__d_Ca_ss_d_environment__time =
                0.001 *
                var_chaste_interface__intracellular_ion_concentrations__d_Ca_ss_d_environment__time_converter; // 'millimolar per millisecond'
        const NekDouble
            var_chaste_interface__intracellular_ion_concentrations__d_Ca_JSR_d_environment__time_converter =
                var_intracellular_ion_concentrations__d_Ca_JSR_d_environment__time; // millimole_per_litre_per_second
        const NekDouble
            var_chaste_interface__intracellular_ion_concentrations__d_Ca_JSR_d_environment__time =
                0.001 *
                var_chaste_interface__intracellular_ion_concentrations__d_Ca_JSR_d_environment__time_converter; // 'millimolar per millisecond'
        const NekDouble
            var_chaste_interface__intracellular_ion_concentrations__d_Ca_NSR_d_environment__time_converter =
                var_intracellular_ion_concentrations__d_Ca_NSR_d_environment__time; // millimole_per_litre_per_second
        const NekDouble
            var_chaste_interface__intracellular_ion_concentrations__d_Ca_NSR_d_environment__time =
                0.001 *
                var_chaste_interface__intracellular_ion_concentrations__d_Ca_NSR_d_environment__time_converter; // 'millimolar per millisecond'
        const NekDouble d_dt_chaste_interface__sodium_current_m_gate__m =
            var_chaste_interface__sodium_current_m_gate__d_m_d_environment__time; // 'per millisecond'
        const NekDouble d_dt_chaste_interface__sodium_current_h_gate__h =
            var_chaste_interface__sodium_current_h_gate__d_h_d_environment__time; // 'per millisecond'
        const NekDouble d_dt_chaste_interface__sodium_current_j_gate__j =
            var_chaste_interface__sodium_current_j_gate__d_j_d_environment__time; // 'per millisecond'
        const NekDouble d_dt_chaste_interface__L_type_Ca_channel_d_gate__d =
            var_chaste_interface__L_type_Ca_channel_d_gate__d_d_d_environment__time; // 'per millisecond'
        const NekDouble d_dt_chaste_interface__L_type_Ca_channel_f_11_gate__f_11 =
            var_chaste_interface__L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time; // 'per millisecond'
        const NekDouble d_dt_chaste_interface__L_type_Ca_channel_f_12_gate__f_12 =
            var_chaste_interface__L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time; // 'per millisecond'
        const NekDouble
            d_dt_chaste_interface__L_type_Ca_channel_Ca_inact_gate__Ca_inact =
                var_chaste_interface__L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time; // 'per millisecond'
        const NekDouble
            d_dt_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__r =
                var_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time; // 'per millisecond'
        const NekDouble
            d_dt_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__s =
                var_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time; // 'per millisecond'
        const NekDouble
            d_dt_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__s_slow =
                var_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time; // 'per millisecond'
        const NekDouble
            d_dt_chaste_interface__steady_state_outward_K_current_r_ss_gate__r_ss =
                var_chaste_interface__steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time; // 'per millisecond'
        const NekDouble
            d_dt_chaste_interface__steady_state_outward_K_current_s_ss_gate__s_ss =
                var_chaste_interface__steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time; // 'per millisecond'
        const NekDouble
            d_dt_chaste_interface__hyperpolarisation_activated_current_y_gate__y =
                var_chaste_interface__hyperpolarisation_activated_current_y_gate__d_y_d_environment__time; // 'per millisecond'
        const NekDouble d_dt_chaste_interface__SR_Ca_release_channel__P_O1 =
            var_chaste_interface__SR_Ca_release_channel__d_P_O1_d_environment__time; // 'per millisecond'
        const NekDouble d_dt_chaste_interface__SR_Ca_release_channel__P_O2 =
            var_chaste_interface__SR_Ca_release_channel__d_P_O2_d_environment__time; // 'per millisecond'
        const NekDouble d_dt_chaste_interface__SR_Ca_release_channel__P_C1 =
            var_chaste_interface__SR_Ca_release_channel__d_P_C1_d_environment__time; // 'per millisecond'
        const NekDouble d_dt_chaste_interface__SR_Ca_release_channel__P_C2 =
            var_chaste_interface__SR_Ca_release_channel__d_P_C2_d_environment__time; // 'per millisecond'
        const NekDouble
            d_dt_chaste_interface__intracellular_and_SR_Ca_fluxes__HTRPNCa =
                var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_HTRPNCa_d_environment__time; // 'millimole per litre per millisecond'
        const NekDouble
            d_dt_chaste_interface__intracellular_and_SR_Ca_fluxes__LTRPNCa =
                var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_LTRPNCa_d_environment__time; // 'millimole per litre per millisecond'
        const NekDouble d_dt_chaste_interface__intracellular_ion_concentrations__Na_i =
            var_chaste_interface__intracellular_ion_concentrations__d_Na_i_d_environment__time; // 'millimole per litre per millisecond'
        const NekDouble d_dt_chaste_interface__intracellular_ion_concentrations__Ca_i =
            var_chaste_interface__intracellular_ion_concentrations__d_Ca_i_d_environment__time; // 'millimole per litre per millisecond'
        const NekDouble d_dt_chaste_interface__intracellular_ion_concentrations__K_i =
            var_chaste_interface__intracellular_ion_concentrations__d_K_i_d_environment__time; // 'millimole per litre per millisecond'
        const NekDouble
            d_dt_chaste_interface__intracellular_ion_concentrations__Ca_ss =
                var_chaste_interface__intracellular_ion_concentrations__d_Ca_ss_d_environment__time; // 'millimole per litre per millisecond'
        const NekDouble
            d_dt_chaste_interface__intracellular_ion_concentrations__Ca_JSR =
                var_chaste_interface__intracellular_ion_concentrations__d_Ca_JSR_d_environment__time; // 'millimole per litre per millisecond'
        const NekDouble
            d_dt_chaste_interface__intracellular_ion_concentrations__Ca_NSR =
                var_chaste_interface__intracellular_ion_concentrations__d_Ca_NSR_d_environment__time; // 'millimole per litre per millisecond'
 
        const NekDouble var_membrane__Cm   = 0.0001;                   // microF
        const NekDouble var_membrane__i_Na = var_sodium_current__i_Na; // nanoA
        const NekDouble var_membrane__i_Ca_L =
            var_L_type_Ca_channel__i_Ca_L; // nanoA
        const NekDouble var_membrane__i_t =
            var_Ca_independent_transient_outward_K_current__i_t; // nanoA
        const NekDouble var_membrane__i_ss =
            var_steady_state_outward_K_current__i_ss; // nanoA
        const NekDouble var_hyperpolarisation_activated_current__i_f =
            var_hyperpolarisation_activated_current__i_f_Na +
            var_hyperpolarisation_activated_current__i_f_K; // nanoA
        const NekDouble var_membrane__i_f =
            var_hyperpolarisation_activated_current__i_f; // nanoA
        const NekDouble var_membrane__i_K1 =
            var_inward_rectifier__i_K1; // nanoA
        const NekDouble var_background_currents__i_B =
            var_background_currents__i_B_Na + var_background_currents__i_B_Ca +
            var_background_currents__i_B_K; // nanoA
        const NekDouble var_membrane__i_B =
            var_background_currents__i_B; // nanoA
        const NekDouble var_membrane__i_NaK =
            var_sodium_potassium_pump__i_NaK; // nanoA
        const NekDouble var_membrane__i_NaCa =
            var_Na_Ca_ion_exchanger_current__i_NaCa; // nanoA
        const NekDouble var_membrane__i_Ca_P =
            var_sarcolemmal_calcium_pump_current__i_Ca_P; // nanoA
        const NekDouble var_chaste_interface__membrane__i_Stim = 0.0;
        const NekDouble var_membrane__i_Stim_converter =
            var_chaste_interface__membrane__i_Stim; // uA_per_cm2
        const NekDouble
            var_membrane__chaste_interface__chaste_membrane_capacitance =
                1.0; // uF_per_cm2
        const NekDouble var_membrane__i_Stim =
            1000.0 *
            ((var_membrane__i_Stim_converter * var_membrane__Cm) /
             var_membrane__chaste_interface__chaste_membrane_capacitance); // nanoA
        const NekDouble var_membrane__d_V_d_environment__time =
            (-(var_membrane__i_Na + var_membrane__i_Ca_L + var_membrane__i_t +
               var_membrane__i_ss + var_membrane__i_f + var_membrane__i_K1 +
               var_membrane__i_B + var_membrane__i_NaK + var_membrane__i_NaCa +
               var_membrane__i_Ca_P + var_membrane__i_Stim)) /
            var_membrane__Cm; // 'millivolt per second'
        const NekDouble
            var_chaste_interface__membrane__d_V_d_environment__time_converter =
                var_membrane__d_V_d_environment__time; // ___units_1
        const NekDouble var_chaste_interface__membrane__d_V_d_environment__time =
            0.001 *
            var_chaste_interface__membrane__d_V_d_environment__time_converter; // 'millivolt per millisecond'
        d_dt_chaste_interface__membrane__V =
            var_chaste_interface__membrane__d_V_d_environment__time; // 'millivolt
                                                                     // per
                                                                     // millisecond'
        outarray[0][i] = d_dt_chaste_interface__membrane__V;
        outarray[1][i] = 0.0;
        outarray[2][i] = d_dt_chaste_interface__sodium_current_m_gate__m;
        outarray[3][i] = d_dt_chaste_interface__sodium_current_h_gate__h;
        outarray[4][i] = d_dt_chaste_interface__sodium_current_j_gate__j;
        outarray[5][i] = d_dt_chaste_interface__L_type_Ca_channel_d_gate__d;
        outarray[6][i] =
            d_dt_chaste_interface__L_type_Ca_channel_f_11_gate__f_11;
        outarray[7][i] =
            d_dt_chaste_interface__L_type_Ca_channel_f_12_gate__f_12;
        outarray[8][i] =
            d_dt_chaste_interface__L_type_Ca_channel_Ca_inact_gate__Ca_inact;
        outarray[9][i] =
            d_dt_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__r;
        outarray[10][i] =
            d_dt_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__s;
        outarray[11][i] =
            d_dt_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__s_slow;
        outarray[12][i] =
            d_dt_chaste_interface__steady_state_outward_K_current_r_ss_gate__r_ss;
        outarray[13][i] =
            d_dt_chaste_interface__steady_state_outward_K_current_s_ss_gate__s_ss;
        outarray[14][i] =
            d_dt_chaste_interface__hyperpolarisation_activated_current_y_gate__y;
        outarray[15][i] = d_dt_chaste_interface__SR_Ca_release_channel__P_O1;
        outarray[16][i] = d_dt_chaste_interface__SR_Ca_release_channel__P_O2;
        outarray[17][i] = d_dt_chaste_interface__SR_Ca_release_channel__P_C1;
        outarray[18][i] = d_dt_chaste_interface__SR_Ca_release_channel__P_C2;
        outarray[19][i] =
            d_dt_chaste_interface__intracellular_and_SR_Ca_fluxes__HTRPNCa;
        outarray[20][i] =
            d_dt_chaste_interface__intracellular_and_SR_Ca_fluxes__LTRPNCa;
        outarray[21][i] =
            d_dt_chaste_interface__intracellular_ion_concentrations__Na_i;
        outarray[22][i] =
            d_dt_chaste_interface__intracellular_ion_concentrations__Ca_i;
        outarray[23][i] =
            d_dt_chaste_interface__intracellular_ion_concentrations__K_i;
        outarray[24][i] =
            d_dt_chaste_interface__intracellular_ion_concentrations__Ca_ss;
        outarray[25][i] =
            d_dt_chaste_interface__intracellular_ion_concentrations__Ca_JSR;
        outarray[26][i] =
            d_dt_chaste_interface__intracellular_ion_concentrations__Ca_NSR;
    }
}
 
/**
 *
 */
void PanditGilesDemir03::v_GenerateSummary(SummaryList &s)
{
    SolverUtils::AddSummaryItem(s, "Cell model", "PanditGilesDemir03");
}
 
/**
 *
 */
void PanditGilesDemir03::v_SetInitialConditions()
{
    ASSERTL0(false, "PanditGilesDemir03 cell model not currently usable.");
}
 
} // namespace Nektar