#include <PanditGilesDemir03.h>
Inheritance diagram for Nektar::PanditGilesDemir03:
Public Member Functions | |
| PanditGilesDemir03 (const LibUtilities::SessionReaderSharedPtr &pSession, const MultiRegions::ExpListSharedPtr &pField) | |
| Constructor. More... | |
| ~PanditGilesDemir03 () override | |
| Desctructor. More... | |
 Public Member Functions inherited from Nektar::CellModel | |
| CellModel (const LibUtilities::SessionReaderSharedPtr &pSession, const MultiRegions::ExpListSharedPtr &pField) | |
| virtual | ~CellModel () |
| void | Initialise () |
| Initialise the cell model storage and set initial conditions. More... | |
| void | TimeIntegrate (const Array< OneD, const Array< OneD, NekDouble > > &inarray, Array< OneD, Array< OneD, NekDouble > > &outarray, const NekDouble time) |
| Time integrate the cell model by one PDE timestep. More... | |
| void | Update (const Array< OneD, const Array< OneD, NekDouble > > &inarray, Array< OneD, Array< OneD, NekDouble > > &outarray, const NekDouble time) |
| Compute the derivatives of cell model variables. More... | |
| void | GenerateSummary (SummaryList &s) |
| Print a summary of the cell model. More... | |
| size_t | GetNumCellVariables () |
| std::string | GetCellVarName (size_t idx) |
| Array< OneD, NekDouble > | GetCellSolutionCoeffs (size_t idx) |
| Array< OneD, NekDouble > | GetCellSolution (size_t idx) |
Static Public Member Functions | |
| static CellModelSharedPtr | create (const LibUtilities::SessionReaderSharedPtr &pSession, const MultiRegions::ExpListSharedPtr &pField) |
| Creates an instance of this class. More... | |
Static Public Attributes | |
| static std::string | className |
| Name of class. More... | |
Protected Member Functions | |
| void | v_Update (const Array< OneD, const Array< OneD, NekDouble > > &inarray, Array< OneD, Array< OneD, NekDouble > > &outarray, const NekDouble time) override |
| Computes the reaction terms $f(u,v)$ and $g(u,v)$. More... | |
| void | v_GenerateSummary (SummaryList &s) override |
| Prints a summary of the model parameters. More... | |
| void | v_SetInitialConditions () override |
| Set initial conditions for the cell model. More... | |
| Protected Member Functions inherited from Nektar::CellModel | |
| virtual void | v_Update (const Array< OneD, const Array< OneD, NekDouble > > &inarray, Array< OneD, Array< OneD, NekDouble > > &outarray, const NekDouble time)=0 |
| virtual void | v_GenerateSummary (SummaryList &s)=0 |
| virtual std::string | v_GetCellVarName (size_t idx) |
| virtual void | v_SetInitialConditions ()=0 |
| void | LoadCellModel () |
Additional Inherited Members | |
| Protected Attributes inherited from Nektar::CellModel | |
| LibUtilities::SessionReaderSharedPtr | m_session |
| Session. More... | |
| MultiRegions::ExpListSharedPtr | m_field |
| Transmembrane potential field from PDE system. More... | |
| size_t | m_nq |
| Number of physical points. More... | |
| size_t | m_nvar |
| Number of variables in cell model (inc. transmembrane voltage) More... | |
| NekDouble | m_lastTime |
| Timestep for pde model. More... | |
| size_t | m_substeps |
| Number of substeps to take. More... | |
| Array< OneD, Array< OneD, NekDouble > > | m_cellSol |
| Cell model solution variables. More... | |
| Array< OneD, Array< OneD, NekDouble > > | m_wsp |
| Cell model integration workspace. More... | |
| bool | m_useNodal |
| Flag indicating whether nodal projection in use. More... | |
| StdRegions::StdNodalTriExpSharedPtr | m_nodalTri |
| StdNodalTri for cell model calculations. More... | |
| StdRegions::StdNodalTetExpSharedPtr | m_nodalTet |
| Array< OneD, Array< OneD, NekDouble > > | m_nodalTmp |
| Temporary array for nodal projection. More... | |
| std::vector< int > | m_concentrations |
| Indices of cell model variables which are concentrations. More... | |
| std::vector< int > | m_gates |
| Indices of cell model variables which are gates. More... | |
| Array< OneD, Array< OneD, NekDouble > > | m_gates_tau |
| Storage for gate tau values. More... | |
Detailed Description
Definition at line 41 of file PanditGilesDemir03.h.
Constructor & Destructor Documentation
◆ PanditGilesDemir03()
| Nektar::PanditGilesDemir03::PanditGilesDemir03 | ( | const LibUtilities::SessionReaderSharedPtr & | pSession, |
| const MultiRegions::ExpListSharedPtr & | pField | ||
| ) |
Constructor.
Definition at line 50 of file PanditGilesDemir03.cpp.
53 : CellModel(pSession, pField)
54{
55}
CellModel(const LibUtilities::SessionReaderSharedPtr &pSession, const MultiRegions::ExpListSharedPtr &pField)
Definition: CellModel.cpp:66
◆ ~PanditGilesDemir03()
|
inlineoverride |
Member Function Documentation
◆ create()
|
inlinestatic |
Creates an instance of this class.
Definition at line 46 of file PanditGilesDemir03.h.
49 {
51 pField);
52 }
static std::shared_ptr< DataType > AllocateSharedPtr(const Args &...args)
Allocate a shared pointer from the memory pool.
Definition: NekMemoryManager.hpp:166
References Nektar::MemoryManager< DataType >::AllocateSharedPtr().
◆ v_GenerateSummary()
|
overrideprotectedvirtual |
Prints a summary of the model parameters.
Implements Nektar::CellModel.
Definition at line 1489 of file PanditGilesDemir03.cpp.
1490{
1492}
void AddSummaryItem(SummaryList &l, const std::string &name, const std::string &value)
Adds a summary item to the summary info list.
Definition: Misc.cpp:47
References Nektar::SolverUtils::AddSummaryItem().
◆ v_SetInitialConditions()
|
overrideprotectedvirtual |
Set initial conditions for the cell model.
Implements Nektar::CellModel.
Definition at line 1497 of file PanditGilesDemir03.cpp.
1498{
1500}
References ASSERTL0.
◆ v_Update()
|
overrideprotectedvirtual |
Computes the reaction terms $f(u,v)$ and $g(u,v)$.
Implements Nektar::CellModel.
Definition at line 57 of file PanditGilesDemir03.cpp.
61{
63 {
64 // Inputs:
65 // Time units: millisecond
66 NekDouble var_chaste_interface__membrane__V = inarray[0][i];
67 // Units: millivolt; Initial value: -80.50146
68 NekDouble var_chaste_interface__sodium_current_m_gate__m =
69 inarray[2][i];
70 // Units: dimensionless; Initial value: 0.004164108
71 NekDouble var_chaste_interface__sodium_current_h_gate__h =
72 inarray[3][i];
73 // Units: dimensionless; Initial value: 0.6735613
74 NekDouble var_chaste_interface__sodium_current_j_gate__j =
75 inarray[4][i];
76 // Units: dimensionless; Initial value: 0.6729362
77 NekDouble var_chaste_interface__L_type_Ca_channel_d_gate__d =
78 inarray[5][i];
79 // Units: dimensionless; Initial value: 0.000002171081
80 NekDouble var_chaste_interface__L_type_Ca_channel_f_11_gate__f_11 =
81 inarray[6][i];
82 // Units: dimensionless; Initial value: 0.9999529
83 NekDouble var_chaste_interface__L_type_Ca_channel_f_12_gate__f_12 =
84 inarray[7][i];
85 // Units: dimensionless; Initial value: 0.9999529
86 NekDouble
87 var_chaste_interface__L_type_Ca_channel_Ca_inact_gate__Ca_inact =
88 inarray[8][i];
89 // Units: dimensionless; Initial value: 0.9913102
90 NekDouble
91 var_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__r =
92 inarray[9][i];
93 // Units: dimensionless; Initial value: 0.002191519
94 NekDouble
95 var_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__s =
96 inarray[10][i];
97 // Units: dimensionless; Initial value: 0.9842542
98 NekDouble
99 var_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__s_slow =
100 inarray[11][i];
101 // Units: dimensionless; Initial value: 0.6421196
102 NekDouble
103 var_chaste_interface__steady_state_outward_K_current_r_ss_gate__r_ss =
104 inarray[12][i];
105 // Units: dimensionless; Initial value: 0.002907171
106 NekDouble
107 var_chaste_interface__steady_state_outward_K_current_s_ss_gate__s_ss =
108 inarray[13][i];
109 // Units: dimensionless; Initial value: 0.3142767
110 NekDouble
111 var_chaste_interface__hyperpolarisation_activated_current_y_gate__y =
112 inarray[14][i];
113 // Units: dimensionless; Initial value: 0.003578708
114 NekDouble var_chaste_interface__SR_Ca_release_channel__P_O1 =
115 inarray[15][i];
116 // Units: dimensionless; Initial value: 0.0004327548
117 NekDouble var_chaste_interface__SR_Ca_release_channel__P_O2 =
118 inarray[16][i];
119 // Units: dimensionless; Initial value: 0.000000000606254
120 NekDouble var_chaste_interface__SR_Ca_release_channel__P_C1 =
121 inarray[17][i];
122 // Units: dimensionless; Initial value: 0.6348229
123 NekDouble var_chaste_interface__SR_Ca_release_channel__P_C2 =
124 inarray[18][i];
125 // Units: dimensionless; Initial value: 0.3647471
126 NekDouble
127 var_chaste_interface__intracellular_and_SR_Ca_fluxes__HTRPNCa =
128 inarray[19][i];
129 // Units: millimolar; Initial value: 1.394301e-1
130 NekDouble
131 var_chaste_interface__intracellular_and_SR_Ca_fluxes__LTRPNCa =
132 inarray[20][i];
133 // Units: millimolar; Initial value: 5.1619e-3
134 NekDouble var_chaste_interface__intracellular_ion_concentrations__Na_i =
135 inarray[21][i];
136 // Units: millimolar; Initial value: 10.73519
137 NekDouble var_chaste_interface__intracellular_ion_concentrations__Ca_i =
138 inarray[22][i];
139 // Units: millimolar; Initial value: 0.00007901351
140 NekDouble var_chaste_interface__intracellular_ion_concentrations__K_i =
141 inarray[23][i];
142 // Units: millimolar; Initial value: 139.2751
143 NekDouble
144 var_chaste_interface__intracellular_ion_concentrations__Ca_ss =
145 inarray[24][i];
146 // Units: millimolar; Initial value: 0.00008737212
147 NekDouble
148 var_chaste_interface__intracellular_ion_concentrations__Ca_JSR =
149 inarray[25][i];
150 // Units: millimolar; Initial value: 0.06607948
151 NekDouble
152 var_chaste_interface__intracellular_ion_concentrations__Ca_NSR =
153 inarray[26][i];
154 // Units: millimolar; Initial value: 0.06600742
155
156 // Mathematics
157 NekDouble d_dt_chaste_interface__membrane__V;
162 var_membrane__F; // coulomb_per_mole
164 140.0; // millimolar
166 var_standard_ionic_concentrations__Na_o; // millimolar
169 var_membrane__R; // millijoule_per_mole_kelvin
171 var_chaste_interface__intracellular_ion_concentrations__Na_i; // millimolar
173 ((var_sodium_current__R * var_sodium_current__T) /
174 var_sodium_current__F) *
175 log(var_sodium_current__Na_o /
176 var_sodium_current__Na_i); // millivolt
178 var_chaste_interface__sodium_current_m_gate__m; // dimensionless
180 var_chaste_interface__sodium_current_j_gate__j; // dimensionless
182 var_chaste_interface__sodium_current_h_gate__h; // dimensionless
184 var_chaste_interface__membrane__V; // millivolt
187 var_sodium_current__g_Na * pow(var_sodium_current__m, 3.0) *
188 var_sodium_current__h * var_sodium_current__j *
189 (var_sodium_current__V - var_sodium_current__E_Na); // nanoA
191 var_chaste_interface__L_type_Ca_channel_d_gate__d; // dimensionless
196 var_membrane__Diabetes; // dimensionless
198 (var_L_type_Ca_channel__Diabetes == 0.0)
199 ? var_L_type_Ca_channel__g_Ca_L_normal
200 : (0.76 * var_L_type_Ca_channel__g_Ca_L_normal); // microS
202 var_chaste_interface__L_type_Ca_channel_f_12_gate__f_12; // dimensionless
204 var_chaste_interface__L_type_Ca_channel_f_11_gate__f_11; // dimensionless
206 var_chaste_interface__membrane__V; // millivolt
208 var_chaste_interface__L_type_Ca_channel_Ca_inact_gate__Ca_inact; // dimensionless
210 var_L_type_Ca_channel__g_Ca_L * var_L_type_Ca_channel__d *
211 (((0.9 + (var_L_type_Ca_channel__Ca_inact / 10.0)) *
212 var_L_type_Ca_channel__f_11) +
213 ((0.1 - (var_L_type_Ca_channel__Ca_inact / 10.0)) *
214 var_L_type_Ca_channel__f_12)) *
215 (var_L_type_Ca_channel__V - var_L_type_Ca_channel__E_Ca_L); // nanoA
217 var_Ca_independent_transient_outward_K_current__Diabetes =
218 var_membrane__Diabetes; // dimensionless
220 (var_Ca_independent_transient_outward_K_current__Diabetes == 0.0)
221 ? 0.114
222 : 0.31; // dimensionless
224 1.0 -
225 var_Ca_independent_transient_outward_K_current__b; // dimensionless
227 var_Ca_independent_transient_outward_K_current__g_t_normal =
228 0.04375; // microS
230 (var_Ca_independent_transient_outward_K_current__Diabetes == 0.0)
231 ? var_Ca_independent_transient_outward_K_current__g_t_normal
232 : (0.68 *
233 var_Ca_independent_transient_outward_K_current__g_t_normal); // microS
235 var_chaste_interface__membrane__V; // millivolt
237 var_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__r; // dimensionless
239 var_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__s; // dimensionless
241 var_membrane__F; // coulomb_per_mole
243 var_membrane__T; // kelvin
245 var_chaste_interface__intracellular_ion_concentrations__K_i; // millimolar
247 var_membrane__R; // millijoule_per_mole_kelvin
249 5.4; // millimolar
251 var_standard_ionic_concentrations__K_o; // millimolar
253 ((var_Ca_independent_transient_outward_K_current__R *
254 var_Ca_independent_transient_outward_K_current__T) /
255 var_Ca_independent_transient_outward_K_current__F) *
256 log(var_Ca_independent_transient_outward_K_current__K_o /
257 var_Ca_independent_transient_outward_K_current__K_i); // millivolt
259 var_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__s_slow; // dimensionless
261 var_Ca_independent_transient_outward_K_current__g_t *
262 var_Ca_independent_transient_outward_K_current__r *
263 ((var_Ca_independent_transient_outward_K_current__a *
264 var_Ca_independent_transient_outward_K_current__s) +
265 (var_Ca_independent_transient_outward_K_current__b *
266 var_Ca_independent_transient_outward_K_current__s_slow)) *
267 (var_Ca_independent_transient_outward_K_current__V -
268 var_Ca_independent_transient_outward_K_current__E_K); // nanoA
270 var_chaste_interface__membrane__V; // millivolt
272 var_chaste_interface__steady_state_outward_K_current_s_ss_gate__s_ss; // dimensionless
274 var_Ca_independent_transient_outward_K_current__E_K; // millivolt
276 0.0077; // microS
278 var_membrane__Diabetes; // dimensionless
280 (var_steady_state_outward_K_current__Diabetes == 0.0)
281 ? var_steady_state_outward_K_current__g_ss_normal
282 : (0.77 *
283 var_steady_state_outward_K_current__g_ss_normal); // microS
285 var_chaste_interface__steady_state_outward_K_current_r_ss_gate__r_ss; // dimensionless
287 var_steady_state_outward_K_current__g_ss *
288 var_steady_state_outward_K_current__r_ss *
289 var_steady_state_outward_K_current__s_ss *
290 (var_steady_state_outward_K_current__V -
291 var_steady_state_outward_K_current__E_K); // nanoA
293 0.2; // dimensionless
295 var_sodium_current__E_Na; // millivolt
297 var_chaste_interface__hyperpolarisation_activated_current_y_gate__y; // dimensionless
299 var_chaste_interface__membrane__V; // millivolt
301 0.00145; // microS
303 var_hyperpolarisation_activated_current__g_f *
304 var_hyperpolarisation_activated_current__y *
305 var_hyperpolarisation_activated_current__f_Na *
306 (var_hyperpolarisation_activated_current__V -
307 var_hyperpolarisation_activated_current__E_Na); // nanoA
309 1.0 -
310 var_hyperpolarisation_activated_current__f_Na; // dimensionless
312 var_Ca_independent_transient_outward_K_current__E_K; // millivolt
314 var_hyperpolarisation_activated_current__g_f *
315 var_hyperpolarisation_activated_current__y *
316 var_hyperpolarisation_activated_current__f_K *
317 (var_hyperpolarisation_activated_current__V -
318 var_hyperpolarisation_activated_current__E_K); // nanoA
321 var_chaste_interface__membrane__V; // millivolt
324 var_membrane__R; // millijoule_per_mole_kelvin
326 var_standard_ionic_concentrations__K_o; // millimolar
328 var_membrane__F; // coulomb_per_mole
330 var_Ca_independent_transient_outward_K_current__E_K; // millivolt
332 ((((48.0 / (exp((var_inward_rectifier__V + 37.0) / 25.0) +
333 exp((var_inward_rectifier__V + 37.0) / (-25.0)))) +
334 10.0) *
335 0.0001) /
336 (1.0 + exp((var_inward_rectifier__V -
337 (var_inward_rectifier__E_K + 76.77)) /
338 (-17.0)))) +
339 ((var_inward_rectifier__g_K1 *
340 (var_inward_rectifier__V - (var_inward_rectifier__E_K + 1.73))) /
341 ((1.0 + exp((1.613 * var_inward_rectifier__F *
342 (var_inward_rectifier__V -
343 (var_inward_rectifier__E_K + 1.73))) /
344 (var_inward_rectifier__R * var_inward_rectifier__T))) *
345 (1.0 +
346 exp((var_inward_rectifier__K_o - 0.9988) / (-0.124))))); // nanoA
348 var_membrane__R; // millijoule_per_mole_kelvin
350 var_chaste_interface__intracellular_ion_concentrations__Ca_i; // millimolar
352 1.2; // millimolar
354 var_standard_ionic_concentrations__Ca_o; // millimolar
356 var_membrane__F; // coulomb_per_mole
359 ((0.5 * var_background_currents__R * var_background_currents__T) /
360 var_background_currents__F) *
361 log(var_background_currents__Ca_o /
362 var_background_currents__Ca_i); // millivolt
364 var_chaste_interface__membrane__V; // millivolt
366 3.24e-05; // microS
368 var_membrane__Diabetes; // dimensionless
370 (var_background_currents__Diabetes == 0.0)
371 ? var_background_currents__g_B_Ca_normal
372 : (0.5 * var_background_currents__g_B_Ca_normal); // microS
374 var_background_currents__g_B_Ca *
375 (var_background_currents__V -
376 var_background_currents__E_Ca); // nanoA
379 var_Ca_independent_transient_outward_K_current__E_K; // millivolt
381 var_background_currents__g_B_K *
382 (var_background_currents__V -
383 var_background_currents__E_K); // nanoA
385 var_sodium_current__E_Na; // millivolt
387 8.015e-05; // microS
389 (var_background_currents__Diabetes == 0.0)
390 ? var_background_currents__g_B_Na_normal
391 : (1.25 * var_background_currents__g_B_Na_normal); // microS
393 var_background_currents__g_B_Na *
394 (var_background_currents__V -
395 var_background_currents__E_Na); // nanoA
397 var_standard_ionic_concentrations__Na_o; // millimolar
399 (exp(var_sodium_potassium_pump__Na_o / 67.3) - 1.0) /
400 7.0; // dimensionless
404 var_chaste_interface__membrane__V; // millivolt
406 var_membrane__T; // kelvin
408 var_membrane__R; // millijoule_per_mole_kelvin
410 var_chaste_interface__intracellular_ion_concentrations__Na_i; // millimolar
412 var_membrane__F; // coulomb_per_mole
414 0.08; // nanoA
416 var_membrane__Diabetes; // dimensionless
418 (var_sodium_potassium_pump__Diabetes == 0.0)
419 ? var_sodium_potassium_pump__i_NaK_max_normal
420 : (0.63 * var_sodium_potassium_pump__i_NaK_max_normal); // nanoA
422 var_standard_ionic_concentrations__K_o; // millimolar
424 (((var_sodium_potassium_pump__i_NaK_max /
425 (1.0 +
426 (0.1245 * exp(((-0.1) * var_sodium_potassium_pump__V *
427 var_sodium_potassium_pump__F) /
428 (var_sodium_potassium_pump__R *
429 var_sodium_potassium_pump__T))) +
430 (0.0365 * var_sodium_potassium_pump__sigma *
431 exp(((-var_sodium_potassium_pump__V) *
432 var_sodium_potassium_pump__F) /
433 (var_sodium_potassium_pump__R *
434 var_sodium_potassium_pump__T))))) *
435 var_sodium_potassium_pump__K_o) /
436 (var_sodium_potassium_pump__K_o +
437 var_sodium_potassium_pump__K_m_K)) /
438 (1.0 + pow(var_sodium_potassium_pump__K_m_Na /
439 var_sodium_potassium_pump__Na_i,
440 1.5)); // nanoA
442 var_standard_ionic_concentrations__Na_o; // millimolar
444 var_chaste_interface__intracellular_ion_concentrations__Na_i; // millimolar
446 0.5; // dimensionless
448 var_chaste_interface__intracellular_ion_concentrations__Ca_i; // millimolar
450 var_standard_ionic_concentrations__Ca_o; // millimolar
452 9.984e-06; // nanoA_millimolar_4
454 0.0001; // millimolar_4
456 var_chaste_interface__membrane__V; // millivolt
458 (var_Na_Ca_ion_exchanger_current__K_NaCa *
459 ((pow(var_Na_Ca_ion_exchanger_current__Na_i, 3.0) *
460 var_Na_Ca_ion_exchanger_current__Ca_o *
461 exp(0.03743 * var_Na_Ca_ion_exchanger_current__V *
462 var_Na_Ca_ion_exchanger_current__gamma_NaCa)) -
463 (pow(var_Na_Ca_ion_exchanger_current__Na_o, 3.0) *
464 var_Na_Ca_ion_exchanger_current__Ca_i *
465 exp(0.03743 * var_Na_Ca_ion_exchanger_current__V *
466 (var_Na_Ca_ion_exchanger_current__gamma_NaCa - 1.0))))) /
467 (1.0 +
468 (var_Na_Ca_ion_exchanger_current__d_NaCa *
469 ((var_Na_Ca_ion_exchanger_current__Ca_i *
470 pow(var_Na_Ca_ion_exchanger_current__Na_o, 3.0)) +
471 (var_Na_Ca_ion_exchanger_current__Ca_o *
472 pow(var_Na_Ca_ion_exchanger_current__Na_i, 3.0))))); // nanoA
474 var_chaste_interface__intracellular_ion_concentrations__Ca_i; // millimolar
476 0.004; // nanoA
478 (var_sarcolemmal_calcium_pump_current__i_Ca_P_max *
479 var_sarcolemmal_calcium_pump_current__Ca_i) /
480 (var_sarcolemmal_calcium_pump_current__Ca_i + 0.0004); // nanoA
482 var_sodium_current__V; // millivolt
484 1.0 / (1.0 + exp((var_sodium_current_m_gate__V + 45.0) /
485 (-6.5))); // dimensionless
487 0.00136 /
488 (((0.32 * (var_sodium_current_m_gate__V + 47.13)) /
489 (1.0 - exp((-0.1) * (var_sodium_current_m_gate__V + 47.13)))) +
490 (0.08 * exp((-var_sodium_current_m_gate__V) / 11.0))); // second
492 var_sodium_current__m; // dimensionless
494 (var_sodium_current_m_gate__m_infinity -
495 var_sodium_current_m_gate__m) /
496 var_sodium_current_m_gate__tau_m; // per_second
498 var_sodium_current__sodium_current_m_gate__d_m_d_environment__time =
499 var_sodium_current_m_gate__d_m_d_environment__time; // per_second
501 var_sodium_current__V; // millivolt
503 1.0 / (1.0 + exp((var_sodium_current_h_gate__V + 76.1) /
504 6.07)); // dimensionless
506 var_sodium_current__h; // dimensionless
508 (var_sodium_current_h_gate__V >= (-40.0))
509 ? (0.0004537 *
510 (1.0 +
511 exp((-(var_sodium_current_h_gate__V + 10.66)) / 11.1)))
512 : (0.00349 /
513 ((0.135 *
514 exp((-(var_sodium_current_h_gate__V + 80.0)) / 6.8)) +
515 (3.56 * exp(0.079 * var_sodium_current_h_gate__V)) +
516 (310000.0 *
517 exp(0.35 * var_sodium_current_h_gate__V)))); // second
519 (var_sodium_current_h_gate__h_infinity -
520 var_sodium_current_h_gate__h) /
521 var_sodium_current_h_gate__tau_h; // per_second
523 var_sodium_current__sodium_current_h_gate__d_h_d_environment__time =
524 var_sodium_current_h_gate__d_h_d_environment__time; // per_second
526 var_sodium_current__V; // millivolt
528 1.0 / (1.0 + exp((var_sodium_current_j_gate__V + 76.1) /
529 6.07)); // dimensionless
531 var_sodium_current__j; // dimensionless
533 (var_sodium_current_j_gate__V >= (-40.0))
534 ? ((0.01163 *
535 (1.0 +
536 exp((-0.1) * (var_sodium_current_j_gate__V + 32.0)))) /
537 exp((-2.535e-07) * var_sodium_current_j_gate__V))
538 : (0.00349 /
539 ((((var_sodium_current_j_gate__V + 37.78) /
540 (1.0 +
541 exp(0.311 * (var_sodium_current_j_gate__V + 79.23)))) *
542 (((-127140.0) *
543 exp(0.2444 * var_sodium_current_j_gate__V)) -
544 (3.474e-05 *
545 exp((-0.04391) * var_sodium_current_j_gate__V)))) +
546 ((0.1212 * exp((-0.01052) * var_sodium_current_j_gate__V)) /
547 (1.0 + exp((-0.1378) * (var_sodium_current_j_gate__V +
548 40.14)))))); // second
550 (var_sodium_current_j_gate__j_infinity -
551 var_sodium_current_j_gate__j) /
552 var_sodium_current_j_gate__tau_j; // per_second
554 var_sodium_current__sodium_current_j_gate__d_j_d_environment__time =
555 var_sodium_current_j_gate__d_j_d_environment__time; // per_second
557 var_chaste_interface__intracellular_ion_concentrations__Ca_ss; // millimolar
559 var_L_type_Ca_channel__d; // dimensionless
561 var_L_type_Ca_channel__V; // millivolt
563 1.0 / (1.0 + exp((var_L_type_Ca_channel_d_gate__V + 15.3) /
564 (-5.0))); // dimensionless
566 (0.00305 *
567 exp((-0.0045) * pow(var_L_type_Ca_channel_d_gate__V + 7.0, 2.0))) +
568 (0.00105 *
569 exp((-0.002) * pow(var_L_type_Ca_channel_d_gate__V - 18.0, 2.0))) +
570 0.00025; // second
572 (var_L_type_Ca_channel_d_gate__d_infinity -
573 var_L_type_Ca_channel_d_gate__d) /
574 var_L_type_Ca_channel_d_gate__tau_d; // per_second
576 var_L_type_Ca_channel__L_type_Ca_channel_d_gate__d_d_d_environment__time =
577 var_L_type_Ca_channel_d_gate__d_d_d_environment__time; // per_second
579 var_L_type_Ca_channel__f_11; // dimensionless
581 var_L_type_Ca_channel__Diabetes; // dimensionless
583 var_L_type_Ca_channel__V; // millivolt
585 (var_L_type_Ca_channel_f_11_gate__Diabetes == 0.0)
586 ? ((0.105 *
587 exp(-pow((var_L_type_Ca_channel_f_11_gate__V + 45.0) / 12.0,
588 2.0))) +
589 (0.04 /
590 (1.0 + exp(((-var_L_type_Ca_channel_f_11_gate__V) + 25.0) /
591 25.0))) +
592 (0.015 /
593 (1.0 +
594 exp((var_L_type_Ca_channel_f_11_gate__V + 75.0) / 25.0))) +
595 0.0017)
596 : ((0.9 * 0.105 *
597 exp(-pow((var_L_type_Ca_channel_f_11_gate__V + 45.0) / 12.0,
598 2.0))) +
599 (0.04 /
600 (1.0 + exp(((-var_L_type_Ca_channel_f_11_gate__V) + 25.0) /
601 25.0))) +
602 (0.015 /
603 (1.0 +
604 exp((var_L_type_Ca_channel_f_11_gate__V + 75.0) / 25.0))) +
605 0.0017); // second
607 1.0 / (1.0 + exp((var_L_type_Ca_channel_f_11_gate__V + 26.7) /
608 5.4)); // dimensionless
610 var_L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time =
611 (var_L_type_Ca_channel_f_11_gate__f_11_infinity -
612 var_L_type_Ca_channel_f_11_gate__f_11) /
613 var_L_type_Ca_channel_f_11_gate__tau_f_11; // per_second
615 var_L_type_Ca_channel__L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time =
616 var_L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time; // per_second
618 var_L_type_Ca_channel__f_12; // dimensionless
620 var_L_type_Ca_channel__V; // millivolt
622 1.0 / (1.0 + exp((var_L_type_Ca_channel_f_12_gate__V + 26.7) /
623 5.4)); // dimensionless
625 (0.041 *
626 exp(-pow((var_L_type_Ca_channel_f_12_gate__V + 47.0) / 12.0,
627 2.0))) +
628 (0.08 / (1.0 + exp((var_L_type_Ca_channel_f_12_gate__V + 55.0) /
629 (-5.0)))) +
630 (0.015 /
631 (1.0 + exp((var_L_type_Ca_channel_f_12_gate__V + 75.0) / 25.0))) +
632 0.0017; // second
634 var_L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time =
635 (var_L_type_Ca_channel_f_12_gate__f_12_infinity -
636 var_L_type_Ca_channel_f_12_gate__f_12) /
637 var_L_type_Ca_channel_f_12_gate__tau_f_12; // per_second
639 var_L_type_Ca_channel__L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time =
640 var_L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time; // per_second
642 var_L_type_Ca_channel__Ca_ss; // millimolar
644 1.0 / (1.0 + (var_L_type_Ca_channel_Ca_inact_gate__Ca_ss /
645 0.01)); // dimensionless
647 0.009; // second
649 var_L_type_Ca_channel__Ca_inact; // dimensionless
651 var_L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time =
652 (var_L_type_Ca_channel_Ca_inact_gate__Ca_inact_infinity -
653 var_L_type_Ca_channel_Ca_inact_gate__Ca_inact) /
654 var_L_type_Ca_channel_Ca_inact_gate__tau_Ca_inact; // per_second
656 var_L_type_Ca_channel__L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time =
657 var_L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time; // per_second
659 var_Ca_independent_transient_outward_K_current_r_gate__V =
660 var_Ca_independent_transient_outward_K_current__V; // millivolt
662 var_Ca_independent_transient_outward_K_current_r_gate__r_infinity =
663 1.0 /
664 (1.0 +
665 exp((var_Ca_independent_transient_outward_K_current_r_gate__V +
666 10.6) /
667 (-11.42))); // dimensionless
669 var_Ca_independent_transient_outward_K_current__r; // dimensionless
671 var_Ca_independent_transient_outward_K_current_r_gate__tau_r =
672 1.0 /
673 ((45.16 *
674 exp(0.03577 *
675 (var_Ca_independent_transient_outward_K_current_r_gate__V +
676 50.0))) +
677 (98.9 *
678 exp((-0.1) *
679 (var_Ca_independent_transient_outward_K_current_r_gate__V +
680 38.0)))); // second
682 var_Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time =
683 (var_Ca_independent_transient_outward_K_current_r_gate__r_infinity -
684 var_Ca_independent_transient_outward_K_current_r_gate__r) /
685 var_Ca_independent_transient_outward_K_current_r_gate__tau_r; // per_second
687 var_Ca_independent_transient_outward_K_current__Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time =
688 var_Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time; // per_second
690 var_Ca_independent_transient_outward_K_current_s_gate__V =
691 var_Ca_independent_transient_outward_K_current__V; // millivolt
693 var_Ca_independent_transient_outward_K_current_s_gate__s_infinity =
694 1.0 /
695 (1.0 +
696 exp((var_Ca_independent_transient_outward_K_current_s_gate__V +
697 45.3) /
698 6.8841)); // dimensionless
700 var_Ca_independent_transient_outward_K_current_s_gate__tau_s =
701 (0.35 *
702 exp(-pow(
703 (var_Ca_independent_transient_outward_K_current_s_gate__V +
704 70.0) /
705 15.0,
706 2.0))) +
707 0.035; // second
709 var_Ca_independent_transient_outward_K_current__s; // dimensionless
711 var_Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time =
712 (var_Ca_independent_transient_outward_K_current_s_gate__s_infinity -
713 var_Ca_independent_transient_outward_K_current_s_gate__s) /
714 var_Ca_independent_transient_outward_K_current_s_gate__tau_s; // per_second
716 var_Ca_independent_transient_outward_K_current__Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time =
717 var_Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time; // per_second
719 var_Ca_independent_transient_outward_K_current_s_slow_gate__V =
720 var_Ca_independent_transient_outward_K_current__V; // millivolt
722 var_Ca_independent_transient_outward_K_current_s_slow_gate__s_slow_infinity =
723 1.0 /
724 (1.0 +
725 exp((var_Ca_independent_transient_outward_K_current_s_slow_gate__V +
726 45.3) /
727 6.8841)); // dimensionless
729 var_Ca_independent_transient_outward_K_current_s_slow_gate__s_slow =
730 var_Ca_independent_transient_outward_K_current__s_slow; // dimensionless
732 var_Ca_independent_transient_outward_K_current_s_slow_gate__tau_s_slow =
733 (3.7 *
734 exp(-pow(
735 (var_Ca_independent_transient_outward_K_current_s_slow_gate__V +
736 70.0) /
737 30.0,
738 2.0))) +
739 0.035; // second
740 const NekDouble var_Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time =
741 (var_Ca_independent_transient_outward_K_current_s_slow_gate__s_slow_infinity -
742 var_Ca_independent_transient_outward_K_current_s_slow_gate__s_slow) /
743 var_Ca_independent_transient_outward_K_current_s_slow_gate__tau_s_slow; // per_second
745 var_Ca_independent_transient_outward_K_current__Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time =
746 var_Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time; // per_second
748 var_steady_state_outward_K_current__V; // millivolt
750 var_steady_state_outward_K_current_r_ss_gate__r_ss_infinity =
751 1.0 /
752 (1.0 +
753 exp((var_steady_state_outward_K_current_r_ss_gate__V + 11.5) /
754 (-11.82))); // dimensionless
756 var_steady_state_outward_K_current__r_ss; // dimensionless
758 10.0 /
759 ((45.16 *
760 exp(0.03577 *
761 (var_steady_state_outward_K_current_r_ss_gate__V + 50.0))) +
762 (98.9 *
763 exp((-0.1) * (var_steady_state_outward_K_current_r_ss_gate__V +
764 38.0)))); // second
766 var_steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time =
767 (var_steady_state_outward_K_current_r_ss_gate__r_ss_infinity -
768 var_steady_state_outward_K_current_r_ss_gate__r_ss) /
769 var_steady_state_outward_K_current_r_ss_gate__tau_r_ss; // per_second
771 var_steady_state_outward_K_current__steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time =
772 var_steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time; // per_second
774 var_steady_state_outward_K_current__s_ss; // dimensionless
776 2.1; // second
778 var_steady_state_outward_K_current__V; // millivolt
780 var_steady_state_outward_K_current_s_ss_gate__s_ss_infinity =
781 1.0 /
782 (1.0 +
783 exp((var_steady_state_outward_K_current_s_ss_gate__V + 87.5) /
784 10.3)); // dimensionless
786 var_steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time =
787 (var_steady_state_outward_K_current_s_ss_gate__s_ss_infinity -
788 var_steady_state_outward_K_current_s_ss_gate__s_ss) /
789 var_steady_state_outward_K_current_s_ss_gate__tau_s_ss; // per_second
791 var_steady_state_outward_K_current__steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time =
792 var_steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time; // per_second
794 var_hyperpolarisation_activated_current__V; // millivolt
796 1.0 /
797 ((0.11885 *
798 exp((var_hyperpolarisation_activated_current_y_gate__V + 80.0) /
799 28.37)) +
800 (0.5623 *
801 exp((var_hyperpolarisation_activated_current_y_gate__V + 80.0) /
802 (-14.19)))); // second
804 var_hyperpolarisation_activated_current__y; // dimensionless
806 var_hyperpolarisation_activated_current_y_gate__y_infinity =
807 1.0 /
808 (1.0 + exp((var_hyperpolarisation_activated_current_y_gate__V +
809 138.6) /
810 10.48)); // dimensionless
812 var_hyperpolarisation_activated_current_y_gate__d_y_d_environment__time =
813 (var_hyperpolarisation_activated_current_y_gate__y_infinity -
814 var_hyperpolarisation_activated_current_y_gate__y) /
815 var_hyperpolarisation_activated_current_y_gate__tau_y; // per_second
817 var_hyperpolarisation_activated_current__hyperpolarisation_activated_current_y_gate__d_y_d_environment__time =
818 var_hyperpolarisation_activated_current_y_gate__d_y_d_environment__time; // per_second
820 var_chaste_interface__intracellular_ion_concentrations__Ca_ss; // millimolar
823 var_chaste_interface__SR_Ca_release_channel__P_O2; // dimensionless
825 var_chaste_interface__SR_Ca_release_channel__P_O1; // dimensionless
827 var_chaste_interface__intracellular_ion_concentrations__Ca_JSR; // millimolar
829 var_SR_Ca_release_channel__v1 *
830 (var_SR_Ca_release_channel__P_O1 +
831 var_SR_Ca_release_channel__P_O2) *
832 (var_SR_Ca_release_channel__Ca_JSR -
833 var_SR_Ca_release_channel__Ca_ss); // millimolar_per_second
835 1.215e+13; // per_second
837 576.0; // per_second
839 4050000000.0; // per_second
841 1930.0; // per_second
843 100.0; // per_second
845 0.8; // per_second
847 var_chaste_interface__SR_Ca_release_channel__P_C1; // dimensionless
849 var_chaste_interface__SR_Ca_release_channel__P_C2; // dimensionless
853 ((var_SR_Ca_release_channel__k_a_plus *
854 pow(var_SR_Ca_release_channel__Ca_ss / 1.0,
855 var_SR_Ca_release_channel__n) *
856 var_SR_Ca_release_channel__P_C1) -
857 ((var_SR_Ca_release_channel__k_a_minus *
858 var_SR_Ca_release_channel__P_O1) +
859 (var_SR_Ca_release_channel__k_b_plus *
860 pow(var_SR_Ca_release_channel__Ca_ss / 1.0,
861 var_SR_Ca_release_channel__m) *
862 var_SR_Ca_release_channel__P_O1) +
863 (var_SR_Ca_release_channel__k_c_plus *
864 var_SR_Ca_release_channel__P_O1))) +
865 (var_SR_Ca_release_channel__k_b_minus *
866 var_SR_Ca_release_channel__P_O2) +
867 (var_SR_Ca_release_channel__k_c_minus *
868 var_SR_Ca_release_channel__P_C2); // per_second
870 (var_SR_Ca_release_channel__k_b_plus *
871 pow(var_SR_Ca_release_channel__Ca_ss / 1.0,
872 var_SR_Ca_release_channel__m) *
873 var_SR_Ca_release_channel__P_O1) -
874 (var_SR_Ca_release_channel__k_b_minus *
875 var_SR_Ca_release_channel__P_O2); // per_second
877 ((-var_SR_Ca_release_channel__k_a_plus) *
878 pow(var_SR_Ca_release_channel__Ca_ss / 1.0,
879 var_SR_Ca_release_channel__n) *
880 var_SR_Ca_release_channel__P_C1) +
881 (var_SR_Ca_release_channel__k_a_minus *
882 var_SR_Ca_release_channel__P_O1); // per_second
884 (var_SR_Ca_release_channel__k_c_plus *
885 var_SR_Ca_release_channel__P_O1) -
886 (var_SR_Ca_release_channel__k_c_minus *
887 var_SR_Ca_release_channel__P_C2); // per_second
891 var_chaste_interface__intracellular_ion_concentrations__Ca_i; // millimolar
893 pow(var_SERCA2a_pump__Ca_i / var_SERCA2a_pump__K_fb,
894 var_SERCA2a_pump__N_fb); // dimensionless
896 var_membrane__Diabetes; // dimensionless
898 0.04; // millimolar_per_second
900 (var_SERCA2a_pump__Diabetes == 0.0)
901 ? var_SERCA2a_pump__Vmaxf_normal
902 : (0.8 *
903 var_SERCA2a_pump__Vmaxf_normal); // millimolar_per_second
906 (var_SERCA2a_pump__Diabetes == 0.0)
907 ? var_SERCA2a_pump__K_SR_normal
908 : (0.55 * var_SERCA2a_pump__K_SR_normal); // dimensionless
910 var_chaste_interface__intracellular_ion_concentrations__Ca_NSR; // millimolar
914 pow(var_SERCA2a_pump__Ca_NSR / var_SERCA2a_pump__K_rb,
915 var_SERCA2a_pump__N_rb); // dimensionless
918 (var_SERCA2a_pump__K_SR *
919 ((var_SERCA2a_pump__Vmaxf * var_SERCA2a_pump__fb) -
920 (var_SERCA2a_pump__Vmaxr * var_SERCA2a_pump__rb))) /
921 (1.0 + var_SERCA2a_pump__fb +
922 var_SERCA2a_pump__rb); // millimolar_per_second
924 0.0005747; // second
926 var_chaste_interface__intracellular_ion_concentrations__Ca_JSR; // millimolar
928 var_chaste_interface__intracellular_ion_concentrations__Ca_NSR; // millimolar
930 (var_intracellular_and_SR_Ca_fluxes__Ca_NSR -
931 var_intracellular_and_SR_Ca_fluxes__Ca_JSR) /
932 var_intracellular_and_SR_Ca_fluxes__tau_tr; // millimolar_per_second
934 var_chaste_interface__intracellular_ion_concentrations__Ca_ss; // millimolar
936 var_chaste_interface__intracellular_ion_concentrations__Ca_i; // millimolar
938 0.0267; // second
940 (var_intracellular_and_SR_Ca_fluxes__Ca_ss -
941 var_intracellular_and_SR_Ca_fluxes__Ca_i) /
942 var_intracellular_and_SR_Ca_fluxes__tau_xfer; // millimolar_per_second
944 200000.0; // per_millimolar_per_second
946 0.066; // per_second
948 var_chaste_interface__intracellular_and_SR_Ca_fluxes__HTRPNCa; // millimolar
950 0.14; // millimolar
952 (var_intracellular_and_SR_Ca_fluxes__k_htrpn_plus *
953 var_intracellular_and_SR_Ca_fluxes__Ca_i *
954 (var_intracellular_and_SR_Ca_fluxes__HTRPN_tot -
955 var_intracellular_and_SR_Ca_fluxes__HTRPNCa)) -
956 (var_intracellular_and_SR_Ca_fluxes__k_htrpn_minus *
957 var_intracellular_and_SR_Ca_fluxes__HTRPNCa); // millimolar_per_second
959 var_chaste_interface__intracellular_and_SR_Ca_fluxes__LTRPNCa; // millimolar
961 0.07; // millimolar
963 40000.0; // per_millimolar_per_second
965 40.0; // per_second
967 (var_intracellular_and_SR_Ca_fluxes__k_ltrpn_plus *
968 var_intracellular_and_SR_Ca_fluxes__Ca_i *
969 (var_intracellular_and_SR_Ca_fluxes__LTRPN_tot -
970 var_intracellular_and_SR_Ca_fluxes__LTRPNCa)) -
971 (var_intracellular_and_SR_Ca_fluxes__k_ltrpn_minus *
972 var_intracellular_and_SR_Ca_fluxes__LTRPNCa); // millimolar_per_second
974 var_intracellular_and_SR_Ca_fluxes__J_HTRPNCa +
975 var_intracellular_and_SR_Ca_fluxes__J_LTRPNCa; // millimolar_per_second
977 var_intracellular_and_SR_Ca_fluxes__d_HTRPNCa_d_environment__time =
978 (var_intracellular_and_SR_Ca_fluxes__k_htrpn_plus *
979 var_intracellular_and_SR_Ca_fluxes__Ca_i *
980 (var_intracellular_and_SR_Ca_fluxes__HTRPN_tot -
981 var_intracellular_and_SR_Ca_fluxes__HTRPNCa)) -
982 (var_intracellular_and_SR_Ca_fluxes__k_htrpn_minus *
983 var_intracellular_and_SR_Ca_fluxes__HTRPNCa); // 'millimole per
984 // litre per
985 // second'
987 var_intracellular_and_SR_Ca_fluxes__d_LTRPNCa_d_environment__time =
988 (var_intracellular_and_SR_Ca_fluxes__k_ltrpn_plus *
989 var_intracellular_and_SR_Ca_fluxes__Ca_i *
990 (var_intracellular_and_SR_Ca_fluxes__LTRPN_tot -
991 var_intracellular_and_SR_Ca_fluxes__LTRPNCa)) -
992 (var_intracellular_and_SR_Ca_fluxes__k_ltrpn_minus *
993 var_intracellular_and_SR_Ca_fluxes__LTRPNCa); // 'millimole per
994 // litre per
995 // second'
997 var_chaste_interface__intracellular_ion_concentrations__Ca_i; // millimolar
999 var_chaste_interface__intracellular_ion_concentrations__Ca_ss; // millimolar
1001 var_chaste_interface__intracellular_ion_concentrations__Ca_JSR; // millimolar
1003 9.36e-06; // micro_litre
1005 5.6e-07; // micro_litre
1007 5.04e-06; // micro_litre
1009 1.2e-08; // micro_litre
1011 0.00238; // millimolar
1013 0.8; // millimolar
1015 0.00015; // millimolar
1017 0.05; // millimolar
1019 15.0; // millimolar
1021 10.0; // millimolar
1023 1.0 / (1.0 +
1024 ((var_intracellular_ion_concentrations__CMDN_tot *
1025 var_intracellular_ion_concentrations__K_mCMDN) /
1026 pow(var_intracellular_ion_concentrations__K_mCMDN +
1027 var_intracellular_ion_concentrations__Ca_i,
1028 2.0)) +
1029 ((var_intracellular_ion_concentrations__EGTA_tot *
1030 var_intracellular_ion_concentrations__K_mEGTA) /
1031 pow(var_intracellular_ion_concentrations__K_mEGTA +
1032 var_intracellular_ion_concentrations__Ca_i,
1033 2.0))); // dimensionless
1035 1.0 / (1.0 + ((var_intracellular_ion_concentrations__CMDN_tot *
1036 var_intracellular_ion_concentrations__K_mCMDN) /
1037 pow(var_intracellular_ion_concentrations__K_mCMDN +
1038 var_intracellular_ion_concentrations__Ca_ss,
1039 2.0))); // dimensionless
1041 1.0 / (1.0 + ((var_intracellular_ion_concentrations__CSQN_tot *
1042 var_intracellular_ion_concentrations__K_mCSQN) /
1043 pow(var_intracellular_ion_concentrations__K_mCSQN +
1044 var_intracellular_ion_concentrations__Ca_JSR,
1045 2.0))); // dimensionless
1047 var_membrane__F; // coulomb_per_mole
1049 var_sodium_current__i_Na; // nanoA
1051 var_L_type_Ca_channel__i_Ca_L; // nanoA
1053 var_background_currents__i_B_Na; // nanoA
1055 var_Na_Ca_ion_exchanger_current__i_NaCa; // nanoA
1057 var_sodium_potassium_pump__i_NaK; // nanoA
1059 var_hyperpolarisation_activated_current__i_f_Na; // nanoA
1061 var_hyperpolarisation_activated_current__i_f_K; // nanoA
1063 var_background_currents__i_B_K; // nanoA
1065 var_inward_rectifier__i_K1; // nanoA
1067 var_Ca_independent_transient_outward_K_current__i_t; // nanoA
1069 var_steady_state_outward_K_current__i_ss; // nanoA
1071 var_sarcolemmal_calcium_pump_current__i_Ca_P; // nanoA
1073 var_background_currents__i_B_Ca; // nanoA
1075 var_SERCA2a_pump__J_up; // millimolar_per_second
1077 var_SR_Ca_release_channel__J_rel; // millimolar_per_second
1079 var_intracellular_and_SR_Ca_fluxes__J_xfer; // millimolar_per_second
1081 var_intracellular_and_SR_Ca_fluxes__J_trpn; // millimolar_per_second
1083 var_intracellular_and_SR_Ca_fluxes__J_tr; // millimolar_per_second
1085 var_intracellular_ion_concentrations__d_Na_i_d_environment__time =
1086 (-(var_intracellular_ion_concentrations__i_Na +
1087 var_intracellular_ion_concentrations__i_B_Na +
1088 (var_intracellular_ion_concentrations__i_NaCa * 3.0) +
1089 (var_intracellular_ion_concentrations__i_NaK * 3.0) +
1090 var_intracellular_ion_concentrations__i_f_Na)) /
1091 (var_intracellular_ion_concentrations__V_myo *
1092 var_intracellular_ion_concentrations__F); // 'millimole per
1093 // litre per second'
1095 var_intracellular_ion_concentrations__d_Ca_i_d_environment__time =
1096 var_intracellular_ion_concentrations__beta_i *
1097 (var_intracellular_ion_concentrations__J_xfer -
1098 (var_intracellular_ion_concentrations__J_up +
1099 var_intracellular_ion_concentrations__J_trpn +
1100 (((var_intracellular_ion_concentrations__i_B_Ca -
1101 (2.0 * var_intracellular_ion_concentrations__i_NaCa)) +
1102 var_intracellular_ion_concentrations__i_Ca_P) /
1103 (2.0 * var_intracellular_ion_concentrations__V_myo *
1104 var_intracellular_ion_concentrations__F)))); // 'millimole
1105 // per litre
1106 // per second'
1108 var_intracellular_ion_concentrations__d_K_i_d_environment__time =
1109 (-(var_intracellular_ion_concentrations__i_ss +
1110 var_intracellular_ion_concentrations__i_B_K +
1111 var_intracellular_ion_concentrations__i_t +
1112 var_intracellular_ion_concentrations__i_K1 +
1113 var_intracellular_ion_concentrations__i_f_K +
1114 (var_intracellular_ion_concentrations__i_NaK * (-2.0)))) /
1115 (var_intracellular_ion_concentrations__V_myo *
1116 var_intracellular_ion_concentrations__F); // 'millimole per
1117 // litre per second'
1119 var_intracellular_ion_concentrations__d_Ca_ss_d_environment__time =
1120 var_intracellular_ion_concentrations__beta_SS *
1121 ((((var_intracellular_ion_concentrations__J_rel *
1122 var_intracellular_ion_concentrations__V_JSR) /
1123 var_intracellular_ion_concentrations__V_SS) -
1124 ((var_intracellular_ion_concentrations__J_xfer *
1125 var_intracellular_ion_concentrations__V_myo) /
1126 var_intracellular_ion_concentrations__V_SS)) -
1127 (var_intracellular_ion_concentrations__i_Ca_L /
1128 (2.0 * var_intracellular_ion_concentrations__V_SS *
1129 var_intracellular_ion_concentrations__F))); // 'millimole per
1130 // litre per
1131 // second'
1133 var_intracellular_ion_concentrations__d_Ca_JSR_d_environment__time =
1134 var_intracellular_ion_concentrations__beta_JSR *
1135 (var_intracellular_ion_concentrations__J_tr -
1136 var_intracellular_ion_concentrations__J_rel); // 'millimole per
1137 // litre per
1138 // second'
1140 var_intracellular_ion_concentrations__d_Ca_NSR_d_environment__time =
1141 ((var_intracellular_ion_concentrations__J_up *
1142 var_intracellular_ion_concentrations__V_myo) /
1143 var_intracellular_ion_concentrations__V_NSR) -
1144 ((var_intracellular_ion_concentrations__J_tr *
1145 var_intracellular_ion_concentrations__V_JSR) /
1146 var_intracellular_ion_concentrations__V_NSR); // 'millimole per
1147 // litre per
1148 // second'
1150 var_chaste_interface__sodium_current_m_gate__d_m_d_environment__time_converter =
1151 var_sodium_current__sodium_current_m_gate__d_m_d_environment__time; // per_second
1153 var_chaste_interface__sodium_current_m_gate__d_m_d_environment__time =
1154 0.001 *
1155 var_chaste_interface__sodium_current_m_gate__d_m_d_environment__time_converter; // 'per millisecond'
1157 var_chaste_interface__sodium_current_h_gate__d_h_d_environment__time_converter =
1158 var_sodium_current__sodium_current_h_gate__d_h_d_environment__time; // per_second
1160 var_chaste_interface__sodium_current_h_gate__d_h_d_environment__time =
1161 0.001 *
1162 var_chaste_interface__sodium_current_h_gate__d_h_d_environment__time_converter; // 'per millisecond'
1164 var_chaste_interface__sodium_current_j_gate__d_j_d_environment__time_converter =
1165 var_sodium_current__sodium_current_j_gate__d_j_d_environment__time; // per_second
1167 var_chaste_interface__sodium_current_j_gate__d_j_d_environment__time =
1168 0.001 *
1169 var_chaste_interface__sodium_current_j_gate__d_j_d_environment__time_converter; // 'per millisecond'
1171 var_chaste_interface__L_type_Ca_channel_d_gate__d_d_d_environment__time_converter =
1172 var_L_type_Ca_channel__L_type_Ca_channel_d_gate__d_d_d_environment__time; // per_second
1174 var_chaste_interface__L_type_Ca_channel_d_gate__d_d_d_environment__time =
1175 0.001 *
1176 var_chaste_interface__L_type_Ca_channel_d_gate__d_d_d_environment__time_converter; // 'per millisecond'
1178 var_chaste_interface__L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time_converter =
1179 var_L_type_Ca_channel__L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time; // per_second
1181 var_chaste_interface__L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time =
1182 0.001 *
1183 var_chaste_interface__L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time_converter; // 'per millisecond'
1185 var_chaste_interface__L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time_converter =
1186 var_L_type_Ca_channel__L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time; // per_second
1188 var_chaste_interface__L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time =
1189 0.001 *
1190 var_chaste_interface__L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time_converter; // 'per millisecond'
1192 var_chaste_interface__L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time_converter =
1193 var_L_type_Ca_channel__L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time; // per_second
1195 var_chaste_interface__L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time =
1196 0.001 *
1197 var_chaste_interface__L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time_converter; // 'per millisecond'
1199 var_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time_converter =
1200 var_Ca_independent_transient_outward_K_current__Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time; // per_second
1202 var_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time =
1203 0.001 *
1204 var_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time_converter; // 'per millisecond'
1206 var_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time_converter =
1207 var_Ca_independent_transient_outward_K_current__Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time; // per_second
1209 var_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time =
1210 0.001 *
1211 var_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time_converter; // 'per millisecond'
1213 var_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time_converter =
1214 var_Ca_independent_transient_outward_K_current__Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time; // per_second
1216 var_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time =
1217 0.001 *
1218 var_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time_converter; // 'per millisecond'
1220 var_chaste_interface__steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time_converter =
1221 var_steady_state_outward_K_current__steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time; // per_second
1223 var_chaste_interface__steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time =
1224 0.001 *
1225 var_chaste_interface__steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time_converter; // 'per millisecond'
1227 var_chaste_interface__steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time_converter =
1228 var_steady_state_outward_K_current__steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time; // per_second
1230 var_chaste_interface__steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time =
1231 0.001 *
1232 var_chaste_interface__steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time_converter; // 'per millisecond'
1234 var_chaste_interface__hyperpolarisation_activated_current_y_gate__d_y_d_environment__time_converter =
1235 var_hyperpolarisation_activated_current__hyperpolarisation_activated_current_y_gate__d_y_d_environment__time; // per_second
1237 var_chaste_interface__hyperpolarisation_activated_current_y_gate__d_y_d_environment__time =
1238 0.001 *
1239 var_chaste_interface__hyperpolarisation_activated_current_y_gate__d_y_d_environment__time_converter; // 'per millisecond'
1241 var_chaste_interface__SR_Ca_release_channel__d_P_O1_d_environment__time_converter =
1242 var_SR_Ca_release_channel__d_P_O1_d_environment__time; // per_second
1244 var_chaste_interface__SR_Ca_release_channel__d_P_O1_d_environment__time =
1245 0.001 *
1246 var_chaste_interface__SR_Ca_release_channel__d_P_O1_d_environment__time_converter; // 'per millisecond'
1248 var_chaste_interface__SR_Ca_release_channel__d_P_O2_d_environment__time_converter =
1249 var_SR_Ca_release_channel__d_P_O2_d_environment__time; // per_second
1251 var_chaste_interface__SR_Ca_release_channel__d_P_O2_d_environment__time =
1252 0.001 *
1253 var_chaste_interface__SR_Ca_release_channel__d_P_O2_d_environment__time_converter; // 'per millisecond'
1255 var_chaste_interface__SR_Ca_release_channel__d_P_C1_d_environment__time_converter =
1256 var_SR_Ca_release_channel__d_P_C1_d_environment__time; // per_second
1258 var_chaste_interface__SR_Ca_release_channel__d_P_C1_d_environment__time =
1259 0.001 *
1260 var_chaste_interface__SR_Ca_release_channel__d_P_C1_d_environment__time_converter; // 'per millisecond'
1262 var_chaste_interface__SR_Ca_release_channel__d_P_C2_d_environment__time_converter =
1263 var_SR_Ca_release_channel__d_P_C2_d_environment__time; // per_second
1265 var_chaste_interface__SR_Ca_release_channel__d_P_C2_d_environment__time =
1266 0.001 *
1267 var_chaste_interface__SR_Ca_release_channel__d_P_C2_d_environment__time_converter; // 'per millisecond'
1269 var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_HTRPNCa_d_environment__time_converter =
1270 var_intracellular_and_SR_Ca_fluxes__d_HTRPNCa_d_environment__time; // ___units_26
1272 var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_HTRPNCa_d_environment__time =
1273 0.001 *
1274 var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_HTRPNCa_d_environment__time_converter; // 'millimolar per millisecond'
1276 var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_LTRPNCa_d_environment__time_converter =
1277 var_intracellular_and_SR_Ca_fluxes__d_LTRPNCa_d_environment__time; // millimole_per_litre_per_second
1279 var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_LTRPNCa_d_environment__time =
1280 0.001 *
1281 var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_LTRPNCa_d_environment__time_converter; // 'millimolar per millisecond'
1283 var_chaste_interface__intracellular_ion_concentrations__d_Na_i_d_environment__time_converter =
1284 var_intracellular_ion_concentrations__d_Na_i_d_environment__time; // millimole_per_litre_per_second
1286 var_chaste_interface__intracellular_ion_concentrations__d_Na_i_d_environment__time =
1287 0.001 *
1288 var_chaste_interface__intracellular_ion_concentrations__d_Na_i_d_environment__time_converter; // 'millimolar per millisecond'
1290 var_chaste_interface__intracellular_ion_concentrations__d_Ca_i_d_environment__time_converter =
1291 var_intracellular_ion_concentrations__d_Ca_i_d_environment__time; // millimole_per_litre_per_second
1293 var_chaste_interface__intracellular_ion_concentrations__d_Ca_i_d_environment__time =
1294 0.001 *
1295 var_chaste_interface__intracellular_ion_concentrations__d_Ca_i_d_environment__time_converter; // 'millimolar per millisecond'
1297 var_chaste_interface__intracellular_ion_concentrations__d_K_i_d_environment__time_converter =
1298 var_intracellular_ion_concentrations__d_K_i_d_environment__time; // millimole_per_litre_per_second
1300 var_chaste_interface__intracellular_ion_concentrations__d_K_i_d_environment__time =
1301 0.001 *
1302 var_chaste_interface__intracellular_ion_concentrations__d_K_i_d_environment__time_converter; // 'millimolar per millisecond'
1304 var_chaste_interface__intracellular_ion_concentrations__d_Ca_ss_d_environment__time_converter =
1305 var_intracellular_ion_concentrations__d_Ca_ss_d_environment__time; // millimole_per_litre_per_second
1307 var_chaste_interface__intracellular_ion_concentrations__d_Ca_ss_d_environment__time =
1308 0.001 *
1309 var_chaste_interface__intracellular_ion_concentrations__d_Ca_ss_d_environment__time_converter; // 'millimolar per millisecond'
1311 var_chaste_interface__intracellular_ion_concentrations__d_Ca_JSR_d_environment__time_converter =
1312 var_intracellular_ion_concentrations__d_Ca_JSR_d_environment__time; // millimole_per_litre_per_second
1314 var_chaste_interface__intracellular_ion_concentrations__d_Ca_JSR_d_environment__time =
1315 0.001 *
1316 var_chaste_interface__intracellular_ion_concentrations__d_Ca_JSR_d_environment__time_converter; // 'millimolar per millisecond'
1318 var_chaste_interface__intracellular_ion_concentrations__d_Ca_NSR_d_environment__time_converter =
1319 var_intracellular_ion_concentrations__d_Ca_NSR_d_environment__time; // millimole_per_litre_per_second
1321 var_chaste_interface__intracellular_ion_concentrations__d_Ca_NSR_d_environment__time =
1322 0.001 *
1323 var_chaste_interface__intracellular_ion_concentrations__d_Ca_NSR_d_environment__time_converter; // 'millimolar per millisecond'
1325 var_chaste_interface__sodium_current_m_gate__d_m_d_environment__time; // 'per millisecond'
1327 var_chaste_interface__sodium_current_h_gate__d_h_d_environment__time; // 'per millisecond'
1329 var_chaste_interface__sodium_current_j_gate__d_j_d_environment__time; // 'per millisecond'
1331 var_chaste_interface__L_type_Ca_channel_d_gate__d_d_d_environment__time; // 'per millisecond'
1333 var_chaste_interface__L_type_Ca_channel_f_11_gate__d_f_11_d_environment__time; // 'per millisecond'
1335 var_chaste_interface__L_type_Ca_channel_f_12_gate__d_f_12_d_environment__time; // 'per millisecond'
1337 d_dt_chaste_interface__L_type_Ca_channel_Ca_inact_gate__Ca_inact =
1338 var_chaste_interface__L_type_Ca_channel_Ca_inact_gate__d_Ca_inact_d_environment__time; // 'per millisecond'
1340 d_dt_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__r =
1341 var_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__d_r_d_environment__time; // 'per millisecond'
1343 d_dt_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__s =
1344 var_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__d_s_d_environment__time; // 'per millisecond'
1346 d_dt_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__s_slow =
1347 var_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__d_s_slow_d_environment__time; // 'per millisecond'
1349 d_dt_chaste_interface__steady_state_outward_K_current_r_ss_gate__r_ss =
1350 var_chaste_interface__steady_state_outward_K_current_r_ss_gate__d_r_ss_d_environment__time; // 'per millisecond'
1352 d_dt_chaste_interface__steady_state_outward_K_current_s_ss_gate__s_ss =
1353 var_chaste_interface__steady_state_outward_K_current_s_ss_gate__d_s_ss_d_environment__time; // 'per millisecond'
1355 d_dt_chaste_interface__hyperpolarisation_activated_current_y_gate__y =
1356 var_chaste_interface__hyperpolarisation_activated_current_y_gate__d_y_d_environment__time; // 'per millisecond'
1358 var_chaste_interface__SR_Ca_release_channel__d_P_O1_d_environment__time; // 'per millisecond'
1360 var_chaste_interface__SR_Ca_release_channel__d_P_O2_d_environment__time; // 'per millisecond'
1362 var_chaste_interface__SR_Ca_release_channel__d_P_C1_d_environment__time; // 'per millisecond'
1364 var_chaste_interface__SR_Ca_release_channel__d_P_C2_d_environment__time; // 'per millisecond'
1366 d_dt_chaste_interface__intracellular_and_SR_Ca_fluxes__HTRPNCa =
1367 var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_HTRPNCa_d_environment__time; // 'millimole per litre per millisecond'
1369 d_dt_chaste_interface__intracellular_and_SR_Ca_fluxes__LTRPNCa =
1370 var_chaste_interface__intracellular_and_SR_Ca_fluxes__d_LTRPNCa_d_environment__time; // 'millimole per litre per millisecond'
1372 var_chaste_interface__intracellular_ion_concentrations__d_Na_i_d_environment__time; // 'millimole per litre per millisecond'
1374 var_chaste_interface__intracellular_ion_concentrations__d_Ca_i_d_environment__time; // 'millimole per litre per millisecond'
1376 var_chaste_interface__intracellular_ion_concentrations__d_K_i_d_environment__time; // 'millimole per litre per millisecond'
1378 d_dt_chaste_interface__intracellular_ion_concentrations__Ca_ss =
1379 var_chaste_interface__intracellular_ion_concentrations__d_Ca_ss_d_environment__time; // 'millimole per litre per millisecond'
1381 d_dt_chaste_interface__intracellular_ion_concentrations__Ca_JSR =
1382 var_chaste_interface__intracellular_ion_concentrations__d_Ca_JSR_d_environment__time; // 'millimole per litre per millisecond'
1384 d_dt_chaste_interface__intracellular_ion_concentrations__Ca_NSR =
1385 var_chaste_interface__intracellular_ion_concentrations__d_Ca_NSR_d_environment__time; // 'millimole per litre per millisecond'
1386
1390 var_L_type_Ca_channel__i_Ca_L; // nanoA
1392 var_Ca_independent_transient_outward_K_current__i_t; // nanoA
1394 var_steady_state_outward_K_current__i_ss; // nanoA
1396 var_hyperpolarisation_activated_current__i_f_Na +
1397 var_hyperpolarisation_activated_current__i_f_K; // nanoA
1399 var_hyperpolarisation_activated_current__i_f; // nanoA
1401 var_inward_rectifier__i_K1; // nanoA
1403 var_background_currents__i_B_Na + var_background_currents__i_B_Ca +
1404 var_background_currents__i_B_K; // nanoA
1406 var_background_currents__i_B; // nanoA
1408 var_sodium_potassium_pump__i_NaK; // nanoA
1410 var_Na_Ca_ion_exchanger_current__i_NaCa; // nanoA
1412 var_sarcolemmal_calcium_pump_current__i_Ca_P; // nanoA
1415 var_chaste_interface__membrane__i_Stim; // uA_per_cm2
1417 var_membrane__chaste_interface__chaste_membrane_capacitance =
1418 1.0; // uF_per_cm2
1420 1000.0 *
1421 ((var_membrane__i_Stim_converter * var_membrane__Cm) /
1422 var_membrane__chaste_interface__chaste_membrane_capacitance); // nanoA
1424 (-(var_membrane__i_Na + var_membrane__i_Ca_L + var_membrane__i_t +
1425 var_membrane__i_ss + var_membrane__i_f + var_membrane__i_K1 +
1426 var_membrane__i_B + var_membrane__i_NaK + var_membrane__i_NaCa +
1427 var_membrane__i_Ca_P + var_membrane__i_Stim)) /
1428 var_membrane__Cm; // 'millivolt per second'
1430 var_chaste_interface__membrane__d_V_d_environment__time_converter =
1431 var_membrane__d_V_d_environment__time; // ___units_1
1433 0.001 *
1434 var_chaste_interface__membrane__d_V_d_environment__time_converter; // 'millivolt per millisecond'
1435 d_dt_chaste_interface__membrane__V =
1436 var_chaste_interface__membrane__d_V_d_environment__time; // 'millivolt
1437 // per
1438 // millisecond'
1439 outarray[0][i] = d_dt_chaste_interface__membrane__V;
1440 outarray[1][i] = 0.0;
1441 outarray[2][i] = d_dt_chaste_interface__sodium_current_m_gate__m;
1442 outarray[3][i] = d_dt_chaste_interface__sodium_current_h_gate__h;
1443 outarray[4][i] = d_dt_chaste_interface__sodium_current_j_gate__j;
1444 outarray[5][i] = d_dt_chaste_interface__L_type_Ca_channel_d_gate__d;
1445 outarray[6][i] =
1446 d_dt_chaste_interface__L_type_Ca_channel_f_11_gate__f_11;
1447 outarray[7][i] =
1448 d_dt_chaste_interface__L_type_Ca_channel_f_12_gate__f_12;
1449 outarray[8][i] =
1450 d_dt_chaste_interface__L_type_Ca_channel_Ca_inact_gate__Ca_inact;
1451 outarray[9][i] =
1452 d_dt_chaste_interface__Ca_independent_transient_outward_K_current_r_gate__r;
1453 outarray[10][i] =
1454 d_dt_chaste_interface__Ca_independent_transient_outward_K_current_s_gate__s;
1455 outarray[11][i] =
1456 d_dt_chaste_interface__Ca_independent_transient_outward_K_current_s_slow_gate__s_slow;
1457 outarray[12][i] =
1458 d_dt_chaste_interface__steady_state_outward_K_current_r_ss_gate__r_ss;
1459 outarray[13][i] =
1460 d_dt_chaste_interface__steady_state_outward_K_current_s_ss_gate__s_ss;
1461 outarray[14][i] =
1462 d_dt_chaste_interface__hyperpolarisation_activated_current_y_gate__y;
1463 outarray[15][i] = d_dt_chaste_interface__SR_Ca_release_channel__P_O1;
1464 outarray[16][i] = d_dt_chaste_interface__SR_Ca_release_channel__P_O2;
1465 outarray[17][i] = d_dt_chaste_interface__SR_Ca_release_channel__P_C1;
1466 outarray[18][i] = d_dt_chaste_interface__SR_Ca_release_channel__P_C2;
1467 outarray[19][i] =
1468 d_dt_chaste_interface__intracellular_and_SR_Ca_fluxes__HTRPNCa;
1469 outarray[20][i] =
1470 d_dt_chaste_interface__intracellular_and_SR_Ca_fluxes__LTRPNCa;
1471 outarray[21][i] =
1472 d_dt_chaste_interface__intracellular_ion_concentrations__Na_i;
1473 outarray[22][i] =
1474 d_dt_chaste_interface__intracellular_ion_concentrations__Ca_i;
1475 outarray[23][i] =
1476 d_dt_chaste_interface__intracellular_ion_concentrations__K_i;
1477 outarray[24][i] =
1478 d_dt_chaste_interface__intracellular_ion_concentrations__Ca_ss;
1479 outarray[25][i] =
1480 d_dt_chaste_interface__intracellular_ion_concentrations__Ca_JSR;
1481 outarray[26][i] =
1482 d_dt_chaste_interface__intracellular_ion_concentrations__Ca_NSR;
1483 }
1484}
References tinysimd::log(), and Nektar::CellModel::m_nq.
Member Data Documentation
◆ className
|
static |
Initial value:
=
"PanditGilesDemir03", PanditGilesDemir03::create,
"Pandit-Giles-Demir 2003 cell model.")
tKey RegisterCreatorFunction(tKey idKey, CreatorFunction classCreator, std::string pDesc="")
Register a class with the factory.
Definition: BasicUtils/NekFactory.hpp:197
static CellModelSharedPtr create(const LibUtilities::SessionReaderSharedPtr &pSession, const MultiRegions::ExpListSharedPtr &pField)
Creates an instance of this class.
Definition: PanditGilesDemir03.h:46
Name of class.
Definition at line 55 of file PanditGilesDemir03.h.
